Protocol for a Phase 2 randomized controlled patient-assessor blinded study: efficacy and safety of combined cortical and cerebellar dual-target transcranial magnetic stimulation f... by Jing Xu, Na Cao, Yan Qu, Suhang Shang, Xincheng Liu, Xuexin Wang, Fangfang Hu, Xuerong Bai, Qiumin Qu, Meng Zhang, Hongmei Cao

“…Abnormal cerebello-thalamo-cortical (CTC) loop function are thought to be significant pathogenic causes of ET, with the cerebellum and cortex are common targets for ET treatment. …”
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Transcriptome-wide dynamics of m6A methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV by Qijin Miao, Jing Jiang, Siyou Huang, Jie Gao, Qingqing Liu, Rui Zheng, Yiling Kang, Changjun Guo, Jianguo He, Junfeng Xie

“…However, the impact of m6A RNA methylation on the pathogenicity of ISKNV remains unexplored. Here, methylated RNA immunoprecipitation sequencing (MeRIP-seq) coupled with RNA sequencing (RNA-seq) was used to systematically detect variations in m6A methylation and gene expression between ISKNV-infected and noninfected MFF-1 cells, followed by functional enrichment and co-expression joint analysis. …”
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Updates on the molecular spectrum of MEFV variants in lebanese patients with Familial Mediterranean Fever by Rudy Feghali, José-Noel Ibrahim, Nabiha Salem, Romy Moussallem, Ghina Hijazi, Charbel Attieh, Tony Yammine, Alain Chebly, Alain Chebly

“…Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disorder, particularly present in the Mediterranean populations, and associated with pathogenic variants in the MEFV gene. This study aims to investigate the distribution of MEFV variants in a large cohort of Lebanese patients, and to explore the genotype-phenotype correlation among affected individuals. …”
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Effects of аntimicrobials on <i>Pseudomonas aeruginosa</i> biofilm formation by U. M. Nemchenko, K. O. Sitnikova, N. L. Belkova, E. V. Grigorova, N. M. Voropaeva, M. V. Sukhоreva, E. S. Sukhareva, E. D. Savilov

“…Pseudomonas aeruginosa is one of the most problematic pathogens in medical institutions, which may be due to the ability of this microorganism to exist in a biofilm, which increases its resistance to antimicrobials, as well as its prevalence and survival ability in the external environment. …”
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Comparative Analysis of <i>In Vivo</i> and <i>In Vitro</i> Virulence Among Foodborne and Clinical <i>Listeria monocytogenes</i> Strains by Hui Yan, Biyao Xu, Binru Gao, Yunyan Xu, Xuejuan Xia, Yue Ma, Xiaojie Qin, Qingli Dong, Takashi Hirata, Zhuosi Li

“…<i>Listeria monocytogenes</i> is one of the most important foodborne pathogens that can cause invasive listeriosis. In this study, the virulence levels of 26 strains of <i>L. monocytogenes</i> isolated from food and clinical samples in Shanghai, China, between 2020 and 2022 were analyzed. …”
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Annotated Checklist of Poroid Hymenochaetoid Fungi in Central Asia: Taxonomic Diversity, Ecological Roles, and Potential Distribution Patterns by Yusufjon Gafforov, Manzura Yarasheva, Xue-Wei Wang, Milena Rašeta, Yelena Rakhimova, Lyazzat Kyzmetova, Kanaim Bavlankulova, Sylvie Rapior, Jia-Jia Chen, Ewald Langer, Burkhon Munnavarov, Zafar Aslonov, Bobozoda Bakokhoja, Li-Wei Zhou

“…These macrofungi play essential ecological roles as saprotrophs and pathogens of various identified host plant families, aiding in lignin degradation and exhibiting diverse enzymatic activities. …”
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Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus by Kanana Rungprasert, Wikanda Tunterek, Phornphisut Areeraksakul, Duangduean Prakairungnamthip, Chalida Sri-in, Navapon Techakriengkrai, Wijit Banlunara, Christine A. Jansen, Teerawut Nedumpun, Aunyaratana Thontiravong

“…Duck Tembusu virus (DTMUV), an emerging avian pathogenic flavivirus, causes severe neurological disorders and acute egg drop syndrome in ducks. …”
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Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons by Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Yu-Xin Chen, Long-Ji Sun, Shi-Hao Li, Wen-Rui Wang, Fan Yang

“…Based on the AUC/MIC ratios calculated here, the current IM or IV administration at 10 mg/kg BW is effective against bacterial infections with MIC values ≤ 0.1 μg/mL, while the current oral dose (10 mg/kg BW) may be insufficient, particularly for infections caused by pathogens with MIC values exceeding 0.1 μg/mL.…”
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Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…These results confirm that the plant core microbiome includes pathogenic and not only commensal or mutualistic taxa. …”
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Lidocaine Shows Significant Antimicrobial Effects Against <i>Staphylococcus</i> Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injecta... by Stephan Heller, Ricarda Johanna Seemann, Rainer Burgkart, Andreas Obermeier, Hermann Locher

