The Anti-Inflammatory Effect of Callicarpa nudiflora Extract on H. Pylori-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1β Signaling Axis by Lili Li, Bo Bao, Xingxing Chai, Xiaoyu Chen, Xiaohua Su, Shixiu Feng, Xiaohui Zhu

“…Helicobacter pylori (H. pylori) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. …”
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Lewy body diseases and the gut by Timothy R. Sampson, Malú Gámez Tansey, Andrew B. West, Rodger A. Liddle

“…Recent experimental and human observational studies raise the possibility that pathogenic alpha-synuclein (⍺-syn) might develop in the GI tract and subsequently spread to susceptible brain regions. …”
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Current treatment modalities for dry eye disease by E.B. Tatarnikova, O.I. Krivosheina

“…&nbsp;Krivosheina</b> </p> <p> <b>Siberian State Medical University, Tomsk, Russian Federation</b> </p> <p> <i>For many years, dry eye disease (DED) is a common ophthalmic condition associated with ocular surface damage and loss of homeostasis of the tear film. The key pathogenic factors of DED are tear film instability and tear hyperosmolarity, ocular surface inflammation and damage, and neurosensory alterations. …”
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Biorefinery—inspired, two-step valorization strategy to manage plant-based recalcitrant organic waste, involving solvent extraction, and fermentation with Bacillus clausii—a proof... by Sreejith Meppoyilam, Ajith Madhavan, Chinchu Bose, Jayasree Pooja, Swetha Suresh, Bipin G. Nair, Sanjay Pal

“…Different recalcitrant plant organic wastes resulting from four plants (Cocos nucifera, Allium cepa, Artocarpus hirsutus and Swietenia mahagoni) were used as feedstocks in the preliminary exploratory study using chosen pathogenic bacteria. Onion peel (Allium cepa) ethyl methyl ketone extract was chosen for further studies, as it inhibits Salmonella enterica, which is associated with infection and malodour (due to biogenic H2S) in wastewater. …”
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Incidence of Rod Shaped Gramnegative Hospital Acquired Bacterial Infection and Antibiotic Resistance: A Retrospective Based Population Study by Kamal Jalal Rashid

“…The most common bacteria separatedd from wound and sepsis were Pseudomonas aeruginosa 91.91%. Individual pathogens’ incidence differ significantly between location of infection p<0.001. …”
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Complete Genome Sequencing of Polar Arthrobacter sp. PAMC25284, Copper Tolerance Potential Unraveled with Genomic Analysis by Jayram Karmacharya, Prasansah Shrestha, So-Ra Han, Hyun Park, Tae-Jin Oh

“…The genus Arthrobacter is a known group of Gram-positive, opportunistic pathogenic bacteria from cold climates, with members that are believed to play a variety of roles at low temperatures. …”
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Gut microbiota in patients with sarcopenia: a systematic review and meta-analysis by Guangning Wang, Yujie Li, Huisong Liu, Xinjuan Yu

“…We also found more abundance of phylum Proteobacteria and genus Escherichia-Shigella, and less abundance of phylum Firmicutes and genus Faecalibacterium, Prevotella 9, Blautia in the sarcopenia group.ConclusionThe gut microbiota composition in patients with sarcopenia has undergone alterations, serving as a fundamental reference for further investigation into the potential pathogenic mechanisms and treatment strategies for sarcopenia.…”
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Chronic glomerulonephritis of the mixed type in patient with HBV-infection (<i>Clinical case</i>) by V. S. Adonyeva, A. B. Botchkarev, O. S. Saurina

“…Extrahepatic manifestations of viral hepatites frequently not only mask liver disease, but determine prognosis in many respects as well. Pathogenic treatment of НВV-infection associated CGN without antiviral treatment is accompanied by risk of liver disease activation. …”
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Identifying unstable CNG repeat loci in the human genome: a heuristic approach and implications for neurological disorders by Varun Suroliya, Bharathram Uppili, Manish Kumar, Vineet Jha, Achal K. Srivastava, Mohammed Faruq

“…The genes with these highly variable repeats also exhibited higher gene expression levels in the brain according to the tissue expression dataset (GTEx). No pathogenic expansion events were identified in patient samples, which is a limitation given the size of the patient group examined; however, these loci contain potential risk alleles for expandability. …”
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Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages. by Girish Ramachandran, Darren J Perkins, Patrick J Schmidlein, Mohan E Tulapurkar, Sharon M Tennant

