Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) by Shumyila Nasir, Muhammad Sufyan Vohra, Danish Gul, Umm E Swaiba, Maira Aleem, Khalid Mehmood, Saadia Andleeb

“…The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), the chief etiological agent for a range of refractory infections, has rendered all β-lactams ineffective against it. …”
Get full text

Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy by Runxiu Wei, Gaojie Li, Yuying Huang, Linjing Mi, Jiamin Wu, Huan Huang, Na Yin, Yuling Chen, Qiang Yang, Wenjun Zhang, Bingzhi Sun, Ran Sun, Ling Guo, Min Feng

“…In light of their precise elimination of bacterial colonization and modulation of the infectious microenvironment, the H-Janus antibacterial packs show promising therapeutic potential for preventing the recurrence of periodontal pathogens following scaling and root planning.…”
Get full text

Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1-related Parkinson’s disease by Peng Liu, Fan Zhang, Xinhui Chen, Xiaosheng Zheng, Miao Chen, Zhiru Lin, Shuqi Chen, Lebo Wang, Xinchen Wang, Nan Jin, Chenxin Ying, Fei Xie, Bo Wang, Sheng Wu, Zhidong Cen, Wei Luo

“…RNA foci were detected in the (AGGGG)exp-expressed HEK293T cell line as well as (AAGGG)exp and (ACAGG)exp, supporting (AGGGG)exp as a novel pathogenic repeat motif. This work revealed complex genotypes with novel repeat configuration of (AGGGG)exp and possible somatic (AATGG)exp insertion in RFC1-related PD.…”
Get full text

Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…Myeloid C-type lectin receptors (CLRs) constitute a large family of transmembrane carbohydrate-binding receptors that recognize pathogens as well as endogenous glycoproteins. Several lines of evidence demonstrate that some CLRs can inhibit the immune response. …”
Get full text

Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups by Ali Yaseen, Jaleel Samanje, Qahtan Adnan Rasheed, Rafah Sabah Barrak, Afraa Brahim

“…Methicillin-resistant Staphylococcus aureus (MRSA) is among the most essential multidrug-resistant bacterial pathogens. The study aimed to determine the prevalence of (MRSA) from different clinical samples to emphasise the suitable treatment. …”
Get full text

Antibiotic resistance gene occurrence in poultry farms in northeast Brazil by Henrique Francisco de Almeida, Paulo Ricardo Conceição Marques Trindade, César Roberto Viana Teixeira, Claudson Oliveira Brito, Silvio Santana Dolabella, Sona Jain, Maíra Pompeu Martins, Ana Andréa Barbosa

“… The misuse of antibiotics in food-producing animal farming practices exerts selective pressure on bacterial strains, intensifying the spread of pathogenic and commensal bacteria carrying antibiotic resistance genes (ARGs). …”
Get full text

Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents by Johana Zúñiga-Miranda, Rebeca González-Pastor, Saskya E. Carrera-Pacheco, Cristina Rodríguez-Pólit, Carlos Barba-Ostria, Antonio Machado, Linda P. Guamán, Christian D. Alcivar-León, Jorge Heredia-Moya

“…In this studio, a series of Schiff bases 3a–h derived from 4-aminoantipyrine and substituted cinnamaldehydes were evaluated in vitro against liver (HepG2) and thyroid (THJ29T) cancer cells, Gram-positive and Gram-negative multidrug-resistant bacteria, and biofilm-forming pathogens. Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. …”
Get full text

Analysis of microorganisms and antibiotic resistance in medical instruments in the central sterile supply department (CSSD) of hospitals before and after sterilization by Hapsari Woro, Sajidan, Suranto, Hikmayani Nur Hafidha

“…Sterilization is essential in preventing the spread of pathogenic bacteria and antibiotic resistance in hospital settings. …”
Get full text

A single entomopathogenic nematode infection assay for Drosophila melanogaster larvae by Sreeradha Mallick, Eric Kenney, Jacob Rashap, Ioannis Eleftherianos

“…While previous studies have described successful infection of D. melanogaster larvae with a standard amount of 100 IJs, the pathogenicity of a single IJ nematode towards insects remains poorly understood. …”
Get full text

Characterization of fermentation liquid from mangrove leaves Avicennia marina and its inhibitory potential for bacterium causing ice-ice disease by Samsu Adi Rahman, Sukenda, Widanarni, Alimuddin, Julie Ekasari

