Population features of prevalence and clinical-diagnostic role of NOD2 gene polymorphisms associated with Crohn’s disease by D. A. Kuznetsova, M. V. Merzlyakov, G. V. Vavin, A. S. Razumov, V. L. Emanue

“…It will allow not only to increase efficacy of early diagnosis and the CD risk prognosis, but to define environmental factors affecting clinical utilization of genetic factors that is a premise for development of pathogenic justified management algorithm encompassing both populationbased and regional factors.…”
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Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus by Tingting Du, Dong Meng, Hongyan Cao, Yi Lian, Rui Wu, Tengyue Liu, Tianyi Wang, Cai Qin, Zhihua Song, Biying Dong, Yujie Fu, Qing Yang

“…Abstract Sorbitol is an important primary metabolite that serves as both a carbon source and signal to pathogens. The leaf diseases caused by Alternata alternata are particularly serious in crabapple (Malus micromalus). …”
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Species diversity of saprophagous flies (Diptera) in hospital grounds of Tehran, Iran by Abbas Ali Mirzakhanlou, Mansoureh Shayeghi, Hassan Vatandoust, Arman Izadian, Zahra Karimi, Kamran Akbarzadeh

“…Synanthropic flies are essential in transmitting various pathogens, producing myiasis, and their application in forensic entomology. …”
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Cross-protective effect of acid adaptation on ethanol tolerance in Salmonella Enteritidis by Shoukui He, Beining Ye, Zengfeng Zhang, Yan Cui, Siyun Wang, Xianming Shi

“…Cross protection can undermine the effectiveness of control measures on foodborne pathogens, and therefore brings major implications for food safety. …”
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Proximate Analysis, Antioxidant Activity, and Antibacterial Activity of Fish Sausages Fortified with Bee Bread Extract by Salma Malihah Mohammad, Amirun Afiq Badrul Hisham, Nur Atifa Mustapa, Kim Wei Chan, Norhasnida Zawawi

“…Based on the antibacterial activity, BBE was able to inhibit tested foodborne pathogens, and the addition of BBE in fish sausage showed total plate count below 6 log10 CFU/g within 6 days of frozen storage. …”
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Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment by Fangling Li, Chengjing Liu, Wenyi Gu, Qianhe Xu, Dongmei Li, Dongdong Cao, Zhiyong Liu

“…In addition, HA/GCV@ZIF-8 not only suppresses expression of KSHV pathogenic genes with less drug dose, but also inhibits the ability of cell proliferation and migration. …”
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The Molecular Diagnosis Protocols of New Coronavirus (COVID-19); Specificity and Sensitivity an Overview by Abdullah Ahmed Hama, Othman Abdulrahman Mohammed, Fatima Mahmud Ali, Osama Hamid Shareef, Sardar Muhammad Wli, Sabiha Sharif, Syamand Ahmed Qadir

“…In conclusion of this review, the RNA dependent RNA polymerase (RdRp) and RdRp/Hel protocols will be valuable to distinguish the  COVID-19 from the SARS-CoV and the other respiratory viral pathogens. …”
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A review of metabolic calorimetric applications in plant stress, waste management, and diagnostics by Michael Bayode, Ifeoluwaposi Ogundana, Oluwatosin Ogundare, Elizabeth Awodire, Patience Abbah, Israel Onifade, Adeola Adeyolanu, Stephen Okunade, Samuel Ogboye, Michael Elabiyi

“…IMC not only enhances our understanding of plant responses to stress and pathogens but also aids in achieving Sustainable Development Goal (SDG) 3 by enhancing diagnostic capabilities and disease management. …”
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The Combination of Host-Associated Bacillus megaterium R32 and Stachyose Promotes the Intestinal Health of Turbot (Scophthalmus maximus. L) by Yaoyao Kong, Sifan Zhao, Weihao Ou, Kangsen Mai, Yanjiao Zhang

“…The results showed that diets RS and RC significantly inhibited the expression of cell development and apoptosis-related genes (β-catenin, CyclinD1, BAX, Bid); diets RS and RC significantly increased the expression of intestinal tight junction protein claudin-4, while RS group significantly decreased the expression of myosin light chain kinase; diets RS and RC significantly decreased the expression of proinflammatory factors (IL-13, IL-15, IFN- γ), diet RS also significantly decreased the expression of TNF-α and AP-1, and increased the expression of TGF-β. 16s rRNA gene sequencing results showed that diets RS and RC significantly decreased the abundance of conditional pathogenic bacteria (Corynebacterium, Desulfovibrio, Escherichia-Shigella). …”
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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…The HFD-Renin mouse model recapitulates key features of human HFpEF and will enable studies dissecting the contribution of individual pathogenic drivers to this complex syndrome. Additional preclinical HFpEF models allow for orthogonal studies to increase validity in assessment of interventions.…”
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The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients by Tiantian Chen, Xiaoxia Hou, Yingmeng Ni, Wei Du, Huize Han, Youchao Yu, Guochao Shi