“…Conclusions: Lidocaine exhibits dose-dependent antimicrobial effects against key pathogens responsible for septic arthritis. Its combination with Triam40 and hyaluronan may reduce the risk of septic arthritis, supporting its clinical relevance.…”
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Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity by Suleiman Al-Hammadi, Najla S. Alkuwaiti, Ghassan A. Ghatasheh, Huda Al Dhanhani, Hiba M. Shendi, Abdulghani S. Elomami, Farida Almarzooqi, Abdul-Kader Souid

“…This young infant was diagnosed at six months of age with “immunodeficiency type 19” (MIM#615617) due to homozygous nonsense variant, NM_000732.4 (CD3D):c.128G > A, p.Trp43∗ (variation ClinVar#VCV000643120.1; pathogenic). This variant creates premature stop-gain in CD3D (CD3 antigen, delta subunit, autosomal recessive; MIM#186790), resulting in loss-of-function. …”
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Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital by Paulami De, Rehena Sarkar, Raja Ray, Kumkum Bhattacharyya, Hasina Banu, Hirak Jyoti Raj

“…Maximum number of isolates came from central line catheter 43, followed by blood 19. other samples from where candida were isolated are urine 13, endotracheal aspirate 9, Pleural fluid 7, Bronchoalveolar lavage 3, Cerebrospinal Fluid 3 and Wound 3. Isolated pathogens were Candida albicans. Candida tropicalis, Candida parapsilosis, Candida glabrata, Candida auris, Candida guilliermondii , Candida haemulonii, Candida ciferrii, Candida famata, Candida duobushaemulonii. …”
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Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…(Lactobacillus (L.) crispatus, L. brevis and L. gasseri) against some ruminants’ pathogens. However, their possible beneficial effects on controlling the vaginosis caused by the use of intravaginal sponges for oestrus synchronisation have not been evaluated in in vivo models. …”
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Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival by Lucie Yeongran Ahn, Mark L. Cohen, Mark L. Cohen, Ignazio Cali, Ignazio Cali, Tia Russell, Jessica Ludwig, Xun Jia, Alberto Bizzi, Lawrence B. Schonberger, Ryan A. Maddox, Rohini Paul, Tania C. Ghazarian, Jaspreet Garcha, Mostafa Hammoudi, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby

“…Neuropathologic examination at autopsy revealed severe neuronal loss and gliosis with secondary white matter degeneration but minimal spongiform changes and PrP deposits in the cerebellum and neocortex by immunohistochemistry. Absence of pathogenic mutations and methionine/valine heterozygosity at codon 129 of the prion protein gene (PRNP), atypical type 1 protease-resistant PrP that lacks or shows underrepresentation of the diglycosylated PrP isoform by western blot analysis, and no acquired prion disease risk factors resulted in a final diagnosis of atypical sCJD. …”
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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression by Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin

“…The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. …”
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AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells by Inês Lua Freitas, Inês Lua Freitas, Inês Lua Freitas, Maria Fátima Macedo, Maria Fátima Macedo, Liliana Oliveira, Liliana Oliveira, Pedro Oliveira, Ana do Vale, Ana do Vale, Nuno M.S. dos Santos, Nuno M.S. dos Santos

“…These findings are relevant for both pathogenicity and biomedical contexts.…”
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Changing dynamics of bloodstream infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium in Germany, 2017–2023: a continued burd... by Simon Brinkwirth, Marcel Feig, Ines Noll, Tim Eckmanns, Achim Dörre, Sebastian Haller, Niklas Willrich

“…Conclusion MRSA and VREfm bloodstream infections followed different trends in the past and now present a comparable burden in Germany. Both pathogens pose a significant threat, particularly to hospitalised older aged men. …”
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Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

“…Both strains harbored virulence factors able to induce pathogenicity through immune evasion. The efflux pump genes (<i>adeF</i>, <i>rsmA</i>, and <i>qacG</i>) were present in the genomes of all the strains used in this study. …”
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Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…This present study reveals a significant causal relationship between mitochondria-associated proteins and SCZ, offering valuable insights into the disease’s pathogenicity and identifying potential therapeutic targets for drug development.…”
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Efficacy of hyperimmunized egg yolk antibodies (IgY) against Campylobacter jejuni: In Vitro and In Vivo evaluations by Nazanin Soltani, Shaban Rahimi, Pejvak Khaki, Mohammad Amir Karimi Torshizi, Bahareh Eskandari, Jesse Grimes

“…Campylobacter infections are a prevalent cause of diarrheal disease in humans and are the most significant zoonotic pathogens worldwide. Human campylobacteriosis is generally via ingestion of contaminated poultry products. …”
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