Porphyric encephalopathy in a 15-year-old girl: A case report by Saihari S Dukkipati, Jordan Terschluse, Drew Thodeson, Angela Beavers, Melissa Muff-Luett, Claire Ives, Sookyong Koh

“…A hydroxymethylbilane synthase (porphobilinogen deaminase) pathogenic variant was found in porphyria gene panel confirming the diagnosis of acute intermittent porphyria. …”
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Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…Summary: Antimicrobial resistance poses a severe threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency. The SOS response to DNA damage is crucial in bacterial evolution, influencing resistance development and adaptability in challenging environments, especially under antibiotic exposure. …”
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Disorder of intracellular cobalamin metabolism: Importance of rapid diagnostic illustrated by a case report of early-onset methylmalonic aciduria and homocystinuria, cobalamin C ty... by Etienne Mondesert, Bastien Baud, Agathe Roubertie, Jean-François Benoist, Pierre-Edouard Grillet, Jean-Paul Cristol, Marie Céline Francois-Heude, Manuel Schiff, Stéphanie Badiou

“…Diagnosis was later confirmed by genetic analysis which identified two pathogenic variants on the MMACHC gene: c.271dupA (p.Arg91lysfs∗14) paternal allele and c.388T > C (p.Tyr130His) maternal allele. …”
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Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots by Dos Santos Delair Silveira, Oberger Júlia Vieira, Niero Rivaldo, Wagner Theodoro, Delle Monache Franco, Cruz Alexandre Bella, Martin-Quintal Zhelmy, Cechinel Filho Valdir

“…The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. …”
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Prevalence and Antibiotic Resistance Patterns of Ocular Bacterial Strains Isolated from Pediatric Patients in University Hospital of Campania “Luigi Vanvitelli,” Naples, Italy by Francesco Petrillo, Veronica Folliero, Biagio Santella, Gianluigi Franci, Francesco Foglia, Maria C. Trotta, Maria T. Della Rocca, Teresio Avitabile, Caterina Gagliano, Marilena Galdiero

“…The study aimed to evaluate the antimicrobial resistance profiles of the main pathogens involved in eye infections. This study involved pediatric patients enrolled at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2019. …”
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Dysphoric spectrum of emotional disorders at irritable bowel syndrome by M. A. Morozova, G. Ye. Rupchev, A. A. Alekseyev, A. G. Beniashvili, M. V. Mayevskaya, Ye. A. Poluektova, O. Z. Okhlobystina, V. T. Ivashkin

“…Somatic manifestations of IBS are associated to dysphoric experience indicating their potential pathogenic value. Imbalance between the scope of data on emotional disorders at IBS and the number of studies devoted to psychopharmacotherapy efficacy assessment at emotional disorders was revealed. …”
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Attempts to identify the molecular cause of autoinflammatory recurrent fever by Oksana Boyarchuk, Diana Savkiv

“…We present the molecular diagnosis results of 12 children with recurrent fever, analyzing the correlation between molecular findings and clinical symptoms. No pathogenic variants confirming autoinflammatory disease were found. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling. Taken together, our findings reveal a macrophage-specific ubiquitination signaling axis in colitis and CAC development and suggest that Pellino1 is a potential candidate for treating chronic inflammation and inflammation-related cancer.…”
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The Promise of Human Induced Pluripotent Stem Cells in Dental Research by Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim, Vijayendran Govindasamy

“…Indeed, this has provided a perfect cell source for disease modeling and a better understanding of genetic aberrations, pathogenicity, and drug screening. In this paper, we will summarize the recent progress of the disease-specific iPSC development for various human diseases and try to evaluate the possibility of application of iPS technology in dentistry, including its capacity for reprogramming some genetic orodental diseases. …”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
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Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…Along with traditional concepts on the risk factors of atherosclerosis and cardio-vascular diseases development one should take into account data on the new pathogenic mechanisms for these diseases. According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
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Recent Advances in Biopesticide Research and Development with a Focus on Microbials [version 4; peer review: 3 approved, 1 approved with reservations] by Dennis Ndolo, Jing Ge, Debbie Muir, Lawrence Malinga, Kahsay Tadesse Mawcha

“…Biopesticides are pest control products derived from natural sources such as microbes, macro-organisms (insects and pathogens), plant extracts, and certain minerals. Many biopesticides are considered environmentally safe and can complement or substitute conventional chemical pesticides. …”
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Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry by Qingping Liang, Wei Zhou, Siyuan Peng, Ziyu Liang, Zhemin Liu, Changliang Zhu, Haijin Mou

“…Bacteriocins produced by LAB have attracted the attentions for application in the food industry as natural food bio-preservatives because of their antimicrobial activity against the food spoilage and pathogenic bacteria. With the increasing demands of consumers for more healthier food and investigations on natural food preservatives, the bioactivity of bacteriocins allows them to give the application values to the bacteriocin-producing LAB. …”
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Impact of population screening for Lynch syndrome insights from the All of Us data by Jiheum Park, Hemanth Karnati, Sheila D. Rustgi, Chin Hur, Xiao-Fei Kong, Fay Kastrinos

“…LS affects about 1 in 354 individuals in this U.S. cohort, where pathogenic variants in the genes MSH6 and PMS2 account for the majority of cases. …”
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Effectiveness of the California Mastitis Test (CMT), Reductase Test, and Alcohol Test for Dairy Cows Subclinical Mastitis Detection by Eriza Rosalina Rochmah, Dadik Raharjo, Sri Hidanah, Mustofa Helmi Effendi, Adiana Mutamsari Witaningrum, Sunaryo Hadi Warsito

“…Mastitis is an inflammation of the mammary glands caused by pathogenic bacteria Mastitis divided into 2 types, clinical mastitis which has symptoms of swelling and changes in the shape of the mammary gland, while subclinical mastitis does not indicate clear symptoms. …”
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Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…In silico analyses predicted low toxicity and potential enzyme inhibition, along with antiprotozoal properties, suggesting these compounds as candidates against protozoan pathogens. Molecular docking confirmed inhibitory potential against trypanothione reductase, supporting antiprotozoal activity. …”
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Follicular T cells and the control of IgE responses by Pablo F. Cañete, Di Yu

“…Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. …”
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Underscoring long-term host-microbiome interactions in a physiologically relevant gingival tissue model by M. Adelfio, G. E. Callen, A. R. Diaz, B. J. Paster, X. He, H. Hasturk, C. E. Ghezzi

“…Abstract The human body houses many distinct and interconnecting microbial populations with long-lasting systemic effects, where the oral cavity serves as a pathogens’ reservoir. The correlation of different disease states strongly supports the need to understand the interplay between the oral tissue niche and microbiome. …”
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FRUIT DAMAGES CAUSED BY BROWN MARMORATED STINK BUGS IN APPLES AND QUINCES by Attila Keseru, Flavia-Andreea Andrecan, Horia Alexandru Pop, Mihai Buta, Orsolya Borsai

“…Feeding injuries also made both fruits more susceptible to secondary infections by pathogens, further reducing their marketability. These findings highlight the economic impact of H. halys on fruit production and emphasize the need for integrated pest management (IPM) strategies. …”
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How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). …”
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