Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis by Christopher R. Shaler, Carly Horvath, Rocky Lai, Zhou Xing

“…When compared with other intracellular bacterial lung pathogens, such as Legionella pneumophila, or even closely related mycobacterial species such as M. smegmatis, this delay is astonishing. …”
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Synthesis, Spectroscopic Characterisation, and Biopotential and DNA Cleavage Applications of Mixed Ligand 4-N,N-Dimethylaminopyridine Metal Complexes by C. Surendra Dilip, K. Manikandan, D. Rajalaxmi (a) Subahashini, R. Thiruneelakandan

“…The antimicrobial studies against various pathogenic bacterial and fungal serums insist on that the enhanced potential of the complexes over their ligand and their biopotential properties increases with concentration. …”
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Coffea canephora Peptides in Combinatorial Treatment with Fluconazole: Antimicrobial Activity against Phytopathogenic Fungus by Gabriela C. V. Bard, Gabriel B. Taveira, Thaynã A. M. Souza, Érica O. Mello, Sávio B. Souza, Alessandro C. Ramos, André O. Carvalho, Lídia S. Pereira, Umberto Zottich, Rosana Rodrigues, Valdirene M. Gomes

“…The objective of the present study was to evaluate the antimicrobial activity of the Cc-LTP2 and Cc-GRP peptides isolated from Coffea canephora seeds and their possible synergistic activity with the azole drug fluconazole and characterize their mechanisms of action on cells of pathogenic fungi. Cc-LTP2 and Cc-GRP alone or in combination with 20 µg/mL of fluconazole were evaluated for their antimicrobial activity on the fungus Fusarium solani, and the effects of these peptides on the permeability of membranes and the induction of oxidative stress were determined. …”
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Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases by Themis Thoudam, Jae-Han Jeon, Chae-Myeong Ha, In-Kyu Lee

“…MAM provides an excellent platform for numerous signaling pathways; among them, inflammatory signaling pathways associated with MAM play a critical role in cellular defense during pathogenic infections and metabolic disorders. However, induction of MAM causes deleterious effects by amplifying mitochondrial reactive oxygen species generation through increased calcium transfer from the ER to mitochondria, thereby causing mitochondrial damage and release of mitochondrial components into the cytosol as damage-associated molecular patterns (DAMPs). …”
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A new crustin-like gene from the redclaw crayfish Cherax quadricarinatus and its response to decapod iridescent virus 1 (DIV1) challenge by Xiaoying Hang, Jianbo Zheng, Fei Li

“…Crustin, a widely-studied antimicrobial peptides (AMPs), has been proven to be involved in mediating innate immune responses against intruding pathogens. In this study, a novel crustin-like gene, Cqcarc1, was characterized from the redclaw crayfish Cherax quadricarinatus. …”
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Traffic Control of Bacteria-Derived Molecules: A New System of Host-Bacterial Crosstalk by Hiroaki Konishi, Mikihiro Fujiya, Yutaka Kohgo

“…Virulent microorganisms, such as pathogenic bacteria and viruses, are recognized by pattern recognition receptors (PRRs), including toll-like receptors (TLRs) and nucleotide-binding oligomerization-domain proteins (NODs), and induce inflammatory responses in mammalian hosts. …”
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Pisonia Alba Assisted Synthesis of Nanosilver for Wound Healing Activity by Suba Kannaiyan, D. Easwaramoorthi, Karthik Kannan, Andal Gopal, R. Lakshmipathy, Khadijah Mohammedsaleh Katubi, Nayef S. Almuaikel, Ivan Leandro Rodriguez Rico

“…Antibacterial and antibiofilm potential of synthesized silver nanoparticles against pathogenic organisms Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria were investigated. …”
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BANNMDA: a computational model for predicting potential microbe–drug associations based on bilinear attention networks and nuclear norm minimization by Mingmin Liang, Xianzhi Liu, Juncai Li, Qijia Chen, Bin Zeng, Zhong Wang, Jing Li, Lei Wang

“…We conducted case studies on well-known drugs such as the Amoxicillin and Ceftazidime, as well as on pathogens such as Bacillus cereus and Influenza A virus, to further evaluate the efficacy of BANNMDA, and experimental outcomes showed that there were 9 out of the top 10 predicted drugs, along with 8 and 9 out of the top 10 predicted microbes having been corroborated by relevant literatures. …”
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Microbial Contamination of Nebulizers in Patients With Cystic Fibrosis by Cansu Yilmaz Yegit, Pinar Ergenekon, Nurcan Duman, Hakan Mursaloglu, Muruvvet Cenk, Burcu Suzer Uzunoglu, Gamze Tastan, Yasemin Gokdemir, Ela Erdem Eralp, Aysegul Karahasan Yagci, Fazilet Karakoc, Bulent Karadag

