Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock by David A. C. Messerer, Stephanie Denk, Karl J. Föhr, Rebecca Halbgebauer, Christian K. Braun, Felix Hönes, Julia Harant, Michael Fauler, Manfred Frick, Benedikt L. Nußbaum, Peter Radermacher, Sebastian Hafner, Markus S. Huber-Lang

“…Physiologically, exposure of PMN to the complement activation product C5a results in a protective response against pathogens, whereas in the case of systemic inflammation, excessive C5a substantially impairs neutrophil functions. …”
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Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments by Shujuan Li, Tao Jin, Hong-Liang Zhang, Hong Yu, Fanhua Meng, Hernan Concha Quezada, Jie Zhu

“…However, some changes in GBS could not be explained completely by Th1 cells pathogenic role. Recently, Th17 cells have been identified and can mediate tissue inflammation and autoimmune response. …”
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By activating endothelium histone H4 mediates oleic acid-induced acute respiratory distress syndrome by Yanlin Zhang, Jingjin Tan, Yiran Zhao, Li Guan, Shuqiang Li

“…Abstract Objective This study investigated pathogenic role and mechanism of extracellular histone H4 during oleic acid (OA)-induced acute respiratory distress syndrome (ARDS). …”
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Immunization‐related complex regional pain syndrome: A systematic review of case reports by William K. Copenhaver, Brandon J. Goodwin, Alexa Simonetti, Kunal P. Shah, Nicholas J. Averell, David F. Lo, Richard T. Jermyn

“…Abstract Aim Vaccines have been shown to have the highest efficacy in preventing infectious diseases through their ability to induce immunological memory against pathogens. An adverse reaction to a vaccine is an unexpected medical occurrence following immunization. …”
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Microalgae-based biofertilizers improve fertility and microbial community structures in the soil of potted tomato by Xiaotong Song, Jiayi Liu, Yanzhang Feng, Chengxu Zhou, Xiaohui Li, Xiaojun Yan, Roger Ruan, Pengfei Cheng

“…Microalgae-based fertilizers alter the abundance of soil bacteria and fungi, causing beneficial bacteria such as Thermonaerobaculia, Subgroup_10, Sordariomycetes, and Microascaceae to increase, while pathogenic bacteria like Pseudomonas, Togniniaceae, and Phaeoacremonium decreased. …”
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Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 by Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang

“…Abstract Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. …”
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Mature Tiankengs are biodiversity hotspots of soil microorganisms in the karst region by Junbo Yang, Xiaohui Wang, Keyi Wang, Danjuan Zeng, Ling Mo, Shuai Li, Baozhu Fang, Bhagwan Rekadwad, Wenjun Li, Gaozhong Pu

“…The microbial functions of human pathogenic, aromatic compounds and plastic degradation associated were higher in Tiankeng than in the outside. …”
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Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet by Meirong Wu, Xiaobin Wu, Jiangxiong Zhu, Fanglan Li, Xinlin Wei, Yuanfeng Wang

“…Moreover, GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria. More specifically, GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides, whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium. …”
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Advancing green recovery: Integrating one health in sustainable wildlife management in the Asia-Pacific Indigenous People and Local Communities by Nareerat Sangkachai, Anuwat Wiratsudakul, Delia G. Randolph, Maxine Whittaker, Acty George, Martin R. Nielsen, Nicholas Hogarth, Dirk U. Pfeiffer, Carsten Smith-Hall, P.O. Nameer, Latiffah Hassan, Gautam Talukdar, Tien Ming Lee, Vinod B. Mathur, Innocent B. Rwego, James Compton, Manon Mispiratceguy, Jianbin Shi, Amanda E. Fine, Illias Animon, Kristina Rodina de Carvalho, Andrew Taber, Scott Newman, Metawee Thongdee, Ladawan Sariya, Siriporn Tangsudjai, Waruja Korkijthamkul, Walasinee Sakcamduang, Sarin Suwanpakdee

“…The relationship between wildlife interactions and the emergence of pathogens that can be transmitted between wild animals, domestic and production animals, and humans underscores the need to incorporate a One Health approach to mitigate risk. …”
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The Role of Macrophages in the Pathogenesis of Celiac Disease by A. I. Khavkin, E. V. Loshkova, E. I. Kondratieva, N. S. Shapovalova, I. R. Grishkevich, I. V. Doroshenko, G. N. Yankina

“…Impaired macrophage function/differentiation results in either inadequate, excessive immune activation or failure to mount effective protective immune responses against pathogens, which may result in the development of gastrointestinal diseases. …”
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Prevalence of <i>Batrachochytrium dendrobatidis</i> in Amphibians in Northwestern Italy’s Protected Areas by Arianna Meletiadis, Matteo Riccardo Di Nicola, Stefano Bovero, Marco Favelli, Marzia Pezzolato, Stefania Grella, Giusi Rezza, Pier Luigi Acutis