“…This study aimed to identify bacteria and the compounds in fermentation liquid of mangrove leaves A. marina and measured their inhibitory capacity against pathogenic bacteria Stenotrophomonas maltophilia which causes ice-ice disease in seaweed. …”
Get full text

Universal antibacterial and anti-inflammatory treatment using chitosan-prussian blue nanozyme by Jian Wang, Jiayi Wang, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia, Xueliang Liu, Yu Yang

“…Bacterial infections are a growing global public health problem, exacerbated by the widespread and often inappropriate use of antibiotics, leading to the emergence of non-antibiotic pathogens. Herein, we synthesized a chitosan-Prussian blue nanozyme (CS@PB), a non-antibiotic agent, for universal antibacterial and anti-inflammatory treatment of bacterial infections. …”
Get full text

Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case by Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Maria Reyes-Batlle, Carmen M. Martín-Navarro, Jacob Lorenzo-Morales

“…The phylogenetical analysis as well as the sequencing of the acquired amplified product for the DF3 region of the amoebae isolate confirmed that it belongs to genotype T3, which includes other pathogenic amoebae; besides the activity of two drugs currently used against Acanthamoeba was tested on A. griffini.…”
Get full text

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway by Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung

“…Abstract Background Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). …”
Get full text

Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccina... by Caroline Kuhn, Holm Zerbe, Hans-Joachim Schuberth, Anke Römer, Debby Kraatz-van Egmond, Claudia Wesenauer, Martina Resch, Alexander Stoll, Yury Zablotski

“…Prepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. …”
Get full text

EVALUATION OF REFILLABLE DRINKING WATER QUALITY BASED ON MPN COLIFORM AND ESCHERICHIA COLI INSESETAN VILLAGE, SOUTH DENPASAR, BALI by Pande Nyoman Tri Saguna Wyasena, Ni Luh Gede Sudaryati, I Putu Sudiartawan, I Made Dwi Mertha Adnyana

“…However, the quality of refilled drinking water has been tainted with pathogens that can cause health problems. Purpose: To assess the quality of replenished drinking water in Sesetan Village using Most Probable Number (MPN) Coliform and Escherichia coli as indicators. …”
Get full text

Comparison of Biofilm and Attachment Mechanisms of a Phytopathological and Clinical Isolate of Klebsiella pneumoniae Subsp. pneumoniae by Adriana Marcia Nicolau Korres, Gloria Maria de Farias V. Aquije, David S. Buss, Jose Aires Ventura, Patricia Machado Bueno Fernandes, Antonio Alberto Ribeiro Fernandes

“…It is almost impossible to prevent the contact of clinically pathogenic bacteria with food crops, and if they can persist there, they can reenter the human food chain and cause disease. …”
Get full text

Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis by Célia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Mario Fernandez Comaduran, Morgane Verbrugghe, Jia Ming Stella Xu, Sandra Minotti, James Lynch, Jeetayu Biswas, Tad Wu, Heather D. Durham, Gene W. Yeo, Maria Vera

“…Stress-mediated HSPA8 mRNA localization to the dendrites is impaired by depleting fused in sarcoma—an amyotrophic lateral sclerosis-related protein—in cultured spinal cord mouse motor neurons or by expressing a pathogenic variant of heterogenous nuclear ribonucleoprotein A2/B1 in neurons derived from human induced pluripotent stem cells. …”
Get full text

Specific features of the study and maintenance of a potato collection threatened by viruses and virus-like diseases by E. V. Truskinov, M. N. Sitnikov

“…Among the infected plant material, accessions with a latent virus infection, manifesting tolerance to the pathogens, have constantly been observed. The conventional point-based principle of scoring field resistance of potato cultivars and hybrids to viruses requires a significant revision. …”
Get full text

Human adaptation and diversification in the Microsporum canis complex by Xin Zhou, Sarah A. Ahmed, Chao Tang, Maria Eduarda Grisolia, José Francisco Ghignatti Warth, Kristen Webster, Andrea Peano, Silke Uhrlass, Claudia Cafarchia, Marie Pierre Hayette, Rosalie Sacheli, Tadeja Matos, Yingqian Kang, G. Sybren de Hoog, Peiying Feng

“…These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. …”
Get full text

Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female by Kathryn E. Kalata, Christina Osborne, Amy Willis, Kacey Navarro, Laura Z. Fenton, Christiana Smith

“…This highlights the importance of maintaining a broad differential for opportunistic infections, especially among those who have spent a significant amount of time in a country where unusual pathogens may be more common. This case also considers the utility of antigen testing as a sensitive diagnostic test in immunocompromised patients.…”
Get full text