“…Conclusion: The nebulizer contamination rate with pathogenic microorganisms is low in the present study. …”
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Molecular Identification of Mycobacterium Species of Public Health and Veterinary Importance from Cattle in the South State of México by Adrian Zaragoza Bastida, Nallely Rivero Pérez, Benjamín Valladares Carranza, Keila Isaac-Olivé, Pablo Moreno Pérez, Horacio Sandoval Trujillo, Ninfa Ramírez Durán

“…Except M. parafortuitum, the other species identified are of public health and veterinary concern because they are pathogenic to humans, especially those with underlying medical conditions.…”
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Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. …”
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A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus by Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha

“…Overall, our findings suggest that overflow metabolism offers S. aureus distinct bioenergetic advantages over a thermodynamically constrained TCA cycle, potentially supporting its commensal–pathogenic lifestyle.…”
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Absence of infection by Trichinella spp. (Nematoda: Trichinellidae) in free-living wild carnivores in Brazil by Lívia de Oliveira Andrade, Patricia Parreira Perin, Carmen Andrea Arias-Pacheco, Camilla de Souza Amorim, Fernanda Lefort, Fernanda Mara Aragão Macedo Pereira, Lauro Leite Soares-Neto, Antonio de Pádua Bordignon Fernandes, Wilson Junior Oliveira, Ricardo Shoiti Ichikawa, André Luiz Mota da Costa, Paulo Henrique Peira Ruffino, Karin Werther, Estevam Guilherme Lux Hoppe

“…BackgroundNematodes of the genus Trichinella are foodborne zoonotic pathogens that are widespread globally. These parasites have two epidemiological cycles, domestic and sylvatic, with the latter having wild carnivores as the main reservoirs of the parasite. …”
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Diseases impact the performance of maize hybrids in southern Minas Gerais by Guilherme Vieira Pimentel, Luiz Daniel Rodrigues da Silva, Natalia Costa, Amanda Santana, Elisabete da Cruz Silva Watanabe, Silvino Guimarães Moreira

“…The evaluated traits were: severity (%) of foliar and ear diseases, incidence (%) of pathogens in grains, plant and ear height, yield, weight of 100 grains and final stand. …”
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The immunoglobulin of yolk and cerium oxide-based fibrous poly(L-lactide-co-glycolide)/gelatin dressings enable skin regeneration in an infectious wound model by Xinyuan Zhao, Changwen Weng, Hao Feng, Muhammad Shafiq, Xinyi Wang, Lei Liu, Lu Han, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Zhengchao Yuan, Xiumei Mo, Yanbiao Wang

“…The immunoglobulin of yolk (IgY) exhibits immunotherapeutic potential for the potential treatment of antimicrobial-resistant pathogens, while cerium oxide nanoparticles (CeO2 NPs) could scavenge superoxide dismutase (SOD) and inflammation. …”
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Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy by Ting Gong, Boon Chin Heng, Edward Chin Man Lo, Chengfei Zhang

“…Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. …”
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Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies by Aurora Reiss, Mariana Carmen Chifiriuc, Emilia Amzoiu, Cezar Ionuţ Spînu

“…All the synthesized complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. …”
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SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in Streptococcus pneumoniae D39 by Ye Tao, Li Lei, Shuhui Wang, Xuemei Zhang, Yibing Yin, Yuqiang Zheng

“…Streptococcus pneumoniae capsular polysaccharide (CPS) is a crucial virulence factor for this pathogenic bacterium and is partially under transcriptional control. …”
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C-Reactive Protein in Human Atherogenesis: Facts and Fiction by Oliver Zimmermann, Kefei Li, Myron Zaczkiewicz, Matthias Graf, Zhongmin Liu, Jan Torzewski

“…Whereas initial experimental studies suggested a pathogenic role for CRP in atherogenesis, more recent genetic data from Mendelian randomization trials failed to provide evidence for a causative role of CRP in cardiovascular disease. …”
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Phages as potential life-saving therapeutic option in the treatment of multidrug-resistant urinary tract infections by Beata Zalewska-Piątek, Michalina Nagórka

“…Phage therapy (PT) has emerged as a promising alternative due to its specificity, safety and efficacy against multidrug-resistant (MDR) pathogens causing infectious diseases. PT demonstrates significant potential in treating chronic and recurrent UTIs, also including catheter-associated infection by reducing bacterial biofilms, delaying catheter blockage, and enhancing antibiotic efficacy when used in combination. …”
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