A Pilot Study of Exosome Proteomic Profiling Reveals Dysregulated Metabolic Pathways in Endometrial Cancer by Feras Kharrat, Valeria Capaci, Andrea Conti, Valentina Golino, Pietro Campiglia, Nour Balasan, Michelangelo Aloisio, Danilo Licastro, Lorenzo Monasta, Federica Caponneto, Antonio Paolo Beltrami, Federico Romano, Giovanni di Lorenzo, Giuseppe Ricci, Blendi Ura

“…<b>Background/Objectives</b>: Endometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of the disease are still unknown. …”
Get full text

Study on fungal contaminants in aborted calves of cattle herds in Iran by Samaneh Eidi, Hesam A. Seifi, Soheil Sadr, Hamideh Zeinali

“…., were identified, indicating a diverse range of pathogens affecting calves. The specificity of fungal contaminants in certain organs, such as C. neoformans, Rhodotorula spp. and Trichosporon spp., highlighted the organ's microenvironment as a potential factor influencing fungal growth. …”
Get full text

Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258 by Prashantkumar Siddappa Chakra, Aishwarya Banakar, Shriram Narayan Puranik, Vishwas Kaveeshwar, C. R. Ravikumar, Devaraja Gayathri

“…Furthermore, the synthesized nanoparticles displayed significant antibacterial activity against selected human pathogens, with the biggest inhibition zone observed against Staphylococcus aureus (22 ± 0.57 mm) and the smallest inhibition zone observed against Salmonella enterica serovar typhi (3 ± 1 mm). …”
Get full text

In vitro long-term exposure to chlorhexidine or triclosan induces cross-resistance against azoles in Nakaseomyces glabratus by Kathrin Spettel, Dominik Bumberger, Richard Kriz, Sarah Frank, Madita Loy, Sonia Galazka, Miranda Suchomel, Heimo Lagler, Athanasios Makristathis, Birgit Willinger

“…Abstract Background Topical antiseptics are crucial for preventing infections and reducing transmission of pathogens. However, commonly used antiseptic agents have been reported to cause cross-resistance to other antimicrobials in bacteria, which has not yet been described in yeasts. …”
Get full text

Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma by Richard A. Peterson, Bhavani Kashyap, Pamala A. Pawloski, Anna C. Forsberg, Leah R. Hanson

“…Genetic testing revealed no pathogenic mutation in the TP53 gene. Ultimately, treatment was unsuccessful and the patient succumbed to glioma and sarcoma within 2 years of initial diagnosis. …”
Get full text

Consumer Risk Perception of Food Contamination as an Influencer to Purchase Irradiated Ground Beef, Chicken, and Leafy Greens – United States, October 2022 by Michael Ablan, Tamara N. Crawford, Michelle Canning, Misha Robyn, Katherine E. Marshall

“…During October 7–9, 2022, we licensed data from a Porter Novelli Public Services survey (N = 1,008) to examine consumer risk perception of contamination of ground beef, chicken, and leafy greens with pathogens, and the potential influence risk perception has on purchasing irradiated versions of these foods. …”
Get full text

Biological properties of coronaviruses of farm, domestic animals and birds: comparative characterization of pathology they induce (review) by Kh. Z. Gaffarov, A. I. Yarullin, V. G. Gumerov, I. G. Karimullina

“…Members of the family Coronaviridae are characterized by the fact that they infect a wide range of animals and birds with expressed species-limited  pathogenicity.  One more coronavirus specificity involves their ability to simultaneously affect more than one organ. …”
Get full text

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast by Jiayao Zhang, Juan Li, Jiehong Huang, Xuerui Xiang, Ruoyu Li, Yun Zhai, Shuxian Lin, Weicai Liu

“…In this study, we established and analyzed the chronic unpredictable mild stress (CUMS) mice to investigate the miRNA-related pathogenic mechanism involved in psychological stress-induced osteoporosis. …”
Get full text

The relationship between kidney disease and mitochondria: a bibliometric study by Jueyi Mao, Cuifang Li, Feifeng Wu, Yang Wang, Junquan Zhu, Chuan Wen

“…We found that research in this field has shifted from disease-level studies to mechanism-based studies, with the most prominent disease being diabetic nephropathy and the most prominent pathogenic mechanism being related to mitochondrial ROS production.Conclusion The bibliometric analysis provided a comprehensive understanding of the progress of research on the role of mitochondria in kidney disease, enriching the review literature in this field.…”
Get full text

Development of nucleic acid-based vaccines against dengue and other mosquito-borne flaviviruses: the past, present, and future by Muhammad Bashir Bello, Ahlam Alsaadi, Asif Naeem, Sarah A. Almahboub, Mohammad Bosaeed, Mohammad Bosaeed, Safia S. Aljedani

