Seroprevalence of Toxoplasma gondii in Wild Rats (Rattus rattus) in Northern Iran by Seyed Abdollah Hosseini, Saeid Abediankenari, Afsaneh Amouei, Shahabeddin Sarvi, Mehdi Sharif, Fatemeh Rezaei, Ahmad Daryani

“…Rodents are considered as reservoir hosts for various pathogens (such as Toxoplasma gondii) and have been revealed to play an important role in the spread of several infectious diseases to humans and other animals. …”
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A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease by Patricia Gómez-Suaga, Elena Fdez, Marian Blanca Ramírez, Sabine Hilfiker

“…G2019S, the most prominent pathogenic mutation, maps to the kinase domain and enhances enzymatic activity of LRRK2, which in turn seems to correlate with cytotoxicity. …”
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Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes by Wanyi Huang, Wei He, Yue Huang, Yongping Tang, Ming Chen, Lianbei Sun, Zuwei Yang, Tianyi Hou, Huimin Liu, Haoyu Chen, Tianpeng Wang, Na Li, Yaqiong Guo, Lihua Xiao, Yaoyu Feng

“…Deletion of the MEDLE genes significantly reduces the growth and pathogenicity of a virulent strain in mice. Co-infection of two fluorescence-tagged C. hominis subtypes produces bicolored oocysts, supporting the conclusion that mixed subtype infections can lead to genetic recombination. …”
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Study of the Effect of Nutrient Environment on the Biological Characteristics of Fusarium solani Clinical Corneal Isolates by Dalan Jing, Yingyu Li, Ziyuan Liu, Chen Huang, Pei Zhang, Wei Wang

“…The biological characteristics of Fusarium solani clinical corneal isolates growing in different nutritional conditions in vitro were studied in order to find out the key point of pathogenicity. Methods. Five kinds of media with different glucose and nitrogen concentrations were prepared as the liquid and solid forms. …”
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Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens by Ricardo Vieira, Maria José Simões, Susana Carmona, Conceição Egas, Carlos Faro, Américo Figueiredo

“…We found the mutation in 3 primary melanomas and in 2 melanocytic nevi, corresponding to a relatively low prevalence (3.7% and 7.1%, resp.). The pathogenic role of DLEC1 215N mutation is unclear. However, since the mutation has not been previously described in general population, its involvement in nevogenesis and melanoma progression remains a possibility to be clarified in future studies.…”
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Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health by Pedro Pablo Martínez-Rojas, Verónica Monroy-Martínez, Blanca H. Ruiz-Ordaz

“…The available evidence suggests that extracellular vesicles mediate diverse functions between hosts, constituting novel effectors for understanding the pathogenic mechanisms of flaviviral diseases.…”
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BV/ODV-E26 is a conserved baculoviral inhibitory factor for optimizing viral virulence in lepidopteran hosts by Hiroyuki Hikida, Ryuhei Kokusho, Susumu Katsuma

“…In this study, we found that the overexpression of BmNPV bv/odv-e26 delayed viral infection in cultured cells and decreased pathogenicity in B. mori larvae. We also discovered that homologs of bv/odv-e26 are conserved more widely in alphabaculoviruses than previously thought. …”
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Macrophages in Tumor Microenvironments and the Progression of Tumors by Ning-Bo Hao, Mu-Han Lü, Ya-Han Fan, Ya-Ling Cao, Zhi-Ren Zhang, Shi-Ming Yang

“…Macrophages are widely distributed innate immune cells that play indispensable roles in the innate and adaptive immune response to pathogens and in-tissue homeostasis. Macrophages can be activated by a variety of stimuli and polarized to functionally different phenotypes. …”
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Molecular Prevalence and Identification of Ehrlichia canis and Anaplasma platys from Dogs in Nay Pyi Taw Area, Myanmar by Myint Myint Hmoon, Lat Lat Htun, May June Thu, Hla Myet Chel, Yu Nandi Thaw, Shwe Yee Win, Nyein Chan Soe, Yadanar Khaing, Su Su Thein, Saw Bawm

