A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. …”
Get full text

Evaluation of serum leptin and adiponectin and their associations with obesity-related renal injury among Egyptian adolescents by Azza A El-Shaheed, Reham F. Fahmy, Nermine N. Mahfouz, Salwa R El-Zayat, Hiba Sibaii, Rehab S.I. Moustafa

“…Conclusion Leptin and adiponectin are the main pathogenic factors for renal injury in obese adolescents.…”
Get full text

Synbiotics in caries prevention: A scoping review. by Mohammed Nadeem Bijle, Manikandan Ekambaram, Edward C M Lo, Cynthia Kar Yung Yiu

“…Future studies are needed to examine the combination of amino acids (esp. arginine) with probiotics as a potential synbiotic against cariogenic pathogens.…”
Get full text

Candiduria in Pediatric Patients: Two Case Reports and a Review of Management Strategies. by Aferdita Ademi, Ferizat Dika Haxhirexha, Agron Dogjani, Kastriot Haxhirexha

“… Introduction: Urinary infections, while common in intensive care and surgical units, present a unique challenge when fungal pathogens are involved. These fungal urinary infections, known as fungiuria, require a more intricate and prolonged treatment plan involving antifungal medications. …”
Get full text

Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis by Xin-Yu Pan, Meng Wang, Yi-Dan Xu, Lin-Nong Wang

“…A total of 287 patients with IK admitted to the Department of Ophthalmology of Nanjing First Hospital between August 2018 and December 2022 were analyzed retrospectively, and the pathogenic causes, etiological characteristics, detection, treatment methods, and efficacy were summarized. …”
Get full text

MOLECULAR TYPING OF METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS AUREUS (MSSA), ISOLATED FROM MONKEYS, BASED ON COAGULASE GENE POLYMORPHISM by V. A. Kalashnikova

“…The lack of information on the genotyping of these pathogens detected in monkeys living in captivity served as a stimulus to conduct a similar research, since staphylococcal infections in the primates are widespread. …”
Get full text

SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject by R. Wumba, M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, J. M. Kayembe

“…Background. The pathogenic mechanisms and immune response of COVID-19 are far from clear. …”
Get full text

Application of Genomic Selection in Beef Cattle Disease Prevention by Ramanathan Kasimanickam, Joao Carlos Pinheiro Ferreira, John Kastelic, Vanmathy Kasimanickam

“…By incorporating genomic technologies such as whole-genome sequencing, genotyping, and transcriptomics, researchers can identify specific genetic variants associated with resistance to pathogens like bovine respiratory disease and Johne’s disease. …”
Get full text

Dual Control of Host Actin Polymerization by a Legionella Effector Pair by M. Pillon, C. Michard, N. Baïlo, J. Bougnon, K. Picq, O. Dubois, C. Andrea, L. Attaiech, V. Daubin, S. Jarraud, E. Kay, P. Doublet

“…Host actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. …”
Get full text

Selective cultivation of bacterial strains with lipolytic and hydrocarbon-oxidizing activity from bottom sediments of the Ob River, Western Siberia by A. I. Gerasimchuk, D. A. Ivasenko, A. A. Kasymova, Yu. A. Frank

“…The phylogenetic and metabolic diversity of the cultivated non-pathogenic bacterial strains with lipolytic and oil-oxidizing activity revealed in the study indicates the biotechnological potential of the isolates. …”
Get full text

Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

Get full text

Contribution of Medical Wards Contamination to Wound Infection among Patients Attending Ruhengeri Referral Hospital by Emmanuel Munyeshyaka, Parfait Cyuzuzo, Callixte Yadufashije, John Karemera

“…These infections are often caused by multidrug-resistant pathogens acquired via improper antibiotic use, not following infection control and prevention procedures. …”
Get full text

Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…Their unique ability to combine high specificity with desirable pharmacokinetic properties makes them valuable tools in addressing unmet medical needs, such as combating drug-resistant pathogens and targeting challenging biological pathways. …”
Get full text

Identification and characterization of antibacterial peptides produced by Lactobacillus plantarum 1407 by Silpa Sajan, Rupachandra Saravanan

“…Introduction: Peptides from lactic acid bacteria provide health benefits and can inhibit the growth of pathogenic organisms. The present work aimed to isolate and characterize peptides with antibacterial activity from Lactobacillus plantarum 1407. …”
Get full text

Application of DNA markers in molecular breeding and genetic studies of grapevine by E. T. Ilnitskaya, M. V. Makarkina

“…The genes for resistance to the most harmful fungal pathogens Plasmopara vitikola, Erysiphe necator are the most studied. …”
Get full text

A Prospective Open-Label Multicentre Trial on the Use of 1 G, Once Daily Ceftriaxone in Lower Respiratory Tract Infections by Donald E Low, Lionel A Mandell

“…A cross-Canada in vitro susceptibility surveillance study of bacterial pathogens. frequently the cause of pneumonia. found ceftriaxone to have minimal inhibitory concentrations in 90% of isolates that would support such a dosing regimen. with the exception of Enterobacter species. …”
Get full text

Construction and evaluation of Brassica rapa orphan genes overexpression library by Mingliang Jiang, Mingliang Jiang, Zongxiang Zhan, Xiaonan Li, Zhongyun Piao

“…Furthermore, the results of stress treatment of 24 BrOGsOE lines with no apparent significant phenotypes suggested that a number of BrOGs have both general and specific functions against environmental and pathogenic stress. The findings of this study provide a comprehensive overview of the roles of BrOGs, emphasizing their significance as a resource for identifying positive genes associated with species-specific characteristics and stress responses and offering a solid foundation for the functional analysis of BrOGs.…”
Get full text

Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for... by Eun Hee Ahn, Jae-Bong Park

“…Microglia possess several receptors that bind with Aβ, triggering the expression and release of an inflammatory factor, although their main physiological function is to phagocytose debris and pathogens in the brain. NF-κB activation plays a major role in neuroinflammation. …”
Get full text

Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review by Susanna Rizzi, Carlotta Spagnoli, Daniele Frattini, Francesco Pisani, Carlo Fusco

“…Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare congenital autosomal recessive metabolic disorder caused by pathogenic homozygous or compound heterozygous variants in the dopa decarboxylase (DDC) gene. …”
Get full text

Olfactory transport efficiency of the manganese oxide nanoparticles (II) after their single or multiple intranasal administrations by A. V. Romashchenko, M. B. Sharapova, D. V. Petrovskii, M. P. Moshkin

“…These results indicate the presence of the natural mechanisms of protection against the penetration of pathogens and xenobiotics into the olfactory epithelium; they also allow us to formulate practical recommendations on intranasal drugs delivery.…”
Get full text