“…Typhimurium ST313 strains are phenotypically different to ST19 strains and instead share similar pathogenic characteristics with typhoidal Salmonella serovars.…”
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Antibiotic use on crops in low and middle-income countries based on recommendations made by agricultural advisors by Philip Taylor, Robert Reeder

“…Relative to medical and veterinary use the quantities used globally are comparatively small, but this niche does provide some unique avenues by which resistance could develop in human pathogens. Results presented here have implications for those wanting to limit the spread of antibiotic resistance.…”
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Frequency Of Bacterial Co-Infections Isolated from Covid-19 Positive Patients From Tertiary Care Hospital Of Karachi by Fouzia Zeeshan Khan, Ambreen Fatima, Hareem Gohar, Mehwish Sajjad, Mona Siddiqui, Saima Naseem

“…The majority of these are multidrug-resistant pathogens, therefore, urgent action is required to control the spread of nosocomial infections by resistant strains, which are responsible for the high mortality rate among COVID-19 critical patients. …”
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Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) by Narendra Kumar Chaudhary, Parashuram Mishra

“…The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin.…”
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Phenotypic and molecular characterization of the largest worldwide cluster of hereditary angioedema type 1. by Juan Sebastian Arias-Flórez, Sandra Ximena Ramirez, Bibiana Bayona-Gomez, Lina Castro-Castillo, Valeria Correa-Martinez, Yasmín Sanchez-Gomez, William Usaquén-Martínez, Lilian Andrea Casas-Vargas, Carlos Eduardo Olmos Olmos, Nora Contreras Bravo, Camilo Andres Velandia-Piedrahita, Adrien Morel, Rodrigo Cabrera-Perez, Natalia Santiago-Tovar, Cristian Camilo Gaviria-Sabogal, Ingrid Tatyana Bernal, Dora Janeth Fonseca-Mendoza, Carlos M Restrepo

“…It is a highly variable, insidious, and potentially life-threatening condition, characterized by sudden local, often asymmetric, and episodic subcutaneous and submucosal swelling, caused by pathogenic molecular variants in the SERPING1 gene, which codes for C1-Inhibitor protein. …”
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Microbiological tests of fresh bull semen collected at breeding establishment by M. A. Sushkova, I. Ya. Stroganova, S. А. Schislenko

“…Other test parameters (total microbial count, coliform count) were within admissible limits. № anaerobes and pathogenic fungi were detected. Four Pseudomonas aeruginosa isolates and three Proteus vulgaris isolates recovered during the test have demonstrated susceptibility to ciprofloxacin that can be used for etiotropic treatment of bulls identified as bacteria carriers.…”
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Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production by Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh

“…Results The engineering targets included the deletion of the lacZ gene to prevent lactose metabolism interference, introduction of α-1,2-fucosyltransferase derived from the non-pathogenic strain, and optimization of the GDP-L-fucose biosynthesis pathway through the overexpression of manA and manC. …”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Moreover, dysbiosis in MS involves more pathogenic bacteria and fewer beneficial taxa, further influencing disease progression. …”
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Synthesis and anti-microbial evaluation with in silico studies of novel 2-aminothiazole benzohydrazide derivatives by S. Amrutha, Paramita Das, Anjali Nayak, Supratip Laha, Sharmina Begum, Sakshi Bhardwaj

“…This study aimed to synthesize various derivatives of (Z)-4-(2-aminothiazol-5-yl)-N-benzohydrazide (DT01-DT10) that are effective against a wide variety of anti-bacterial and antifungal pathogens. Results The binding energy of the compounds ranged from − 9.0 to − 10.0 kcal/mol. …”
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Epigenetic regulation of the nuclear genome associated with mitochondrial dysfunction in Leber’s hereditary optic neuropathy (LHON) by Aswathy P. Nair, Ambika Selvakumar, Janani Gopalarethinam, B. Abishek Kumar, Balachandar Vellingiri, Mohana Devi Subramaniam

“…One of the most common locations for deadly pathogenic mutations in humans is the human complex I accessory NDUFS4 subunit gene. …”
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Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity by David C. Stirling, Maria de Miguel Ferrer, Sungwon Kim, Madina Wane, Daniel Kysh, Lisa J. Caproni, John S. Tregoning

“…The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored for several other pathogens. DNA vaccines have potential advantages over RNA, including cost of manufacture, ease of storage and potentially lower reactogenicity. …”
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