Clinical phenotype and trio whole exome sequencing data from a patient with glycogen storage disease IV in Indonesia(NCBI) by Ivan William Harsono, Yulia Ariani, Beben Benyamin, Fadilah Fadilah, Dwi Ari Pujianto, Cut Nurul Hafifah, Titis Prawitasari

“…This often results in delayed diagnosis, typically 5.6 to 7.6 years later, with only 50% of cases being diagnosed, while the remaining cases are classified as undiagnosed rare diseases due to either the absence of identifiable potential variants or the presence of novel variants requiring further functional studies to confirm their pathogenicity. Proband and trio whole exome sequencing analysis remains a cost-effective and widely available method for diagnosing rare diseases detecting between 21 and 40% of cases. …”
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TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. …”
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Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A Double-Blind, Randomized, Placebo-Control... by M. Ratna Sudha, Jayanthi Neelamraju, M. Surendra Reddy, Manoj Kumar

“…It is now suggested that probiotic usage prevents the overgrowth of these pathogenic microbes, thereby reducing caries activity. …”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Furthermore, zinc supplementation improved gut microbiome composition, promoting beneficial bacteria and reducing pathogenic growth. Clinical studies confirmed its effectiveness in reducing respiratory infections, improving vaccine responses, and decreasing complications in vulnerable individuals. …”
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Detection of Viable but Nonculturable E. coli Induced by Low-Level Antimicrobials Using AI-Enabled Hyperspectral Microscopy by MeiLi Papa, Aarham Wasit, Justin Pecora, Teresa M. Bergholz, Jiyoon Yi

“…Rapid detection of bacterial pathogens is essential for food safety and public health, yet bacteria can evade detection by entering a viable but nonculturable (VBNC) state under sublethal stress, such as antimicrobial residues. …”
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans by Michela Palmieri, Spyridoula Maraka, Horace J. Spencer, Jeff D. Thostenson, Katherine Dishongh, Micheal Knox, Betty Ussery, Jesse Byrd, Jacqueline K. Kuipers, Sanaz Abedzadeh-Anaraki, Chitharanjan Duvoor, Yuanjie Mao, Lakshmi Menon, James S. Williams, Stavros C. Manolagas, Robert L. Jilka, Elena Ambrogini

“…It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. …”
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A preliminary evaluation of a fast, low-cost, and high-throughput nucleic acid extraction method for bacterial microbiota profiling in low-microbial biomass samples by Xiangning Bai, Simon Rayner, Linda Ellevog Skuggen, Kine Kragl Engseth, Pål Marius Bjørnstad, Marianne Dalland, Gregor D. Gilfillan, Magnar Bjørås, Andreas Matussek

“…Our pilot study indicates the potential of the NAxtra protocol for bacterial microbiota characterization of low-microbial biomass samples and supports a more comprehensive study to fully evaluate the value of the NAxtra protocol in microbiota research and clinical diagnostics of respiratory pathogens.…”
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Microbiological Quality and Risk Assessment for Aflatoxins in Groundnuts and Roasted Cashew Nuts Meant for Human Consumption by Modupeade Christianah Adetunji, Ogechi Precious Alika, Ngozi Precious Awa, Olusegun Oladimeji Atanda, Mulunda Mwanza

“…The moisture content, colony counts, incidence of pathogenic bacteria, aflatoxin contamination, and risk assessment for aflatoxins were evaluated using standard methods. …”
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Identification of a Fetal De Novo Splice Variant in ARCN1 Associated With Growth and Skeletal Abnormalities by Wencong He, Zejun Yang, Jianjian Cui, Ruilin Ma, Hui Tao, Yanan Li, Yin Zhao, Yang Pan, Jue Li

“…The clinical and genetic data of a fetus with a complex combination of clinical signs and a novel de novo heterozygous variant were collected and have been summarized in this study. The potential pathogenic variant was identified throughout the whole exome sequencing and the effects of candidate variants were further validated by a minigene splicing assay. …”
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Prevalence and Antimicrobial Resistance of Escherichia coli Isolated from Various Meat Types in the Tamale Metropolis of Ghana by Frederick Adzitey, Prince Assoah-Peprah, Gabriel A. Teye, Anou M. Somboro, Hezekiel M. Kumalo, Daniel G. Amoako

