Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.…”
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Tick species, tick-borne pathogen distribution and risk factor analysis in border areas of China, Russia and North Korea by Pengfei Min, Jianchen Song, Shaowei Zhao, Zhen Ma, Yinbiao Meng, Zeyu Tang, Zhenyu Wang, Sicheng Lin, Fanglin Zhao, Meng Liu, Longsheng Wang, Lijun Jia, Lijun Jia

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Clinical characteristics of pathogens in children with community-acquired pneumonia were analyzed via targeted next-generation sequencing detection by Junhua Zhao, Mingfeng Xu, Zheng Tian, Yu Wang

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Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? by Krishna D. Bharwani, Maaike Dirckx, Dirk L. Stronks, Willem A. Dik, Marco W. J. Schreurs, Frank J. P. M. Huygen

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Lactococcus garvieae: An Uncommon Human Pathogen Causing Infective Endocarditis in a Valve-in-Valve Transcatheter Aortic Valve Replacement by Diego H. González-Bravo, Sergio Alegre-Boschetti, Richard Silva-Cantillo, Joshua Mercado-Maldonado, Reyshley Ramos-Márquez, Gabriel Torres-Rivera, Carlos Cortés, Josue Mercado-Crespo

“…Lactococcus garvieae is a fish pathogen and an uncommon cause of human infections. …”
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A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells. by Ernesto Canalis, Jungeun Yu, Lauren Schilling, Paymaan Jafar-Nejad, Michele Carrer

“…Lateral Meningocele Syndrome (LMS), a disorder associated with NOTCH3 pathogenic variants, presents with neurological, craniofacial and skeletal abnormalities. …”
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RASGRF2 as a potential pathogenic gene mediating the progression of alcoholic hepatitis to alcohol-related cirrhosis and hepatocellular carcinoma by Zhengyuan Chen, Danfeng Fan, Tianyi Hang, Xiaoqing Yue

“…Conclusion RASGRF2 serve as a pathogenic gene that mediates the progression of AH to AC and potentially to HCC.…”
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Expanding the Phenotype of Congenital Glucocorticoid Deficiency: An Iranian Patient with Cholestasis due to Pathogenic Variants in the MC2R Gene by Shohreh Maleknejad, Setila Dalili, Ameneh Sharifi, Afagh Hassanzadeh Rad, Reza Bayat, Bahareh Rabbani, Nejat Mahdieh

“…Two variants in the MC2R gene, c.560delT and c.676G > C, were detected and classified as pathogenic and likely pathogenic, respectively. The cooccurrence of cholestasis and glucocorticoid deficiency illustrates the clinical heterogeneity caused by MC2R variants. …”
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Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands by Catarina Falcão de Campos, Miguel Oliveira Santos, Rafael Roque, Isabel Conceição, Mamede de Carvalho

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Pre-gestational diabetes in a young woman with a pathogenic INSR missense mutation, p.(Met1180Lys) by Emma L Prehn, Mairéad Crowley, David Fennell, Brendan T Kinsley, Kevin Colclough, Maria M Byrne

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The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis by Haomiao Shen, Jinlin Miao, Haoyang Sun, Kui Zhang, Renli Liu, Zichao Li, Leyang Zhang, Peiyan Zhang, Jiawei Wang, Bei Zhang, Longyu Chen, Zhaohui Zheng, Ping Zhu

“…In vitro functional assays were performed to evaluate the pathogenic properties of CD8⁺CD28^null Tang. …”
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A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts by Mustak Ibn Ayub

“…Thus, 28881–28883: GGG > AAC bloc mutation is expected to modulate the pathogenicity of SARS-CoV-2. These analyses suggest that SARS-CoV-2 has evolved into SARS-CoV-2a affecting COVID-19 infectivity and severity. …”
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Biosynthesis of silver nanoparticles from macroalgae Hormophysa triquetra and investigation of its antibacterial activity and mechanism against pathogenic bacteria by Shazia Bibi, Mohammed H. Abu-Dieyeh, Mohammad A. Al-Ghouti

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Significance of Combining Bronchoalveolar Lavage Fluid With Targeted Next‐Generation Sequencing in the Pathogen Detection‐Based Diagnosis of Pulmonary Infections by Jiangbo Liu, Bo Yang, Yu Wu, Guihong Yang, Xiaojiu Zha, Wei Jiang

“…The comprehensive positive pathogen detection‐based diagnosis rate for tNGS was 86.6%, with a single‐pathogen lung infection diagnosis rate of 85.7% and a mixed‐pathogen pulmonary infection diagnosis rate of 88.0%. …”
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Essential Oils from Thymus capitatus and Thymus algeriensis as Antimicrobial Agents to Control Pathogenic and Spoilage Bacteria in Ground Meat by Asma Jayari, Ahlem Jouini, Hager Boukhris, Safa Hamrouni, Chokri Damergi, Sami Ben Hadj Ahmed, Abderrazek Maaroufi

“…The results illustrated the efficacy of both EOs as preservatives in food against well-known pathogens of food-borne diseases and food spoilage, particularly in P. aeruginosa in beef meat. …”
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Spatial analysis of milk and cottage cheese reveals poor microbial quality and contamination with foodborne pathogens in the central highlands of Ethiopia by Abdi Keba, Gebrerufael Girmay, Henok Nahusenay, Ashagrie Zewdu

“…The objective of this study was to evaluate microbial quality and safety of milk and cottage cheese and spatial distribution of microbial quality indicators and foodborne pathogens along the dairy value chain in the three regions of the country.MethodsA cross-sectional study was conducted from December 2020 to May 2021. …”
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Analysis of respiratory pathogen detection in hospitalized children with acute respiratory tract infections after ending the zero COVID policy by Xuena Xu, Yizhu Zhang, Lina Xu, Wujun Jiang, Chuangli Hao

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Genomic typing, antimicrobial resistance gene, virulence factor and plasmid replicon database for the important pathogenic bacteria Klebsiella pneumoniae by Andrey Shelenkov, Anna Slavokhotova, Yulia Mikhaylova, Vasiliy Akimkin

“…It will be helpful for investigations in the field of K. pneumoniae genomic epidemiology, as well as antimicrobial resistance analysis and the development of prevention measures against this important pathogen.…”
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Evaluating the in vitro activity of cefoperazone-sulbactam against Gram negative pathogens in blood stream infections using automated systems by Uksim Qadri, Sofiya Zaffar, Saleem Javaid Wani, Shugufta Roohi, Munazah Aman, Sabah Bhat, Umaya Majid

“…Conclusion: Cefoperazone-sulbactam demonstrates robust activity against the most frequently encountered clinical pathogens, suggesting its potential as an efficacious therapeutic agent. …”
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Antibacterial and antibiofilm activity of peptide PvGBP2 against pathogenic bacteria that contaminate Auricularia auricular culture bags by Shen Yang, Zijin Yuan, Jude Juventus Aweya, Shanggui Deng, Wuyin Weng, Yueling Zhang, Guangming Liu

“…Thus, peptide PvGBP2 could be potentially applied as an antibacterial agent to control bacterial infection of A. auricular cultivation and the spread of foodborne pathogens.…”
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