“…Treg cells play an important role in the pathogenic progress of asthma. Objective. To address the alterations of Treg cells in asthma. …”
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Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress by Linmin Zhong, Qiling Yang, Yiming Shao, Shanwen Hu, Lianxian Guo

“…Therefore, this study aims to investigate the combined effects and underlying pathogenic mechanisms of concurrent exposure to these two hazardous factors by establishing a mouse model that is infected with H. pylori and exposed to inorganic arsenic through drinking water. …”
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Ecoepidemiology of Chagas Disease in a Biological Corridor in Southeastern Mexico: A Promising Approach to Understand the Risk of Chagas Disease by Ingrid Yazmin Cruz-Alegría, Nancy Gabriela Santos-Hernández, Christian Ruiz-Castillejos, Juan Felipe Ruan-Soto, Adriana Moreno-Rodríguez, Any Laura Flores-Villegas, Javier Gutiérrez-Jiménez, Luis Arturo Hernández-Mijangos, Eduardo Estanislao Espinoza-Medinilla, Dolores Guadalupe Vidal-López, José Antonio De Fuentes-Vicente

“…Particularly in vector-borne diseases, the study under this approach offers us an overview of the pathogens, vectors, and hosts that coexist in a given region and their ecological determinants. …”
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Epidemiology and transmission patterns of Cryptosporidium spp., and Giardia duodenalis within a One Health framework in rural areas of Eastern Algeria by Sadiya Maxamhud, Nassiba Reghaissia, AbdElKarim Laatamna, Eleni Gentekaki, Anastasios D. Tsaousis

“…Gastrointestinal infections constitute a significant global health concern, particularly in tropical and subtropical regions, caused by various pathogens. Among these, Cryptosporidium spp. and Giardia duodenalis are noteworthy due to their zoonotic potential. …”
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The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase by Elena Luppi, Monica De Luise, Carla Bini, Guido Pelletti, Gaia Tioli, Ivana Kurelac, Luisa Iommarini, Susi Pelotti, Giuseppe Gasparre

“…No known or novel mtDNA pathogenic variants were found. Two rRNA and 8 missense variants were rarer than polymorphisms as they had a frequency lower than 1% in population databases. 5/8 missense variants clustered in ATP synthase genes and 4/8 missense variants were previously detected in patients with suspected mitochondriopathy. …”
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Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling by Kevser Kübra Kırboğa, Aman Karim, Ecir Uğur Küçüksille, Mithun Rudrapal, Johra Khan, Raghu Ram Achar, Ekaterina Silina, Natalia Manturova, Victor Stupin

“…The proteins investigated included Glycosylphosphatidylinositol (GPI), Enolase, Mannitol-2-dehydrogenase, GMP synthase, Dihydroorotate dehydrogenase (DHODH), Heat shock protein 90 homolog (Hsp90), Chitin Synthase 2 (CaChs2), and Mannitol-1-phosphate 5-dehydrogenase (M1P5DH), all of which play crucial roles in fungal survival and pathogenicity. This research evaluates the binding affinities and interaction profiles of selected cannabinoids and stilbenoids with these eight proteins using molecular docking and molecular dynamics simulations. …”
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A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

“…In this study, we describe a pathogenic nonsense mutation located in POU4F3 in a four-generation Chinese family. …”
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Effects of Acidification and Preservatives on Microbial Growth during Storage of Orange Fleshed Sweet Potato Puree by Joyce Ndunge Musyoka, George Ooko Abong', Daniel Mahuga Mbogo, Richard Fuchs, Jan Low, Simon Heck, Tawanda Muzhingi

“…Combination of chemical preservatives and acidification is effective in inhibiting pathogens and spoilage microorganisms in sweet potato puree.…”
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Preliminary species diversity and community phylogenetics of wood-inhabiting basidiomycetous fungi in the Dabie Mountains, Central China reveal unexpected richness by Xiang-Yang Liu, Shi-Liang Liu, Hao-Wen Wei, Xue-Wei Wang, Jia Yu, Shan Shen, Li-Wei Zhou

“…These species belonged to two classes, 11 orders, 42 families, and 106 genera of Basidiomycota, and included 12 edible species, 28 medicinal species, four poisonous species, and seven forest pathogens. Four types of fungal distribution pattern at the genus level were recognized for 65 genera, while another 41 genera could not be placed in any known distribution pattern. …”
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Assessing the antiproliferative effect of biogenic silver chloride nanoparticles on glioblastoma cell lines by quantitative image‐based analysis by Nathalia Müller, Mateus Eugenio, Luciana F. Romão, Jorge Marcondes de Souza, Soniza V. Alves‐Leon, Loraine Campanati, Celso Sant’Anna

“…Silver nanoparticles (AgNPs) have been shown to exhibit biocidal activity in a variety of microorganisms, including some pathogenic microorganisms. Herein, the antiproliferative effect of AgCl‐NPs on glioblastoma cell lines (GBM02 and GBM11) and on astrocytes was evaluated through automated quantitative image‐based analysis (HCA) of the cells. …”
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