Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response by Tomás Lombardo, Guillermo A. Blanco

“…Since preservation of fluid within the coelom is vital for the worm, clotting contributes to rapidly seal the body wall and entrap pathogens upon injury, creating a matrix where wound healing can take place in a second stage. …”
Get full text

New Hosts of Simplicimonas similis and Trichomitus batrachorum Identified by 18S Ribosomal RNA Gene Sequences by Kris Genelyn B. Dimasuay, Orlie John Y. Lavilla, Windell L. Rivera

“…The generated phylogenetic tree yielded three distinct groups mostly with relatively moderate to high bootstrap support and in agreement with the most recent classification. Pathogenic potential of the trichomonads in these hosts still needs further investigation.…”
Get full text

Interaction between Trichoderma asperellum and Bacillus spp. in the biological control of disease in the soya bean by Adeliane Ferreira Braga, Leonardo de Castro Santos, Suellen Polyana da Silva Cunha Mendes, Francielly Abrenhosa Pires, Alaerson Maia Geraldine, Weder Nunes Ferreira Junior

“…In view of this, biocontrol, through the use of biological agents, has become a driving force in controlling these pathogens. The aim of this study was to evaluate the compatibility of microorganisms, and detect the possibility of antagonistic effects, influence on growth, or synergistic action when microorganisms are jointly applied to crops. …”
Get full text

Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…Abstract The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. …”
Get full text

Water pollution, cholera, and the role of probiotics: a comprehensive review in relation to public health in Bangladesh by Md. Rayhan Chowdhury, Ariful Islam, Valentina Yurina, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato

“…Probiotics are promising as an adjunctive approach to existing therapies as they can enhance gut barrier function, induce competitive exclusion of pathogens, and modulate host immune responses. Recent probiotic advancements include engineering strains that disrupt V. cholerae biofilms and inhibit their virulence. …”
Get full text

Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome by Chilakamarti V. Ramana

“…However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. …”
Get full text

AI Methods for Antimicrobial Peptides: Progress and Challenges by Carlos A. Brizuela, Gary Liu, Jonathan M. Stokes, Cesar de laFuente‐Nunez

“…ABSTRACT Antimicrobial peptides (AMPs) are promising candidates to combat multidrug‐resistant pathogens. However, the high cost of extensive wet‐lab screening has made AI methods for identifying and designing AMPs increasingly important, with machine learning (ML) techniques playing a crucial role. …”
Get full text

Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes by Simona Sennato, Silvia Trabalzini, Maria Gioia Fabiano, Domenico Truzzolillo, Edouard Chauveau, Cecilia Bombelli, Federica Rinaldi, Maria Carafa

“…<i>Satureja montana</i> essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. …”
Get full text

Acute Glomerulonephritis in a Child with Chlamydia pneumoniae Infection: A Case Report by Giovanna Vitaliti, Raffaele Falsaperla, Leandra Giunta, Giuseppina Spataro, Venerando Rapisarda, Mario Velardita, Giuseppe Nunnari, Piero Pavone

“…Infectious diseases seem to be an important and independent risk factor for renal failure, but the underlying mechanism of renal involvement during some kinds of infectious diseases is still unclear, even if the literature data report immunomediated and/or autoimmune mechanisms to explain the pathogenic relationship between the two diseases. In paediatric patients, Chlamydia pneumoniae is a rare cause of renal complications and it may manifest in several ways, mainly involving the respiratory system, even if also renal and glomerulalr complications, have been described. …”
Get full text

Live Plague Vaccine Development: Past, Present, and Future by Andrey P. Anisimov, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Svetlana V. Dentovskaya

“…During the last 100 years, vaccine development has evolved from an empirical approach to one of the more rational vaccine designs where the careful selection of antigens and adjuvants is key to the desired efficacy for challenging pathogens and/or challenging populations. To improve immunogenicity while maintaining a favorable reactogenicity and safety profile, modern vaccine design must consider factors beyond the choice of target antigen alone. …”
Get full text

Probiotics fermentation enhanced the bioactive properties of Gnaphalium affine water extract and improved regulation ability of gut microbiota by Qin Zhang, Shiying Yan, YuanYuan Luo, Zixin Meng, Zhihao Yu, Jian Zhao, Xiaojuan Wu, Yiming Tian, Guzhen Cui, Zhenghong Chen, Daoyan Wu

