Characterization of Probiotic Abilities of Lactobacilli Isolated from Iranian Koozeh Traditional Cheese by Tavakoli Mahmoud, Hamidi-Esfahani Zohreh, Hejazi Mohammad Amin, Azizi Mohammad Hossein, Abbasi Soleiman

“…Five lactic strains of L. plantarum (MT.ZH193, MT.ZH393 and MT.ZH593) and L. fermentum (MT.ZH893 and MT.ZH993) inhibited the growth of the tested foodborne pathogens including Escherichia coli PTCC5052, Salmonella enterica, Enetrococcus hirea, Staphylococcus aureus and Pseudomonas aeruginosa.…”
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Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression by Li Xiang, Wenxu Pan, Huan Chen, Wenjun Du, Shuping Xie, Xinhua Liang, Fangying Yang, Rongwei Niu, Canxin Huang, Minan Luo, Yuxin Xu, Lanlan Geng, Sitang Gong, Wanfu Xu, Junhong Zhao

“…Microfold cells (M cells) are specific intestinal epithelial cells for monitoring and transcytosis of antigens, microorganisms, and pathogens in the intestine. However, the mechanism for M-cell development remained elusive. …”
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Comprehensive Analysis of <i>blaCTX-M1</i> Gene Expression Alongside <i>iutA</i>, <i>csgA</i>, and <i>kpsMII</i> Virulence Genes in Septicemic <i>Escherichia coli</i> Using Real-Ti... by Mohsen Karbalaei, Mojgan Esmailpour, Valentyn Oksenych, Majid Eslami

“…Real-time PCR revealed more expression levels in blood for the virulence genes <i>kpsMII</i> and <i>csgA</i>. Pathogenicity and resistance increased with <i>blaCTX-M1</i> co-expression with the <i>kpsMII</i> and <i>csgA</i> genes. …”
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Clinicopathological features of Lynch syndrome pedigrees with MSH2 c.351G>A gene variant by Shuai Zhang, Guanyu Fu, Gongping Sun, Yuanxin Tang, Jin Meng, Zhigang Wang, Rongjun Su, Wei Liu, Xiaoxia Li

“…To identify novel or rare pathogenic variants of MMR genes associated with LS, especially in Chinese pedigrees. …”
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Research note: The critical role of the interaction between Eimeria tenella invasion protein RON2 and host receptor annexin A2 in mediating parasite invasion by Junli Ni, Xiangjie Chen, Yunyun Sun, Yibin Zhu, Haiming Cai, Yongle Song, Minna Lv, Juan Li, Shenquan Liao, Nanshan Qi, Mingfei Sun, Jianfei Zhang, Youfang Gu, Xinchao Liu, Xuhui Lin

“…Avian coccidiosis, caused by protozoan parasites of the genus Eimeria, is a globally prevalent and highly pathogenic disease that poses a serious threat to the poultry industry, resulting in significant economic losses. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…The close connection and interaction between the cardiac and the liver functions are well-known, as cirrhotic cardiomyopathy is an important clinical entity which best describes the mutual pathogenical influence between these two organs. Due to the fact that cardiac dysfunction in patients with chronic hepatic disorders is oligosymptomatic or even asymptomatic, an early diagnosis represents a challenge for every physician. …”
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A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease by Rossana Scutari, Giulia Linardos, Stefania Ranno, Mara Pisani, Anna Chiara Vittucci, Luana Coltella, Luna Colagrossi, Velia Chiara Di Maio, Annamaria Sisto, Livia Mancinelli, Simona Landi, Sebastian Cristaldi, Massimiliano Raponi, Paola Bernaschi, Alberto Villani, Cristina Russo, Carlo Federico Perno

“…Methods From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms. …”
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Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated L... by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

“…Conclusions: In summary, this study unravels the intricate cellular diversity within hepatic immune cell populations, highlighting the pivotal immune pathogenic role of the GZMK+CD4+ T lymphocyte subset in ALD pathogenesis.…”
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Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

“…Due to the urgent demand for potent anti-metastatic agents, we aimed to determine the effects of sunitinib and novel analogs on the metastatic behavior of human CRC cells in hypoxic condition for the first time.MethodsFor in silico analyses, pathogenic targets of metastatic CRC were identified, PPI network was constructed and KEGG pathway enrichment analysis was conducted. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…However, the response of human cardiomyocytes to this pathogenic condition is currently unknown. In this work, we have set up a human cellular disease model of AL cardiac amyloidosis (AL-CA) in the form of cardiac spheroids, to study the cytotoxic effects of amyloidogenic LCs with regard to contractile function and calcium handling. …”
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Insights into quinoa endophytes: core bacterial communities reveal high stability to water stress and genotypic variation by Isaac Maestro-Gaitán, Miguel Redondo-Nieto, Sara González-Bodí, Laura Rodríguez-Casillas, Javier Matías, Luis Bolaños, María Reguera