“…While Bd was identified in the sampled amphibians, the exact cause of the observed mortality remains unclear and may involve other pathogens or multifactorial causes, including but not limited to Bd. …”
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Monitoring of Antimicrobial Susceptibility of Bacteria Isolated from Poultry Farms from 2014 to 2018 by Engy Ahmed Hamed, May Fathy Abdelaty, Hend Karam Sorour, Heba Roshdy, Mona Aly Abdelhalim AbdelRahman, Ola Magdy, Waleed Abdelfatah. Ibrahim, Ahmed Sayed, Hytham Mohamed, Mohammed Iraqi Youssef, Wafaa Mohamed Hassan, Heba Badr

“…The current situation of antibiotic resistance of most bacterial pathogens was a threat to the poultry and public health with increasing economic losses. …”
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Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes by Ying Yang, Tai-Cheng Zhou, Yong-Ying Liu, Xiao Li, Wen-Xue Wang, David M. Irwin, Ya-Ping Zhang

“…We demonstrated that mutation p.T130I in HNF4A was pathogenic as were the predicted polymorphisms p.I27L and p.S487N in HNF1A by genetic and functional analysis. …”
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The effect of cannabis-derived terpenes on alveolar macrophage function by Patrick M. Greiss, Patrick M. Greiss, Patrick M. Greiss, Jacquelyn D. Rich, Jacquelyn D. Rich, Jacquelyn D. Rich, Geoffrey A. McKay, Dao Nguyen, Dao Nguyen, Dao Nguyen, Dao Nguyen, Mark G. Lefsrud, David H. Eidelman, David H. Eidelman, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole

“…However, it is not known whether terpenes derived from cannabis alone or in combination with the cannabinoid ∆9-THC impacts the function of alveolar macrophages, a specialized pulmonary innate immune cell that is important in host defense against pathogens. Therefore, we investigated the immunomodulatory properties of two commercially-available cannabis terpene mixtures on the function of MH-S cells, a murine alveolar macrophage cell line. …”
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Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction by Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, Kazuhiro Satomi, Takeharu Hayashi

“…We performed a causative gene analysis in patients with a rare subtype of HCM, HCM with mid-ventricular obstruction (HCM-MVO), and identified four patients with different pathogenic variants of GLA, which were clinically confirmed as FD. …”
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Inherited Thrombocytopenia Related Genes: GPS2 Mediates the Interplay Between ANKRD26 and ETV6 by Valeria Capaci, Melania Eva Zanchetta, Giorgia Fontana, Daniele Ammeti, Roberta Bottega, Michela Faleschini, Anna Savoia

“…Furthermore, ANKRD26 overexpression deregulates ETV6 transcriptional repression, supporting a common pathogenic mechanism underlying ANKRD26-RT, FPD/AML, and ETV6-RT. …”
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Negative Effects of High Glucose Exposure in Human Gonadotropin-Releasing Hormone Neurons by Annamaria Morelli, Paolo Comeglio, Erica Sarchielli, Ilaria Cellai, Linda Vignozzi, Gabriella B. Vannelli, Mario Maggi

“…In conclusion, our findings demonstrate a deleterious direct contribution of high glucose on human GnRH neurons, thus providing new insights into pathogenic mechanisms linking metabolic disorders to reproductive dysfunctions.…”
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Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…By integrating evidence across disciplines, this review identifies critical knowledge gaps, including the biological pathways underlying <i>RNF213</i>’s pathogenicity. These insights lay the groundwork for future research and underscore the potential of <i>RNF213</i> in driving personalized approaches to cerebrovascular disease management.…”
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Synthesis of N-Methylmorpholinium Derivatives Possessing a 1,3,4-Oxadiazole Core as Feasible Antibacterial Agents against Plant Bacterial Diseases by Xinxin Tuo, Jie Yang, Yedong Zhang, Peiyi Wang

“…Bioassay results revealed that compounds 3l and 3i showed the strongest antibacterial activity toward pathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri with the lowest EC50 values of 1.40 and 0.90 μg/mL, respectively. …”
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Effects of Climatic, Chemical, and Cultural Control Strategies on Community Composition of Auchenorrhyncha and Population Dynamics of Two Major Green Leafhopper Pests in Peach Orch... by Patrícia Monteiro Nascimento, Ana Carina Neto, Vera Guerreiro, Anabela Barateiro, Hugo Anjos, José Pereira Coutinho, Marília Antunes, Maria Teresa Rebelo

“…A three-year study in two Mediterranean peach orchards monitored Auchenorrhyncha species, including the main vectors of plant pathogens causing significant economic losses. The research focused on the management of two polyphagous leafhoppers, <i>Asymmetrasca decedens</i> and <i>Hebata</i> (<i>Signatasca</i>) <i>solani</i>. …”
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