“…Additionally, the G. affine fermented beverages promoted the growth of intestinal probiotics such as Lactobacillus, Bifidobacterium, while inhibiting pathogens like Clostridium, Shigella. Moreover, the G. affine fermented beverages exhibited beneficial effects, including antibacterial, antioxidant, anti-inflammatory activities. …”
Get full text

Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin by M. Tesauro, A. Mascali, O. Franzese, S. Cipriani, C. Cardillo, N. Di Daniele

“…In contrast, a decline of adiponectin levels has been shown to be related to a picture of hypertension: an endothelial dysfunction has been described as the main pathogenic mechanism responsible for this phenomenon.…”
Get full text

The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Unraveling these multifaceted immune-mediated mechanisms provides insights into major depressive disorder’s pathogenic basis and potential biomarkers and targets. …”
Get full text

Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats by Hui Liu, Xuenan Li, Lu Li, Yucai Li, Haiyang Yan, Yong Pang, Wenliang Li, Yuan Yuan

“…Plus, EA induced translocation of lipopolysaccharides (LPS) and the above pathogenic bacteria, disrupted the intestinal barrier, led to gut-liver axis derangement and TLR4 pathway activation in the liver. …”
Get full text

Preparation and Efficacy of Microemulsion Carvacrol-Based Fruit and Vegetable Cleaner and Its Application on Cherry Tomatoes by Yanshuo Wang, Dianjun Sun, Yinghan Zhang, Yichong Zhou, Ruyi Jin, Xiaoli Peng, Jian Li

“…The study found that carvacrol demonstrated a minimum inhibitory concentration (MIC) ranging between 0.25 and 0.5 mg/mL against four foodborne pathogenic bacteria and three spoilage fungi. The formulated cleaner, containing 67 mg/mL of carvacrol, demonstrated superior characteristics (a particle size of 228 nm, an absolute zeta potential of 21.4 mv, and a stability coefficient of 91.2%). …”
Get full text

Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses by Tamana Eskandari, Yasamin Eivazzadeh, Fatemeh Khaleghinia, Fatemeh Kashi, Valentyn Oksenych, Dariush Haghmorad

“…Lipid antigens are presented by CD1 molecules and activate invariant natural killer T (iNKT) cells and group 1 CD1-restricted T cells, whereby they impact immune responses to pathogens and tumors. Recent advances in mass spectrometry, imaging techniques, and lipidomics have revolutionized the identification and characterization of lipid antigens and enhanced our understanding of their structural diversity and functional significance. …”
Get full text

Recipe for Success: Suggestions and Recommendations for the Isolation and Characterisation of Bacteriocins by Ellen Twomey, Colin Hill, Des Field, Máire Begley

“…Although only two peptides have been approved for use as natural preservatives foods, current research is focusing on expanding their application as potential therapeutics against clinical pathogens. Our laboratory group has been working on bacteriocins for over 25 years, and during that time, we have isolated bacteriocin-producing microorganisms from a variety of sources including human skin, human faeces, and various foods. …”
Get full text

Role of mitochondrial and lysosomal dysfunction in acute pancreatitis pathogenesis by Yuliya V Yevsyutina, V. T. Ivashkin, E. Z. Abgadzhava

“…Mitochondrial and lysosomal dysfunction acts as pathogenic basis for AP, leading to energy deprivation of pancreatic cells. …”
Get full text

Chitosan and Its Nanoparticles: A Multifaceted Approach to Antibacterial Applications by Emir Akdaşçi, Hatice Duman, Furkan Eker, Mikhael Bechelany, Sercan Karav

“…Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. …”
Get full text

PCSK9: A Potential Therapeutic Target for Sepsis by Yuan Yuan, Wei Wu, Shanshan Sun, Yi Zhang, Zhi Chen

“…In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol (LDL) receptors (LDL-R) of the hepatocytes and the very low-density lipoprotein cholesterol receptors (VLDL-R) of the adipocytes, which then subsequently reduced pathogenic lipid uptake and clearance/sequestration. …”
Get full text