New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications by Eva Sticova, Milan Jirsa, Joanna Pawłowska

“…Thus far, five representatives of PFIC (named PFIC1-5) caused by pathogenic mutations present in both alleles of ATP8B1, ABCB11, ABCB4, TJP2, and NR1H4 have been described. …”
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Histopathological characterization of skin and muscle lesions induced by lionfish (Pterois volitans) venom in a murine experimental model by Cecilia Díaz, Arturo Chang-Castillo, Natalia Ortiz

“…This is the case of an abundant protein, present in venom, with homology to a Golgi-associated plant pathogenic protein 1-like (GAPR1), which belongs to the same protein superfamily as venom CRISPs and insect allergens. …”
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Optimized Synthesis of Magnesium Oxide Nanoparticles as Bactericidal Agents by Mohammad Moslem Imani, Mohsen Safaei

“…According to the results, magnesium oxide nanoparticles can significantly reduce the number of Gram-positive and Gram-negative bacteria and can be used as an appropriate alternative to commonly used antibacterial compounds in order to tackle drug resistance among pathogens.…”
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Seropositivity for Bovine Viral Diarrhea and Enzootic Bovine Leukemia viruses in Blanco Orejinegro cattle in Colombia and infection associated-factors by A. Saldarriaga-Saldarriaga, M. Londoño-Gil, L. G. González-Herrera, J. C. Rincón-Flórez, A. López-Herrera

“…A sample of 4 ml of blood was taken from each animal to extract plasma and make indirect Elisa tests to detect antibodies against both pathogens. General seropositivity of 27,1% was obtained for EBL, finding as factors associated with seropositivity the inadequate disposition of placental tissues after delivery of the cows and the non-performance of serological tests on new animals entering the herd. …”
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hsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family by H. W. Cayatineto, S. T. Hakim

“…These viruses cause diseases ranging from mild to severe and are considered important human pathogens. MicroRNAs (miRNAs) are non-coding molecules involved in growth, development, cell proliferation, protein synthesis, apoptosis, and pathogenesis. …”
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INLUENCE OF ALIEN GENETIC MATERIAL ON THE MANIFESTATION OF AGRONOMICALLY IMPORTANT TRAITS OF COMMON WHEAT (T. aestivum L.) by I. N. Leonova

“…Although resistance genes have a prolonged protective efect on donor plants against diverse populations of pathogens, the introgression of target loci into the genome of common wheat can result in a signiicant decrease in the eiciency of the genes – up to complete loss of expression. …”
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Identification of Environmental Determinants Involved in the Distribution of Burkholderia pseudomallei in Southeast Asia using MaxEnt software. by Jose Francis V Abrantes, Zenn Ashley P Cariño, Hozeo Luis S Mercado, Fatima N Vicencio, Gio Ray S Sosa, Miguel Angelo M Habaña, Nikki Heherson A Dagamac

“…This study aimed to determine the environmental variables that would predict the most suitable ecological niche for this pathogenic bacterium in SEA by maximum entropy (MaxEnt) modeling. …”
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Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning by ZhanQiang Xie, YongLi Situ, Li Deng, Meng Liang, Hang Ding, Zhen Guo, QinYing Xu, Zhu Liang, Zheng Shao

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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…In this study, we evaluate the activity of the triphenylmethane (TPM) class of compounds against three species of Leishmania which are pathogenic in humans. The TPM have a history of safe use in humans, dating back to the use of the original member of this class, gentian violet (GV), from the early 20(th) century. …”
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Quality of phytopathometric variables generated from a ranking scale for the CABMV-passionfruit pathosystem by Antonio Carlos Mota Porto, Mariana de Lima Santos, Antonio Carlos Oliveira

“…The Cowpea aphid-borne mosaic virus (CABMV) is one of the most important pathogenic agents in passionfruit culture, causing extensive loss throughout the national territory. …”
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Association between Single Nucleotide Polymorphisms rs3757318 and Vitamin D Deficiency in Iraqi Breast Cancer Patients by Istikrar M. Hade, Ahmed S. K. Al-Khafaji, Fadhel M. Lafta, Yasir B. Qaddoori

