Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia by Huang-Pin Wu, Chien-Ming Chu, Chun-Yao Lin, Chung-Chieh Yu, Chung-Ching Hua, Teng-Jen Yu, Yu-Chih Liu

“…The most frequently isolated pathogens were Pseudomonas aeruginosa, S. aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. …”
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NF-κB Signaling in the Brain of Autistic Subjects by Mazhar Malik, Zujaja Tauqeer, Ashfaq M. Sheikh, Guang Wen, Amenah Nagori, Kun Yang, W. Ted Brown, Xiaohong Li

“…The NF-κB activation is also determined in the brain of BTBR mice, which is a promising animal model for study of pathogenic mechanisms responsible for autism. Our results showed that the level of IKKα kinase, which phosphorylates the inhibitory subunit IκBα, is significantly increased in the cerebellum of autistic subjects. …”
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Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes by Samira Mukhtar Buzinin, Aied Mohammed Alabsi, Alexander Tong Boon Tan, Vui King Vincent-Chong, Dasan Swaminathan

“…Microbiological studies indicated that there were significant reductions in the levels of the tested pathogens in both groups. The results of our study were similar to the findings of several other studies that had been done previously.…”
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Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer by Rizwan Romee, Jeffrey W. Leong, Todd A. Fehniger

“…Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. …”
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Escherichia coli growing under antimicrobial gallium nitrate stress reveals new processes of tolerance and toxicity by Daniel A. Salazar-Alemán, Raymond J. Turner

“…Gallium nitrate has shown promising efficacy against several pathogens. Although its main toxicity mechanisms have focused on oxidative stress and its “trojan horse” iron mimetic strategy, there are still many knowledge gaps in the full-systems response elicited to counteract its toxic effects, especially in non-acute toxicity models that evaluate longer exposure times. …”
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Detection of Staphylococcal Enterotoxins A and E and Methicillin Resistance in Staphylococcus aureus Strains From Moroccan Broiler Chicken Meat by Sabrine Nacer, Saâdia Nassik, Fatima Zahra El Ftouhy, Sophia Derqaoui, Mohamed Mouahid, Mustapha Lkhider

“…Foods of animal origin, in particular chicken meat, are considered to be potential vectors of pathogenic bacteria, particularly Staphylococcus aureus. …”
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Young Woman with Unexplained Neutropenia and Neutrophils with Bilobed Nuclei: Marrow Findings by Martin Barnes, Victoria Shklar, Dipen Patel, Harry Staszewski

“…Germline testing in the LBR gene revealed a heterozygous pathogenic mutation, namely, the PR57837.17 variant, confirming the diagnosis of hereditary disease. …”
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Novel IL2RG gene mutation causing primary combined immunodeficiency disease: A case report and literature review by Fang Cao, Yingyu Shi, Fang Deng, Yu Yan

“…Whole exome sequencing did not identify any genetic variants highly associated with and definitively pathogenic for bronchiectasis but detected a compound heterozygous missense mutation c.420A>T (p.R140S) in the IL2RG gene, linked to primary combined immunodeficiency (CID), a clinical phenotype rarely reported in China due to this gene mutation. …”
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Functional Development of the Human Gastrointestinal Tract: Hormone- and Growth Factor-Mediated Regulatory Mechanisms by Daniel Ménard

“…These new cells lines could serve important applications in the study of pathogenic action and epithelial regeneration.…”
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Elucidating genetic intersections: Co-differentially expressed genes in myasthenia gravis and idiopathic inflammatory myopathies and their role in comorbid pathogenesis by Wenqu Yang, Feng Liang

“…Objective: This study aims to identify common differentially expressed genes (co-DEGs) between MG and IIM to elucidate shared pathogenic pathways and potential therapeutic targets. …”
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Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…Although mutations and variations of several genes have been identified to be involved in Alzheimer's disease (AD), the efforts towards understanding the pathogenic mechanisms of the disease still have a long journey to go. …”
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Determination of extended spectrum beta-lactamase producing escherichia coli strains in chicken meat samples by Güzin İplikçioğlu Çil, Görkem Cengiz, Buse Arslan, Ufuk Tansel Şireli

“…Although foods are regularly examined in the context of pathogenic bacteria, bacteria producing GSBL are not covered by this. …”
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Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders by Mani B. Subramani, Krishnan Mahalakshmi, Bharathy Jaya, Sankar Leena Sankari, Venkatesan N. Kumar

“…Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans). …”
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Identification of a novel papillomavirus in oral swabs from giant pandas (Ailuropoda melanoleuca) by Yi Zhao, Min Zhao, Wen Zhang

“…The discovery provides valuable insights into the viral diversity in giant pandas and highlights the need for continued surveillance of wildlife pathogens. Future studies should explore the potential role of AmPV5 in the health and disease ecology of this endangered species.…”
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Epidemiology of subclinical mastitis in family size dairy farms in hatay region by Yaşar Ergün, Özkan Aslantaş, Zafer Cantekin

“…A total of 262 milk samples from 115 (71.9 %) mastitic cows were investigated for aerobic pathogenic microorganism. From this 262 milk samples, 231 aerobic microorganisms were isolated and identified in 200 milk samples. …”
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Dysfunction Characteristics of Knee Osteoarthritis with the Conception of"Muscles and Bones, Arthralgia and Flaccidity, Asthenia and Sthenia, Dynamic and Static, Hardness and Softn... by Jiemei GUO, Peng CHEN, Tangyan CAI, Yan XIAO, Xiao MAO, Youxin SU

“…At different KOA stages, the comorbidity of tendons with bones is the basic pathogenic characteristic of KOA dysfunction, which focuses on disease location and extends throughout the KOA process; coexistence of arthralgia and flaccidity, and mixture of asthenia with sthenia emphasize the basic characteristic of KOA dysfunction; imbalance between dynamic and static statuses is the main factor of KOA relapse and aggravation, which focuses on KOA etiology; disorder between hardness and softness emphasizes both syndrome and etiology, indicating the disorder between bones and tendons. …”
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Comparison of the antibacterial efficacy of 810 nm diode laser and photodynamic therapy in reducing microbial flora in patients with peri-implant mucositis – An in vivo study by Poonam Siwach, Reshu Sanan, Abhishek Nagpal, Omkar Krishna Shetty, Amit Bhardwaj, Mukesh Sharma

“…Conclusion: Within the limitations of the study, it can be concluded that there is a definitive reduction in pathogenic bacteria with both interventions and PDT offers clinically visible benefits in the treatment of peri-implant mucositis.…”
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Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis by Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson

“…Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. In this study, we investigate the role of IL-17 and Type 17 immune signaling components during IAPA.MethodsWild-type mice were challenged with influenza A H1N1 (flu) and then exposed to Aspergillus fumigatus ATCC42202 resting conidia on day 6 post-influenza infection, followed by the quantification of cytokines and chemokines at 48 h post-fungal infection.Results and discussionThe gene and protein expression levels revealed that IL-17 and Type 17 immune cytokines and antimicrobial peptides are downregulated during IAPA compared to mice singularly infected solely with A. fumigatus. …”
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The Role of IL-33 in Gut Mucosal Inflammation by Luca Pastorelli, Carlo De Salvo, Maurizio Vecchi, Theresa T. Pizarro

“…Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective. Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other. …”
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Microbial Fermentation in Food and Beverage Industries: Innovations, Challenges, and Opportunities by Mallari Praveen, Simone Brogi

“…Although there are risks of contamination and spoilage by pathogenic and undesirable microorganisms, advanced technologies and proper control procedures can mitigate these risks. …”
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