Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss by Fengguo Zhang, Lei Xu, Yun Xiao, Jianfeng Li, Xiaohui Bai, Haibo Wang

“…They were concluded to be pathogenic mutations by phylogenetic analysis and structure modeling. …”
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Functional and Antimicrobial Properties of Propolis from Different Areas of Romania by Gianluca Albanese, Alexandru Ioan Giurgiu, Otilia Bobiș, Adriana Cristina Urcan, Sara Botezan, Victorița Bonta, Tudor Nicolas Ternar, Claudia Pașca, Massimo Iorizzo, Antonio De Cristofaro, Emilio Caprio, Daniel Severus Dezmirean

“…This substance plays a crucial role in the hive’s defence against a range of pathogenic agents, maintaining a consistent internal temperature and aseptic environment for the bee colony. …”
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Changes in glycosphingolipid levels in plasma and cerebrospinal fluid of individuals with Lysosomal Free Sialic Acid Storage Disorder by Marya S. Sabir, Lynne Wolfe, David R. Adams, Carla Ciccone, Forbes D. Porter, William A. Gahl, Marjan Huizing, Frances M. Platt, May Christine V. Malicdan

“…Lysosomal free sialic acid storage disorder (FSASD) is a rare, multisystem disease caused by biallelic pathogenic variants in SLC17A5, encoding the lysosomal transmembrane sialic acid exporter, sialin. …”
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Stray dogs as carriers of E. coli resistant strains for the retracted and re-emerged antibiotic colistin, based on the mcr-1 gene presence by Ioannis Tsakmakidis, Anastasia Parisi, Dimitrios K. Papadopoulos, Maria V. Alvanou, Konstantinos V. Papageorgiou, Evanthia Petridou, Ioannis A. Giantsis

“…Companion animals could have a role in human infection by pathogenic and resistant E. coli strains as they share the same environment and are in close contact with humans. …”
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Carbon nanodots from used green tea biochar: antibacterial applications and antibiofilm carbon coatings by E. Elsa Sharon, Jae-Wook Oh, Judy Gopal

“…The antibacterial activity was tested against pathogenic coliforms as well as oral bacteria. The results indicated that the indigenously prepared carbon nanodots exhibited significant antibacterial activity. …”
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Exploring RNA modifications in infectious non-coding circular RNAs by Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco di Serio, Beatriz Navarro, Hana Cahova

“…Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA. …”
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Research on Pork Jerky Obtained Through Fermentation with Pediococcus acidilactici by Zhao Xingxiu, Zhang Jing, Ming Hongmei, Zou Wei, Wang Yang, Zhao Changqing, Mu Shengdong, Zhang Hao, Qiu Lin

“…Furthermore, in the fermented pork jerky, the content of three acids (18.552%) was high, which lowered the pH of the pork jerky and inhibited growth of pathogens. Moreover, some new compounds produced, including 3-hydroxy-2-butanone (49.095%), 2,3-butanediol (2.790%), 2-ethyl-1-hexanol (2.400%), oxalic acid isobutyl hexyl ester (2.280%), phenylethyl alcohol (0.953%), and eucalyptol (0.659%), contributed to the flavour of pork jerky. …”
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Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites by Zeng Zhang, Yajing Fang, Yangli He, Mohamed A. Farag, Min Zeng, Yukai Sun, Siqi Peng, Shuaiming Jiang, Xian Zhang, Kaining Chen, Meng Xu, Zhe Han, Jiachao Zhang

“…Probio-M8 significantly improved muscle function in aged mice and enhanced physical performance in sarcopenia patients. It reduced pathogenic gut species and increased beneficial metabolites such as indole-3-lactic acid, acetoacetic acid, and creatine. …”
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Case report: VEXAS syndrome: first documented cases in Latin America by Carolina Ottati, Inés Gervaz, Inés Gervaz, Martín Yandian, Martín Yandian, Matilde Boada, Matilde Boada, Gabriela Vidal-Senmache, Percy Ortiz-Guerra, Ana I. Catalán, Patricia Kutscher, Diego Lopez, Lilian Diaz, Sofia Grille, Sofia Grille

“…All cases were confirmed via genetic testing, revealing pathogenic UBA1 mutations alongside other genetic variants commonly linked with myeloid neoplasms.DiscussionThese findings underscore the importance of considering VEXAS syndrome in patients with unexplained inflammatory and hematologic symptoms. …”
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Recent advances in nanomaterials and their mechanisms for infected wounds management by Jianping Zhu, Fan Xia, Shuaifei Wang, Yan Guan, Fuqiang Hu, Fangying Yu

