Genetic divergence of hot pepper lines (Capsicum spp.) in hybrid combinations by Šević Biljana, Cvikić Dejan, Slađana Savić, Tupajić Ivan, Ugirnović Milan, Bajagić Marija, Luković Kristina, Stojiljković Jelena

“…Hybrids offer numerous advantages over varieties, including higher yields, fruit uniformity, resistance to plant pathogens, and the manifestation of heterosis. These are the primary reasons for initiating research on hybrid combinations of hot peppers. …”
Get full text

Microbes on the Mobile Phones of Healthcare Workers in Palestine: Identification, Characterization, and Comparison by Mohammad Qadi, Rasha Khayyat, Mohammed A. AlHajhamad, Yazan I. Naji, Beesan Maraqa, Kais Abuzaitoun, Ahmed Mousa, Maysa Daqqa

“…Therefore, infection control teams should discuss methods to prevent the transmission of drug-resistant pathogens from HCW MPs.…”
Get full text

Identification and functional analysis of a novel SMARCC2 splicing variant in a family with syndromic neurodevelopmental disorder by Ming Li, Jingqi Lin, Hongjun Fei, Jinyu Liu, Yiyao Chen, Xu Han, Yanlin Wang, Jian Wang, Renyi Hua, Shuyuan Li, Niu Li

“…Abstract Background To determine the pathogenicity of a novel splicing variant in the SMARCC2 gene identified from a pair of adult male monozygotic twins with neurodevelopmental disorder, and to investigate the genotype-phenotype characteristics associated with SMARCC2 variants. …”
Get full text

Characterization and fungicides sensitivity of Colletotrichum species causing Hydrangea macrophylla anthracnose in Beijing, China by Juan Zhao, Juan Zhao, Yanli Cheng, Yanli Cheng, Yayong Liu, Yayong Liu, Xiaojing Shi, Taotao Zhang, Taotao Zhang, Wentao Qin, Wentao Qin

“…Among which, C. gloeosporioides was the most abundant (65 isolates, 57.0%), followed by C. fructicola (33 isolates, 28.9%), C. aenigma (8 isolates, 7.0%), C. truncatum (4 isolates, 3.5%), C. subacidae (2 isolates, 1.8%) and C. sojae (2 isolates, 1.8%). Pathogenicity test conducted on detached leaves of H. macrophylla revealed a distinct variation in virulence among isolates from different Colletotrichum species, and wounding was either essential or conducive to successful infection. …”
Get full text

Functional and Structural Consequences of Nine CYP21A2 Mutations Ranging from Very Mild to Severe Effects by Débora de Paula Michelatto, Leif Karlsson, Ana Letícia Gori Lusa, Camila D’Almeida Mgnani Silva, Linus Joakim Östberg, Bengt Persson, Gil Guerra-Júnior, Sofia Helena Valente de Lemos-Marini, Michela Barbaro, Maricilda Palandi de Mello, Svetlana Lajic

“…Functional analyses were complemented with in silico prediction of mutation pathogenicity based on the recently crystallized human CYP21A2 structure. …”
Get full text

Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…This article first summarizes classic modeling methods for sepsis related organ injury, including the destruction of intestinal barrier tissue integrity and the implantation of pathogens or toxic drugs. The former mainly includes cecal ligation and puncture, ascending colon stent implantation, and cecal ligation incision. …”
Get full text

High prevalence of multidrug resistant and extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in the West reg... by Solomon Bayaba, Raspail Carrel Founou, Flaurant Thibau Tchouangueu, Brice Davy Dimani, Lethicia Danaëlle Mafo, Omer Aurelle Nkengkana, Luria Leslie Founou, Michel Noubom

“…Multidrug resistant and Extended-Spectrum β-Lactamase producing-Enterobacterales (ESBL-E) are pathogens of critical public health priority that urgently require the research and development of new drugs. …”
Get full text

Russian Science Foundation grant No. 20-14-00140 supported this study. The authors are thankful to the multi-access Center “Bioinformatics” for the use of computational resources a... by O. V. Vishnevsky, I. V. Chadaeva, E. B. Sharypova, B. M. Khandaev, K. A. Zolotareva, A. V. Kazachek, P. M. Ponomarenko, N. L. Podkolodny, D. A. Rasskazov, E. V. Zemlyanskaya, A. G. Bogomolov, O. A. Podkolodnaya, L. K. Savinkova, M. P. Ponomarenko

“…It is generally accepted that during the domestication of food plants, selection was focused on their productivity, the ease of their technological processing into food, and resistance to pathogens and environmental stressors. Besides, the palatability of plant foods and their health benefits could also be subjected to selection by humans in the past. …”
Get full text