“…Meats are important potential sources of foodborne pathogens including Escherichia coli. This study was conducted to determine the prevalence and antimicrobial resistance of Escherichia coli isolated from meats in the Tamale metropolis of Ghana. …”
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Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota by Bowen Li, Mingming Liu, Wenjing Du, Shuaidong Wang, Zekang Xu, Xiaoqian Zhang, Yang Zhang, Song Hua

“…Additionally, there was a notable upsurge in inflammatory factors within the affected tissues. 16 S rDNA sequencing revealed alterations in the colonic microbiota, including a decrease in the abundance of beneficial bacteria such as Corynebacterium_glutamicum and Candidatus_Saccharimonas, and an increase in the abundance of potential pathogens like Lachnospiraceae_NK4A136_group and Escherichia-Shigella. …”
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The regulation of tobacco growth under preceding crop planting: insights from soil quality, microbial communities, and metabolic profiling by Peiyan Zhao, Houfa Zhou, Xiaolin Liao, Leifeng Zhao, Yuanxian Zheng, Tiane Xiong, Gaorun Zhang, Sirong Jiang, Jiming Wang, Yuansheng He, Jiangtao Li, Jieying Zhu, Yongjun Zhang, Yanrun Li, Fuzhao Nian, Di Liu

“…In contrast, the preceding crop of maize reduced plant pathogenic fungi and promoted positive microbial interactions. …”
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Anaerobic Bacteremias in Left Ventricular Assist Devices and Advanced Heart Failure by David R. Murillo-Garcia, Julian Galindo, Natalia Pinto, Gabriel Motoa, Esther Benamu, Carlos Franco-Paredes, Daniel B. Chastain, Andrés F. Henao-Martínez

“…Bacteremias caused by anaerobic pathogens in patients with LVAD are underreported. …”
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In Vivo Effectiveness of <i>Pleurotus ostreatus</i> in Degradation of Toxic Metabolites of Filamentous Fungi Such as Aflatoxin B1 and Zearalenone by Agnieszka Zapaśnik, Marcin Bryła, Adrian Wojtczak, Barbara Sokołowska

“…Biological methods of food preservation are an alternative option to conventional chemical and physical methods, characterized by their less negative impact on human health as well as their high efficiency against filamentous fungi and other foodborne pathogens. Mycoremediation is a new biotechnique based on the capability of fungi to detoxify matrices from various pullulans. …”
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DETECTION OF PANTON-VALENTINE LEUKOCIDIN (PVL) GENE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN DIABETIC ULCER PATIENTS by Prisma Anjarlena, Suliati, Wisnu Istanto, Retno Sasongkowati

“…Panton-Valentine Leukocidin (PVL) is a crucial factor of S. aureus pathogenicity. Skin and soft tissue infections can be caused by the PVL gene. …”
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Clinical, Radiographic, and Molecular Analysis of Patients with X-Linked Hypophosphatemic Rickets: Looking for Phenotype–Genotype Correlation by Marco A. Olivas-Valdez, Armando Blanco-López, Daniela Velázquez-Arestegui, Teresita Vera-Zazueta, Douglas Colmenares-Bonilla, Lilian Reyes-Morales, Miguel A. Blanco-Uriarte, Lucero Monterde-Cruz, Alberto Hidalgo-Bravo

“…A total of 56 different pathogenic variants were found among the study population; from them, 31 variants have not been previously reported. …”
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Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…ARG repression also worked in a pathogenic strain grown in human urine, as a demonstration of CRISPRi-mediated re-sensitization in host-mimicking media. …”
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Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars by R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda

“…Thus, the Siberian minipig genome has a considerable number of type A PERVs, conceivably pathogenic to humans. It is necessary to select animals with minimum PERV numbers in the genome for xenografting. …”
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A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…Abundantly expressed in the brain and involved in a broad range of cellular processes, PPP2R5D plays an essential role in modulating key neuronal pathways and signalling. Pathogenic mutations in the PPP2R5D gene are linked to clinical symptoms characterized by neurodevelopmental delay, intellectual disability, and autism spectrum disorders. …”
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Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…Plant secondary metabolites typically exhibit broad-spectrum antifungal activity without selective toxicity against pathogens. However, only a small fraction of antifungal metabolites have been identified from the tens of thousands of known plant secondary metabolites. …”
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