“…Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with the increasing prevalence of antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due to limited penetration, resistance development, and inadequate local concentration at wound sites. …”
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Pseudogout Associated Hip Pain in a Patient with HIV Infection by Benan M. Dala-Ali, Matthew Welck, Mary Anne Lloyd, Henry D. Atkinson

“…The virus has also been linked to osteonecrosis, osteopenia, bone and joint tuberculosis, and septic arthritis from rare pathogens. However, it is difficult to fully ascertain whether these conditions are related to the HIV infection itself or the HAART (highly active antiretroviral therapy). …”
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Cognitive disorders: Potential astrocyte-based mechanism by Shiyu Li, Yeru Chen, Gang Chen

“…However, our understanding of the precise pathogenic pathways of cognitive defects remains incomplete. …”
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Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction by Paulina Hernández-Ruiz, Alma R. Escalona Montaño, Luis M. Amezcua-Guerra, Héctor González-Pacheco, Elena Niccolai, Amedeo Amedei, María M. Aguirre-García

“…Our findings provide information on the possible contribution of the oral pathogens associated with gut dysbiosis in the development of MI, although further analysis should be performed.…”
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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology by Alise Zagare, Janis Kurlovics, Catarina Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez-Giro, Christian Jäger, Paul Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Egils Stalidzans, Giuseppe Arena, Jens C Schwamborn

“…We combined experimental methods with metabolic modelling to identify the most insulin resistance-dependent pathogenic processes. We demonstrate that insulin resistance compromises organoid metabolic efficiency, leading to increased levels of oxidative stress. …”
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Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges by Inga Brockmann, Juliet Ehrenpfordt, Tabea Sturmheit, Matthias Brandenburger, Charli Kruse, Marietta Zille, Dorothee Rose, Johannes Boltze

“…Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. …”
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MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment by Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Takashi Iwata, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

“…MicroRNAs (miRNAs) are implicated in posttranscriptional regulation of gene expression and in the pathogenic mechanisms of cancer, suggesting their importance in diagnosis and treatment. miRNAs may have roles in the pathogenesis of cervical cancer based on the increases or decreases in several specific miRNAs found in patients with this disease. …”
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STRUCTURAL AND DYNAMIC PROPERTIES OF MUTANTS OF THE SOD1 PROTEIN ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS by N. A. Alemasov, N. V. Ivanisenko, V. A. Ivanisenko

“…In the present paper, we hypothesize that mutant SOD1 aggregation can be facilitated by not only destabilization due to hydrogen bonds disruption but also by formation of new hydrogen bonds, which can stabilize intermediate “pathogenic” conformations of the mutant SOD1 protein. …”
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Digital PCR detection of microsporidia in household pipe water of patients with microsporidial keratitis by Wararee Sriyuttagrai, Auemphon Mordmaung, Tachpon Techarang, Jakkrit Juhong, Dominik H. Kowanz, Lunla Udomwech

“…Level of contamination differed depending on the water source, with households that use untreated water in their plumbing system having significantly higher copies of pathogenic microsporidial DNA. Contrary to traditionally perceived risk from soil contact into eyes, our study identifies household water as an unforeseen potential source of MK. …”
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G alleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates by Dongmei Shi, Zhiya Yang, Wanqing Liao, Chen Liu, Liang Zhao, Huilin Su, Xiaodong Wang, Huan Mei, Min Chen, Yinggai Song, Sybren de Hoog, Shuwen Deng

“…Methods We investigated the pathogenic potential of the fungus in a Galleria mellonella (G. mellonella) larvae infection model. …”
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Novel heterozygous ASH1L nonsense variant involved in mild intellectual disability by Baoqiong Liao, Baoqiong Liao, Wuming Xie, Shuwen He

“…In this study, we describe a patient diagnosed with mild ID, and whole-exome sequencing (WES) of the family identified a novel heterozygous nonsense variant, NM_018489.2: c.2479A > T (p.Lys827*), located in exon 3 of ASH1L, which was predicted to be pathogenic. The nonsense variant in the mild ID patient may disrupt ASH1L function by destabilizing its spatial conformation, leading to decreased activity of the catalytic H3K36 methylation, thereby affecting neurological function. …”
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