Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma by Yujuan Sun, Nan Liu, Xiaobing Guan, Hongru Wu, Zheng Sun, Hui Zeng

“…We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. The occurrence of regulatory T-cells (Tregs) and tumor-associated macrophages (TAMs) and the expression of anti-inflammatory cytokines and proinflammatory cytokines were investigated in OLK, OLP, and OSCC tissues. …”
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Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract by S. Anbazhagi, A. Murugesan, M. Paramanantham, K. Chinnaiah, Karthik Kannan, Nadezhda Palko, K. Gurushankar

“…The CuS–ZnO nanocomposite significantly exhibited antimicrobial activity against the pathogens of S. aureus (21 mm-zone of inhibition) and E.coli (25 mm-zone of inhibition). …”
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Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China by Lei Wang, Yuzhu Dai, Jun Cheng, Changgui Sun, Yu Chen, Dawei Cui

“…Enterovirus 71 (EV-A71) is one of the most pathogens to hand, foot, and mouth disease (HFMD) as well as neurological complications in young children. …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Furthermore, RT-qPCR revealed a substantial reduction of SPAG9 gene expression at the mRNA level in the affected individuals of both families, thus supporting the pathogenic nature of the identified variant. For the first time in the literature, biallelic SPAG9 gene variation was linked to multisystem-exhibiting features like coarse facial features, albinism, cataracts, skeletal abnormalities, and developmental delay. …”
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The mutational spectrum of NRAS gene discovers a novel frameshift mutation (E49R) in Saudi colorectal cancer patients by Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Abdulrahman Sibiany, Mohammed Saad Alamri, Samer Mohammed Hassan Alqarni, Irfan A. Rather, Adeel G. Chaudhary, Sajjad Karim, Peter Natesan Pushparaj

“…The aim of this study was to identify pathogenic mutations in the NRAS gene causing colorectal cancer in the Saudi population. …”
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Large Rearrangements in Genes Responsible for Familial Adenomatous Polyposis, <i>MUTYH</i>-Associated Polyposis and Peutz–Jeghers Syndrome in Russian Patients by A. N. Loginova, Yu. A. Shelygin, V. P. Shubin, A. M. Kuzminov, D. Yu. Pikunov, T. A. Saveleva, A. S. Tsukanov

“…Routine use of MLPA method makes it possible to increase the total frequency of detection of pathogenic variants in the APC and STK11 genes above 90 %. …”
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Establishment of a Mutant Library for Infection Cushion Development and Identification of a Key Regulatory Gene in <i>Botrytis cinerea</i> by Maoyao Tang, Kexin Wang, Pan Zhang, Jie Hou, Xiaoqian Yu, Hongfu Wang, Yangyizhou Wang, Guihua Li

“…Our findings provide valuable insights into the genetic and molecular basis of IC formation and offer new targets for controlling <i>B. cinerea</i> pathogenicity.…”
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Effects of Lactiplantibacillus plantarum HNU082 intervention on fungi and bacteriophages in different intestinal segments of mice by Xinlei Liu, Zhe Han, Wenyao Ma, Weipeng Cui, Dongyu Zhen, Shuaiming Jiang, Jiachao Zhang

“…The relative abundance of pathogenic fungi, such as Candida albicans, decreased in the small intestine. …”
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Goat-derived cell line (<i>Capra hircus</i>) TCh generated by karyological and morphological transformation of YаDK-04 CCL during subcultivation with lanthanide-treated bovine seru... by E. A. Trofimova, S. V. Kononova, I. N. Shumilova, B. L. Manin

“…The novel continuous cell line proved to be suitable for effective reproduction of such disease pathogens as lumpy skin disease, sheep pox, peste des petits ruminants agents. …”
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Beneficial effects of AOS-iron supplementation on intestinal structure and microbiota in IDA rats by Hong He, Hui Teng, Qun Huang, Dan He, Fengping An, Lei Chen, Hongbo Song

“…At the genus level, the beneficial microbiota was enriched in AOS-iron groups, but the relative abundance of potential opportunistic pathogens obviously reduced compared to that in the anemia model (AM) group. …”
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Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection by Cucunawangsih Cucunawangsih, Ratna Sari Wijaya, Nata Pratama Hardjo Lugito, Ivet Suriapranata

“… Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to increased vascular permeability, coagulopathy, and platelet dysfunction, a hallmark of severe dengue. …”
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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…Diabetic kidney disease is one of the common complications in diabetic patients and has gradually become an important pathogenic factor in chronic kidney disease. Therefore, studying the mechanisms of its occurrence and development is of great significance for the prevention and treatment of diabetic kidney disease. …”
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Metabolic disorders as a factor in pathogenesis of infectious diseases in cattle by A. D. Alekseev

“…High-yielding dairy cows with intense metabolism are especially sensitive to errors in feeding practices, because even minor nutritional or mineral deficiencies cause metabolic disorders leading to immunodeficiency conditions, reduced resistance to infectious agents and raised sensitivity to infections with pathogenic and opportunistic microorganisms. Besides some infections, for example acute respiratory diseases, also result in metabolic disorders, immunosuppression, decrease in the overall resistance of the organism and ultimately in mixed infections. …”
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New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia by Raha Orfali, Shagufta Perveen

“…All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176. …”
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Comparative Study of Antibacterial Activity of Cistus ladanifer L. Leaves Extracted by Ultrasound-Assisted Extraction and Maceration by Houda Chtibi, Kaoutar Harboul, Taofiq Benali, Abdelhakim Bouyahya, Khabbach Abdelamjid, Said Louahlia, Jactty Chew, Long Chiau Ming, Khalil Hammani

“…These outcomes have underscored the presence of active compounds within Cistus ladanifer L. that could serve as potential alternatives to antibiotics against some of the most pathogenic bacterial species. …”
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GC-MS Analysis and Study of the Antimicrobial Activity of Citrus paradisi, Citrus aurantifolia, and Citrus sinensis Peel Essential Oils as Hand Sanitizer by Isra Osman Mohammed, Ayat Ahmed Alrasheid, Saad Mohammed Hussein Ayoub

“…In the setting of healthcare, the use of hand sanitizers and antiseptics for hand hygiene is of paramount importance to avoid transfer of pathogenic microorganism through hand and skin contact. …”
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Antimicrobial Resistance in Poultry Farming: A Look Back at Environmental Escherichia coli Isolated from Poultry Farms during the Growing and Resting Periods by Sukanya Thongratsakul, Patamabhorn Amavisit, Chaithep Poolkhet

“…During the production cycle of poultry farms, pathogens may remain in the next cycle of rearing young chickens. …”
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Bio-Tribocorrosion of Titanium Dental Implants and Its Toxicological Implications: A Scoping Review by Sumit Gaur, Rupali Agnihotri, Sacharia Albin

“…., Ti6Al4V alloy, is most susceptible to tribocorrosion. Oral pathogens like Streptococcus mutans and Porphyromonas gingivalis produce acids and lipopolysaccharides (LPS) that cause pitting corrosion and degrade the TiO2. …”
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An Emerging Role for IQGAP1 in Regulating Protein Traffic by Mahasin Osman

“…Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus, elucidating the mechanisms of cellular traffic will be important in order to understand the basis of a wide range of inherited and acquired human diseases. …”
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