“…In Myanmar, there is limited information concerning tick-borne pathogens, Ehrlichia and Anaplasma spp., as well as genetic characterization of these species. …”
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Enhanced Antibacterial Activity of Hydrophobic Modified Lysozyme Against Gram-Negative Bacteria Without Accumulated Resistance by Zhenhui Li, Song Lin, Mei Zhu, Xiaoman Liu, Xin Huang

“…We investigated its antibacterial mechanism against Gram-negative bacteria and showed that HML could be used to treat pathogenic bacteria without obvious accumulated resistance appearance, which is a great advantage over commercial antibiotics. …”
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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo by Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis

“…In this study, we used Caenorhabditis elegans to screen for E3 ubiquitin ligases regulating the activity of TFEB’s homolog, HLH-30, upon pathogenic infection. We identified WWP-1 as a regulator of HLH-30-dependent immune response controlling HLH-30 stability to mediate host defense in vivo. …”
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The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers by Shanjun Chen, Chong Wang, Yanan Liu, Zhigang Zhou, Linglin Fu, Yanbo Wang

“…Microbiota analysis revealed that EQ resulted in different composition and lower diversity of the flesh microbiota and upregulated the proportion of potential pathogens. EQ also changed the flesh metabolome, decreasing beneficial metabolites and increasing potential harmful components. …”
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Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease by Hongling Zhu, Y. Terry Lee, Colleen Byrnes, Jabili Angina, Danielle A. Springer, Galina Tuymetova, Mari Kono, Cynthia J. Tifft, Richard L. Proia

“…Sandhoff disease, a lysosomal storage disorder, is caused by pathogenic variants in the HEXB gene, resulting in the loss of β-hexosaminidase activity and accumulation of sphingolipids including GM2 ganglioside. …”
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Enteric coating of granules containing the probiotic Lactobacillus acidophilus by Pyar Hassan, Peh Kok-Khiang

“…In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestine…”
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Ofatumumab successfully treats myelin oligodendrocyte glycoprotein antibody-associated disease accompanied by Epstein-Barr viral infection: a case series by Chen Min, Bi Zhuajin, Liu Peidong, Li Ruoyu, Liu Ju, Liu Hongbo

“…Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) caused by pathogenic immunoglobulin G antibodies to myelin oligodendrocyte glycoprotein is a rare demyelinating disease of the central nerve system (CNS). …”
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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution by Yuxin Liu, Jinhong Li, Qicai Liu

“…The inactivation of CMAH protected our ancestors from some pathogens and reduced the level of N-glycolylneuraminic acid (Neu5Gc) in brain tissue. …”
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The Impact of Migraine on Posterior Ocular Structures by Süleyman Demircan, Mustafa Ataş, Sevgi Arık Yüksel, Melek D. Ulusoy, İsa Yuvacı, Hasan Basri Arifoğlu, Burhan Başkan, Gökmen Zararsız

“…These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.…”
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Exploring Potential of a Remote Plasma Electrolysis System (RPES) for Fruit Surface Sterilization by Thana Phuthidhorn, Jaikua Mathin, Maitip Jakkrawut, Ungwiwatkul Sunisa, Prasertboonyai Kanyarak, Rueangwong Athitta, Promsart Woranika

“…These findings demonstrate RPES’s effectiveness in inactivating surface pathogens on fruits, highlighting its potential for broader applications in fruit sterilization.…”
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The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? by Balahan Makay, Ozer Makay, Cigdem Yenisey, Gokhan Icoz, Gokhan Ozgen, Erbil Unsal, Mahir Akyildiz, Enis Yetkin

“…Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. …”
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Plant Adaptability to Improved Dredged Sediment by Shoulong Zhang, Rixiong Mo, Haorong Shi, Yuanzhen Li, Yaoyao Zhou, Chenhao Wang, Guanlong Yu

“…The main dominant fungi in the improved soil (IS1) were <i>Tausonia</i>, <i>Trichoderma</i>, and <i>Cystoflobasidium</i>, which promote soil nutrient activation and antagonize pathogenic bacteria, making the environment more conducive to plant growth. …”
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