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4121
Selected microwave irradiation effectively inactivates airborne avian influenza A(H5N1) virus
Published 2025-01-01“…Abstract The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. …”
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4122
The Genetic Perspective of Familial Glucocorticoid Deficiency: In Silico Analysis of Two Novel Variants
Published 2020-01-01“…A comprehensive search was conducted to find the reported variants of MC2R and MRAP genes. In silico pathogenic analysis was performed for the reported variants. …”
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4123
In Vitro Antibacterial Activities of Methanolic Extracts of Fruits, Seeds, and Bark of Zanthoxylum armatum DC
Published 2020-01-01“…The fruits, seeds, and bark extracts of Z. armatum exhibited remarkable antibacterial properties against different pathogenic bacteria causing several diseases, which suggests the potential use of this plant for treating different bacterial diseases such as skin infection, urinary tract infection, dental problems, diarrhea, and dysentery.…”
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4124
Transcription factor TCF4: structure, function, and associated diseases
Published 2024-11-01“…This review focuses on the TCF4 gene that encodes a transcription factor crucial for nervous system development and functioning. Pathogenic variants in this gene have been linked to a rare genetic disorder, Pitt–Hopkins syndrome, and TCF4 polymorphic variants are associated with several socially significant diseases, including various psychiatric disorders. …”
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4125
Identification of G-quadruplex-forming Sequences in Nucleocapsid Gene of SARS-CoV-2 Variants of Concern: An In Silico Analysis
Published 2024-02-01“…Therefore, due to the loss of this important PQS or indeed an obstacle to viral replication, the Delta variant could exhibit higher reproduction and pathogenicity than other variants of concern.…”
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4126
The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells
Published 2015-01-01“…Bronchial epithelial cells are the first barrier of defense against respiratory pathogens. Dust particles as extracellular stimuli are associated with inflammatory reactions after inhalation. …”
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4127
Unveiling the prenatal features of HADDS: A case report and literature review
Published 2025-01-01“…The variant is a de novo shifted code mutation, which expands the pathogenic gene spectrum of EBF3. Furthermore, we did a retrospective analysis of HADDS patients with a history of pregnancy and childbirth. …”
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4128
Streptococcus constellatus Peritonitis and Subsequent Septic Shock following Intrauterine Device Removal
Published 2019-01-01“…Streptococcus constellatus is a highly pathogenic organism once a systemic septic infection has become established that can cause an ascending genital tract infection resulting in tubo-ovarian abscess formation, peritonitis, and septic shock.…”
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4129
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
Published 2025-01-01“…Abstract The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. …”
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4130
Elegant and Innovative Recoding Strategies for Advancing Vaccine Development
Published 2025-01-01“…Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens. Recent advancements highlight synonymous recoding’s potential, offering improved genetic stability and immunogenicity compared to traditional methods. …”
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4131
Prevalence and factors associated with multidrug resistant Escherichia coli carriage on chicken farms in west Nile region in Uganda: A cross-sectional survey.
Published 2025-01-01“…Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. …”
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4132
Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes
Published 2024-01-01“…As a result, this study compared the genomes of selected H. pylori isolates from selected areas of Africa and evaluated their virulence and antibiotic drug resistance, those that are highly pathogenic and are associated with specific clinical outcomes and those that are less virulent and rarely associated with clinical outcomes. 146 genomes of H. pylori isolated from selected locations of Africa were sampled, and bioinformatic tools such as Abricate, CARD RGI, MLST, Prokka, Roary, Phandango, Google Sheets, and iTOLS were used to compare the isolates and their antibiotic resistance or susceptibility. …”
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4133
Bacteriological valuations of some powdered infant milk and antibiotic resistance estimation
Published 2022-07-01“… Background and objectives: Milk is one of the widely consumed products in the world, highly susceptible to contamination by microorganisms and it is also a suitable medium for the rapid growth and multiplication of bacteria at favorable temperatures, infant formula (baby milk) contain purified cow's milk whey and casein as a protein source, the high nutrient contents of infant formula provide a good growth medium for bacterial pathogens. This study aimed to evaluate the prevalence of bacterial contamination in powder milk sold in local market of Erbil city, and to determine their antibiotic susceptibility . …”
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4134
Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease
Published 2025-02-01“…Jiamin Zhu,1,* Zhen Zhang,1,2,* Yanhui Chu,1,* Zhongyin Xie,1 Dongmei Zeng,1 Lijiao Jin,1 Luxin Li1 1Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 2School of First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luxin Li, Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157000, People’s Republic of China, Tel +86 13763617174, Email liluxin@mdjmu.edu.cnAbstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. Currently, therapies and their efficacy for kidney diseases are limited. …”
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4135
Ditch management using low-grade weirs: an opportunity for mitigating water quality and quantity impacts
Published 2025-01-01“…Transport of sediment, pathogens, pesticides, and nutrients from runoff and drainage from crop fields contributes to eutrophication and degradation of surface waters. …”
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4136
Modification of Medium Composition for Enhancing the Production of Antifungal Activity from Xenorhabdus stockiae PB09 by Using Response Surface Methodology
Published 2018-01-01“…Xenorhabdus stockiae PB09 bacterium has been shown to exhibit antifungal activity against several plant pathogens. To improve its efficacy, the optimization of the nutritional components in culture media was performed. …”
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4137
Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea
Published 2025-01-01“…The ML061-4 genome was evaluated for genes associated with complex carbohydrate metabolism, bacterial adhesion, virulence factors, pathogenicity, bacteriophages, antiviral defence systems as well as toxin- and antibiotic-resistance associated genes, and genes involved in toxin production, secondary metabolite biosynthesis and xenobiotics biodegradation. …”
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4138
Microcephalic osteodysplastic primordial dwarfism type II in four Indian children with PCNT variants
Published 2025-01-01“…Conclusion All four patients had significant microcephaly and growth retardation and the new variants were found to be likely pathogenic by in silico analysis. Early detection of the syndrome is essential for early interventions, proper genetic counseling and prenatal diagnosis.…”
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4139
Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients
Published 2020-12-01“…Staphylococcus aureus the most notorious pathogens causes morbidity and mortality especially in burn patients. …”
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4140
Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro
Published 2025-02-01“…Bingquan Li,1,* Boyang Dong,1,* Liangzhen Xie,2 Yan Li2 1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Ear-Nose-Throat Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liangzhen Xie; Yan Li, Email xieliangzhen888111@163.com; liyan888111@163.comAbstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, and society, particularly in the context of accelerating globalization and increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, and several decongestants. …”
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