“…Abstract Background Plant endophytes, comprising non-pathogenic bacteria, fungi, and archaea, inhabit various plant parts, including roots, stems, leaves, and seeds. …”
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Odyssey of environmental and microbial interventions in maize crop improvement by Alok Kumar Singh, Alok Kumar Singh, Alok Kumar Srivastava, Parul Johri, Manish Dwivedi, Radhey Shyam Kaushal, Mala Trivedi, Tarun Kumar Upadhyay, Nadiyah M. Alabdallah, Nadiyah M. Alabdallah, Irfan Ahmad, Mohd Saeed, Sorabh Lakhanpal

“…The interaction between these stresses is complex; for instance, abiotic stress can heighten a plant’s susceptibility to pathogens, while an overabundance of pests can exacerbate the plant’s response to environmental stress. …”
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Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and in vitro experiments by Jialiang Xin, Xingxing Song, Haohong Zheng, Wenjing Li, Yuyang Qin, Wei Wang, Wei Wang, He Zhang, Guangneng Peng

“…Network pharmacology analysis identified 26 potential targets through which SA could inhibit CHIKV, including key pathogenic targets such as TNF, IL-6, and MAPK3. This hypothesis was further supported by molecular docking. …”
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Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract by Eli Compaoré, Moussa Compaoré, Vincent Ouédraogo, Ablassé Rouamba, Alimata Bancé, Mignini R. Dofini, Martin Kiendrebeogo

“…Ageratum conyzoides is one of the antimicrobial medicinal plants that is being used to fight various multi-resistant pathogenic bacteria in Burkina Faso. Aim: The aim was to promote safe medicinal use of A. conyzoides by highlighting the anti-biofilm and anti-motility effects of its methanol extract. …”
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Human adenovirus species B knob proteins as immunogens for inducing cross-neutralizing antibody responses by Zhenwei Liu, Yuting Xian, Jixian Lan, Zhichao Zhou, Xiao Li, Rong Zhou, Dehui Chen, Xingui Tian

“…Our results provide insight into the immunogenicity of HAdV species B knob proteins.IMPORTANCEHuman adenovirus (HAdV) species B are common pathogens causing severe pneumonia in children, and there is currently no vaccine available. …”
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A SYBR green I-based multiplex real-time PCR for simultaneous detection of pseudorabies virus, porcine circovirus 3 and porcine parvovirus by Lihua Cao, Wenke Lv, Anqi Li, Lulu Yang, Feng Zhou, Feng Wen, Sheng Yuan, Shujian Huang, Zhili Li, Jinyue Guo

“…Results PRV, PPV and PCV3 were distinguished in the same sample by their different melting temperatures (Tm), with melting peaks at 90 °C for PRV, 84 °C for PPV and 80 °C for PCV3, respectively, and other non-targeted swine pathogens did not exhibit specific melting peaks. The assay showed a high degree of linearity (R2≧0.995), and the detection limits were 4.76 copies/μL for PRV, 3.67 copies/μL for PPV, 3.07 copies/μL for PCV3 and 1.87 × 102 copies/μL for the three mixed plasmids, respectively. …”
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Genomic insights into multidrug-resistant Acinetobacter baumannii strains isolated from Dhaka, Bangladesh by Sadia Ferdous, K M Shayerul Abedin Shayer, Afia Anjum, Sabbir R. Shuvo, Ishrat Jabeen, Kristi Paul Hridi, A.K.M. Imrul Hassan, Md Imran Khan, Mohammad Fazle Alam Rabbi, Mahmud Hossain, Kazi Nadim Hasan, Sohidul Islam

“…Acinetobacter baumannii is one of the most common nosocomial infections causing pathogens. Multidrug-resistant (MDR) A. baumannii is a growing concern to the healthcare system in Bangladesh, necessitating the elucidation of the genetic characteristics of this species. …”
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Isolation, Characterization, and Quantification of Bacteria from African Sausages Sold in Nairobi County, Kenya by W. H. Karoki, D. N. Karanja, L. C. Bebora, L. W. Njagi

“…Comprehensive study is needed to sample more eatery meat points in Nairobi and other areas in order to demonstrate pathogenic attributes of these isolates and establish the respective total aerobic bacterial count. …”
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Rapid and sensitive detection of Haemophilus influenzae using multiple cross displacement amplification combined with CRISPR-Cas12a-based biosensing system by Xinbei Jia, Wenjian Xu, Fei Xiao, Nan Jia, Xiaolan Huang, Yiqin Zhang, Juan Zhou, Yi Wang, Jun Tai

“…The assay was able to detect H. influenzae genomic DNA at concentrations as low as 50 fg and showed no cross-reactivity with non-H. influenzae pathogens. Furthermore, the Hi-MCDA-CRISPR assay successfully analyzed 65 clinical sputum samples. …”
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Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway by Weixu Chen, Mengtong Wu, Lin Du, Changhua Fang, Hao Wang, Wendi Wang, Chengwei Zhang, Hongqian Guo, Gutian Zhang

“…This study aimed to unravel the pathogenic mechanisms and uncover novel therapeutic targets. …”
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