In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…The quick development of novel therapeutic compounds is required in the fight against such pathogenic agents. Unfortunately, the traditional drug development methods are time-consuming and expensive. …”
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Voriconazole Pharmacokinetics Administered at 4 mg/kg IM and IV in Nursehound Sharks (<i>Scyliorhinus stellaris</i>) Under Human Care by Daniela Cañizares-Cooz, Daniel García-Párraga, Sonia Rubio-Langre, Teresa Encinas, Pablo Morón-Elorza

“…Moreover, further research on the susceptibility of fungal pathogens affecting elasmobranchs is needed to establish an optimal dosing regimen for IM voriconazole in the treatment of mycosis in sharks.…”
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Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…BackgroundThe marine Gram-negative bacterium Vibrio anguillarum is one of the major pathogens in aquaculture. Iron uptake is a prerequisite for virulence and is strictly controlled by a global iron uptake regulator, Fur, which acts as a repressor under iron-replete conditions. …”
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Candida Bloodstream Infection: Changing Pattern of Occurrence and Antifungal Susceptibility over 10 Years in a Tertiary Care Saudi Hospital by Nawaf Alkharashi, Sameera Aljohani, Laila Layqah, Emad Masuadi, Waleed Baharoon, Hamdan AL-Jahdali, Salim Baharoon

“…Candida has emerged as one of the most important pathogens that cause bloodstream infection (BSI).Understanding the current Candida BSI trends, the dominant species causing disease and the mortality associated with this infection are crucial to optimize therapeutic and prophylaxis measures. …”
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Preliminary evidence of immune infiltration and neutrophil degranulation in peripheral blood of non-obese OSA patients related to cognitive decline by Qingqing Liu, Yanru Ou, Ting Liu, Yuming He, Xiangming Quan, Ruoyun Ouyang, Zhihui Shi

“…Abstract Obstructive sleep apnea (OSA) patients have varying degrees of cognitive impairment, but the specific pathogenic mechanism is still unclear. Meanwhile, poor compliance with continuous positive airway pressure (CPAP) in OSA prompts better solutions. …”
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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…In the mostly annotated variant (ENSP00000241393) of the CXCR4 gene, we found 23 highly deleterious and pathogenic nsSNPs and these were selected for in-depth analysis. …”
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Adult dietary patterns and their association with iodine nutrition levels and thyroid function: a cross-sectional study by Gulinaizeer Abuduwaili, Jia Huang, Yan Ma, Hongguang Sun

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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…This study employs immune infiltration analysis and bioinformatics to unveil the pathogenic mechanisms of EOS and identify potential diagnostic biomarkers, aiming for more precise clinical interventions. …”
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A comprehensive review of probiotics and human health-current prospective and applications by Bhutada Sarita, Dahikar Samadhan, Md Zakir Hassan, Md Zakir Hassan, Elena G. Kovaleva

“…It not only improves the viability and stability of probiotic cells, but also inhibits the growth of pathogenic strains. Lactobacillus and Bifidobacterium spp. are most commonly used as probiotics. …”
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Composition of the collection of wild apple-tree species and its prospects for use in breeding by O. N. Barsukova

“…However, constantly evolving virulence of pathogens poses the need to search for sources of new non-identical genes of disease resistance and use them in breeding practice. …”
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Impact of pulmonary yoga module on lung capacity of COVID-19 adult survivors by Adarsh Tomar, Sudhanshu Verma

“…There is a hypothesis that yoga improves lung capacity significantly, which is a front-line fighter against any pathogens or viruses that intrude inside the body. …”
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Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists by Christian Behm, Alice Blufstein, Johannes Gahn, Nazanin Noroozkhan, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov

“…Changes in the local sCD14 level may be considered as a crucial factor influencing the susceptibility of hPDLSCs to different pathogens and thus may contribute to the progression of periodontitis.…”
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Survival of Salmonella on Biodegradable Mulch, Landscape Fabric, and Plastic Mulch by Alyssa A. Rosenbaum, Claire M. Murphy, Annette L. Wszelaki, Alexis M. Hamilton, Steven L. Rideout, Laura K. Strawn

“…While various factors are considered when selecting commercial ground covers, food safety, particularly the survival of foodborne pathogens, is often overlooked. This study aimed to assess the survival of Salmonella on different ground covers, including biodegradable mulch, landscape fabric, and plastic mulch. …”
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Imprint of ancestral and modern threats in human mind – experience of fear, disgust, and anger by Eva Landová, Eva Landová, Jakub Polák, Jakub Polák, Markéta Janovcová, Iveta Štolhoferová, Šárka Peterková, Aleksandra Chomik, Daniel Frynta

“…Animal and human ancestors developed complex physiological and behavioral response systems to cope with two types of threats: immediate physical harm from predators or conspecifics, triggering fear, and the risk of infections from parasites and pathogens leading to the evolution of the behavioral immune system (BIS) with disgust as the key emotion. …”
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Clinical characteristics and prognosis of children with culture-negative osteoarticular infections: a meta-analysis based on cohort studies by Xingguang Chen, Jue Liu, Mingfeng Xue, Ting Zhuang, Feng Yao, Jialing Lu, Xiaodong Wang

“…The inability to identify pathogens can lead to incorrect antibiotic usage or under-treatment, increasing the risk of adverse outcomes. …”
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Non-Thermal Plasma-Activated Water Enhances Nursery Production of Vegetables: A Species-Specific Study by Silvia Locatelli, Stefano Triolone, Marina De Bonis, Giampaolo Zanin, Carlo Nicoletto

“…This technology has shown potential benefits in boosting seed germination, promoting plant growth, as an effective defense against plant pathogens, and increasing systemic plant resistance. …”
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Synovial fluid leukocytes as diagnostic marker in periprosthetic shoulder infection by Stefan Köppe, Daniel Karczewski, MD, Rony-Orijit Dey Hazra, MD, Alp Paksoy, MD, Agahan Hayta, MD, Doruk Akgün, MD

“…Sonication detected pathogens in 63% of cases, while 57% of all cases showed positive tissue cultures and 43% positive aspirate cultures. …”
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Kidney and liver histopathology of sea bass Lates calcarifer infected with black body syndrome-associated bacteria by Sri Nuryati, Mauliza Yanti, Rahman, Sutiastuti Wahyuwardani

“…Microscopic anatomical pathology of each bacterium needs to be done to determine its pathogenicity. This study aims to compare the degree of damage to sea bass juveniles' liver and kidney organs through histopathological observations due to bacterial infections that cause BBS. …”
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Source attribution of human Campylobacter infection: a multi-country model in the European Union by Cecilie Thystrup, Maja Lykke Brinch, Clementine Henri, Lapo Mughini-Gras, Lapo Mughini-Gras, Eelco Franz, Kinga Wieczorek, Montserrat Gutierrez, Deirdre M. Prendergast, Geraldine Duffy, Catherine M. Burgess, Declan Bolton, Julio Alvarez, Julio Alvarez, Vicente Lopez-Chavarrias, Thomas Rosendal, Lurdes Clemente, Ana Amaro, Aldert L. Zomer, Katrine Grimstrup Joensen, Eva Møller Nielsen, Gaia Scavia, Magdalena Skarżyńska, Miguel Pinto, Mónica Oleastro, Wonhee Cha, Amandine Thépault, Katell Rivoal, Martine Denis, Marianne Chemaly, Tine Hald

“…National action plans have included source attribution studies as a way to quantify the contribution of specific sources and understand the dynamic of transmission of foodborne pathogens like Salmonella and Campylobacter. Such information is crucial for implementing targeted intervention. …”
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