“…The global prevalence of these viruses is largely driven by extensive international travels and ecological disruptions that create favorable conditions for the breeding of Aedes and Culex species, the mosquito vectors responsible for the spread of these pathogens. Currently, vaccines are available for only DENV, YFV, and JEV, but these face several challenges, including safety concerns, lengthy production processes, and logistical difficulties in distribution, especially in resource-limited regions, highlighting the urgent need for innovative vaccine approaches. …”
Get full text

Microbial and Inflammatory Salivary Biomarkers of Periodontal Diseases by Aram Mohammed Sha, Hayder Raad Abdulbaqi, Syed Saad Bin Qasim

“…In addition to periodontal pathogens, interest in salivary biomarkers of periodontal disease is increasing, and a number of biomarkers have the potential to be accurate indicators of disease and the effectiveness of therapy. …”
Get full text

Tinea manuum: a 5 year retrospective study of demographic data, clinical characteristics, and treatment outcomes by Panittra Suphatsathienkul, Pattriya Jirawattanadon, Lalita Matthapan, Waranyoo Prasong, Chatisa Panyawong, Akkarapong Plengpanich, Sumanas Bunyaratavej, Charussri Leeyaphan

“…Among 50 positive cultures, dermatophytes accounted for 86% and nondermatophytes for 14%, with Trichophyton rubrum (54%) and Trichophyton mentagrophytes complex (24%) being the most frequent pathogens. Systemic antifungal treatment was administered to 57% of patients, with a mycological cure rate of 56.4%. …”
Get full text

Epidemiology and Genetic Diversity of Colistin Nonsusceptible Nosocomial Acinetobacter baumannii Strains from Russia for 2013-2014 by Eugene A. Sheck, Mikhail V. Edelstein, Marina V. Sukhorukova, Natali V. Ivanchik, Elena Yu. Skleenova, Andrey V. Dekhnich, Ilya S. Azizov, Roman S. Kozlov

“…This article presents the epidemiological features and genetic diversity of colistin nonsusceptible A. baumannii strains collected as part of a national multicenter epidemiological study of the antibiotic resistance of pathogens of nosocomial infections (MARATHON), which was conducted in 2013-2014 in Russia. …”
Get full text

Changes Related to Age in Natural and Acquired Systemic Self-IgG Responses in Malaria by Romuald Dassé, Didier Lefranc, Sylvain Dubucquoi, Patricia Dussart, Virginie Dutoit-Lefevre, Boualem Sendid, François Sombo Mambo, Patrick Vermersch, Lionel Prin

“…Such distortion might be due to evolutionary processes leading to pathogenic/protective events.…”
Get full text

Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Case Report by Dane Wildner, Frank Boxberger, Axel Wein, Kerstin Wolff, Heinz Albrecht, Gudrun Männlein, Rolf Janka, Kerstin Amann, Jürgen Siebler, Werner Hohenberger, Markus F. Neurath, Richard Strauß

“…The histological workup revealed distinct granulomatous inflammation, but no microbial pathogens were to be found. Thereupon, a drug-induced reaction to chemotherapy was suspected and high-dose steroid treatment initiated. …”
Get full text

Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…These results enhance our understanding of the pathogenicity of different USUV strains and provide guidance for the use of low doses for inoculation in an Ifnar−/− animal model.…”
Get full text

NIR‐II emissive biohybrid nanovesicles as mild‐temperature photothermal antibiofilm agents against acute bacterial skin and skin‐structure infections by Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao

“…Abstract The emergence of antibiotic‐resistant bacteria poses a significant challenge to the prompt and appropriate treatment of pathogenic bacteria infections, such as acute bacterial skin and skin‐structure infections (ABSSSI), especially in the presence of biofilms. …”
Get full text

Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection by V. S. Priyadharshini, F. Ramírez-Jiménez, M. Molina-Macip, C. Renteria-Rosales, J. Santiago-Cruz, Paola Zarate-Segura, E. Lara-Padilla, Luis M. Teran

“…Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. …”
Get full text

Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70 by Małgorzata Kowalska, Marzena Tylicka, Olga Martyna Koper-Lenkiewicz, Joanna Kamińska, Justyna Dorf, Ewa Matuszczak

“…The aim of this study was to explore the role of HSP-70, MMP-3, MMP-17 and IL-8 in possible pathogenic pathways connected with cryptorchidism. Cryptorchid patients with high scrotal and inguinal canal localization were included. …”
Get full text

Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity‐Switching, Self‐Immobilizing, Near‐Infrared Fluorogenic β‐Lactamase Probe Enriched within Bacteria... by Fangfang Chen, Yuyao Li, Yan Peng, Yifan Zhu, Gao He, Zhengwei Zhang, Hexin Xie

“…The discovery of effective therapies against antibiotic‐resistant pathogens has become an urgent need, necessitating innovative approaches to accelerate the identification and development of novel antibacterial agents. …”
Get full text