The Epidemiological Characteristics of Coronavirus Disease (COVID-19) in Halabja Province/Kurdistan –Iraq by Osama Hamid Shareef, Othman Abdulrahman Mohammed, Dashty Aziz Ghafor, Ari Shareef Ali, Hardi Rafat Baqi, Ali Aziz Ali, Aryan Mahmood Faraj, Syamand Ahmed Qadir, Ali Muhi Aldeen Omar Aljabary

“…The new highly transmitted pathogenic viral infection started from Wuhan, China at the end of 2019. …”
Get full text

Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…In addition, our data point to the pathogenic potential of the conversion of conventional adaptive B cells, which are the most common population of mature B cells, into innate-like B cells and the production of autoreactive IgA antibodies during homeostatic proliferation. …”
Get full text

Effect of diet containing alfalfa (Medicago sativa) powder and leaf extract on hemolymph factors of western whiteleg shrimp (Litopenaeus vannamei) under low salinity stress by Kobra Babanejad Abkenar, Arash Akbarzadeh, Ahmad Noori, Mohammad Niroomand

“…Hemocytes are crucial in crustaceans' defense against pathogens. A higher proportion of semi-granular cells in the western whiteleg shrimp indicate a stronger immune response. …”
Get full text

The diagnostic accuracy of point-of-care nucleic acid-based isothermal amplification assays for scrub typhus: a systematic review and meta-analysis by Rashi Dixit, Sandeep Manikandan, John Antony Jude Prakash, Manisha Biswal, Dharitri Mohapatra, Natarajan Gopalan, G. Gnanamani, Sujit Kumar Behera

“…IntroductionThe diagnosis and detection of pathogens such as Rickettsia and Orientia is a cause of major concern among the public health community. …”
Get full text

Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…This process enhances the clearance of pathogenic microorganisms during the acute phase of colitis, while inducing sustained inflammatory responses during the remission phase.Conclusion: In summary, our study demonstrates the dual role of HPA activation and α-MSH secretion induced by colitis in the pathogenesis of IBD. …”
Get full text

Effects of Dietary Tea Polyphenols on the Growth, Antioxidant Status, Immune Function, and Intestinal Microbiota of Largemouth Bass (<i>Micropterus salmoides</i>) by Zixin Yang, Qiuwen Su, Jiafa Yang, Zhijun Li, Shanren Lan, Xu Jia, Paihuai Ouyang, Huijuan Tang

“…With the increase in dietary TPs, distinct differences were observed in the intestinal microbial composition and the relative abundance of potential pathogens, especially <i>Clostridiaceae</i>, which decreased, along with the enrichment of pathways related to metabolism, including amino acid metabolism, carbohydrate metabolism, and lipid metabolism. …”
Get full text

Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty by Ting Chen, Linqi Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Fei Xiao

“…According to ACMG standards, two MKRN3 variant (p.Glu380Lys and p.Ile357Met) are likely pathogenic, and two others are of uncertain significance. …”
Get full text

Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…The principal pathways enriched were involved in cell cycle progression Toxoplasmosis, Cell adhesion molecules, Influenza A, Pathogenic Escherichia coli infection, Small cell lung cancer, Amoebiasis, TNF signaling pathway, and Leukocyte transendothelial migration. …”
Get full text

Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…However, we encountered challenges that complicated pleural infection interpretation, including: (i) uncertainties regarding microbial pathogenicity and the impact of prior antibiotic therapy on diagnostic performance; (ii) lack of a clinical diagnostic gold-standard for molecular performance comparisons; (iii) potential microbial contamination during specimen collection or processing; and (iv) difficulties distinguishing background microbial noise from true microbial signal in low-biomass specimens. …”
Get full text

Mechanism of Mongolian Medicine Batri-7 on Salmonella Enteritis by Yang D, Chen S, Borijihan H, Aoqier A, Sarula S, Siqin S, Manda M, Temuqile T, Baigude H

“…Through this study, we discovered the mechanism of BT-7’s dual action on the host and pathogenic bacteria. This gives inspiration for anti-infective disease research in traditional medicine and also proves that traditional medicines still have good prospects for treating infectious diseases.Keywords: Mongolian medicine, Batri-7, antibacterial, Salmonella enteritis, virulence gene…”
Get full text

Glaucoma progression during the COVID-19 pandemics by V.E. Korelina, I.R. Gazizova, A.V. Kuroyedov, M.D. Didur

“…Mandryka Military Clinical Hospital, Moscow, Russian Federation</b> </p> <p> <b>⁴Pirogov Russian National Research Medical University, Moscow, Russian Federation</b> </p> <p> <i>The novel coronavirus infection (COVID-19) provides powerful effects on all pathogenic aspects of the primary open-angle glaucoma (POAG). …”
Get full text

Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…<b>Background/Objectives</b>: Macrophages play a pivotal role in various pathogenic processes, necessitating the development of efficient differentiation techniques to meet the high demand for these cells in research and therapy. …”
Get full text