“…Objectives: To assess the potential association between rs3757318 SNP and breast cancer pathogenicity, specifically in relation to serum vitamin D levels. …”
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Bacterial Colonization in the Airways and Intestines of Twin and Singleton Preterm Neonates: A Single-Center Study by Jiawei Yao, Tao Ai, Lei Zhang, Wei Tang, Zijin Chen, Yuedong Huang, Yinghong Fan

“…The top ten genera were Streptococcus, Acinetobacter, Ralstonia, Staphylococcus, Comamonas, Enterococcus, Stenotrophomonas, Dechlorosoma, Sphingopyxis, and Rothia. Potentially pathogenic and highly stress-tolerant Gram-negative bacteria were predominant in the intestinal flora. …”
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A Dynamic Model of Information-Vaccination-Disease That Accounts for Emerging Viral Variants: Model Development and a Case Study for COVID-19 in Iceland by Laijun Zhao, Mingmin Ying, Ying Qian, Lixin Zhou, Pingle Yang

“…Pathogens mutate as diseases spread, and variants that become epidemic or pandemic strains have higher transmission rates and a greater capacity to escape vaccine protection. …”
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Myricetin exposure reduces PC differentiation in vitro in primary human B cells by Shabirul Haque, Betty Diamond

“…Blocking or reducing PC differentiation is one approach to treat autoimmune diseases that are characterized by the presence of pathogenic autoantibodies. Recent studies have suggested the potential of myricetin, a natural flavonoid with anti-inflammatory and antioxidant properties, to block or reduce PC differentiation. …”
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Pleiotropic effects of a recessive Col1a2 mutation occurring in a mouse model of severe osteogenesis imperfecta. by Michelangelo Corcelli, Rachel Sagar, Ellen Petzendorfer, Mohammad Mehedi Hasan, Fleur S van Dijk, Anna L David, Pascale V Guillot

“…In Europe, approximately 85-90% of individuals with Osteogenesis Imperfecta (OI) have dominant pathogenic variants in the Col1a1 or Col1a2 genes whilst for Asian, especially Indian and Chinese cohorts, this ratio is much lower. …”
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Phytochemicals from Pyrrosia longifolia (Burm. f.) C.V. Morton with antibacterial activity by Hilwan Yuda Teruna, Rohimatul Khodijah, Neni Frimayanti, Rudi Hendra

“…The compounds exhibited antibacterial activity against several pathogenic bacteria, with MIC and MBC values ranging from 7.8 to 250 μg/mL. …”
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Anti-oxidation enhancement, inflammation alleviation, and microbial composition optimization of using tussah (Antheraea pernyi) silk fibroin peptides for hyperglycaemia remission. by Rui Mi, Xuejun Li, Yajie Li, Xingfan Du

“…Besides, the supplementation of TSFP presented a greater ability to shape and optimize the gut microbial composition by enriching the profitable bacteria and inhibiting the pathogenic microorganisms. Correlation analysis also revealed that the abundances of functional bacteria in the TSFP-treated groups exhibited better correlations with serum parameters, which would be of positive significance for blood glucose regulation and inflammation remission.…”
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Infections in systemic lupus erythematosus: A study of incidence and risk factors in 100 patients from western India by Ankan Jha, Tridip Das, Sunilkumar Rajmani Singh, Jyotsna Oak

“…Episodes of infection and pathogens isolated were recorded. Results: A total of 100 patients with SLE were evaluated (94 females and 6 males). …”
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The Role of TLR4 on B Cell Activation and Anti-β2GPI Antibody Production in the Antiphospholipid Syndrome by Si Cheng, Haibo Wang, Hong Zhou

“…High titer of anti-β2-glycoprotein I antibodies (anti-β2GPI Ab) plays a pathogenic role in antiphospholipid syndrome (APS). …”
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The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic by Nighina M. Khodzhaeva, Alla M. Baranova, Anatoly K. Tokmalaev

“…The imbalance of cytokine profile is an important pathogenic factor in the development of severe and recurrent forms of the disease, since the formation of a defective immune response to parasitic antigens contributes to adverse outcomes. …”
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