From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota by Hamed Tahmasebi, Neda Arjmand, Marzieh Monemi, Ali Babaeizad, Farnaz Alibabaei, Negar Alibabaei, Aisa Bahar, Valentyn Oksenych, Majid Eslami

“…Industrialization and environmental factors have exacerbated this issue, contributing to a rise in infections with multidrug-resistant (MDR) bacteria, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and carbapenem-resistant <i>Enterobacteriaceae</i>. These resistant pathogens compromise the effectiveness of essential treatments like surgical prophylaxis and chemotherapy, increase healthcare costs, and prolong hospital stays. …”
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Phenotypic variability and the gender paradox in the R363C variant of Fabry disease by Alison C. Leslie, Jeanine Jarnes, Alia Ahmed, Sofia Shrestha, Jeffrey Wang, Chester B. Whitley, Nishitha R. Pillai

“…A family is presented here with a 36‐year‐old female who is symptomatic with chronic kidney disease and her oligosymptomatic 70‐year‐old father, both of whom have a heterozygous and hemizygous GLA pathogenic variant, respectively, c.1087C>T (p.R363C). …”
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Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line by Santosh Mallikarjun Bhavi, Bothe Thokchom, Sapam Riches Singh, Sukesh Kumar Bajire, Rajesh P. Shastry, B. S. Srinath, Shivanand S. Bhat, Kotresha Dupadahalli, Chandramohan Govindasamy, Swati Ravi Chalekar, B. P. Harini, Ramesh Babu Yarajarla

“…Additionally, SM-AgNPs increased Caenorhabditis elegans survival and reduced paralysis under pathogenic bacterial exposure. This study demonstrates the potential of SM-AgNPs in biomedical applications, emphasizing selective anticancer activity and antimicrobial effects in vivo.…”
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Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking by Abdullah Haikal, Mahmoud Kamal, Eslam M. Hosni, Yhiya Amen

“…Culex pipiens, commonly known as the northern house mosquito, is a major vector of several human pathogens, such as the West Nile virus and filariasis, making it a key target in the fight against vector-borne diseases. …”
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Release of Gentamicin and Vancomycin from Preformed Spacers in Infected Total Hip Arthroplasties: Measurement of Concentrations and Inhibitory Activity in Patients’ Drainage Fluids... by Dario Regis, Andrea Sandri, Elena Samaila, Anna Benini, Manuel Bondi, Bruno Magnan

“…The inhibitory activity of drainage fluids showed substantial intersubject variability related to antibiotic concentrations and differed according to the pathogens tested. Gentamicin and vancomycin were released from temporary hip spacers at bactericidal concentrations, and their use in combination exerted strong inhibition against methicillin-resistant S. aureus and Coagulase Negative Staphylococci strains.…”
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Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management by Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi

“…Abstract Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. …”
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Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes by Radiet Anbessie Tirkeso, Tilahun Wubalem Tsega, Gebru G/Tsadik Amdemichael

“…As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going. …”
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Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity by Yaping Zhang, Lars Edvinsson, Cang-Bao Xu

“…This review focuses on cigarette smoke exposure that induces activation of intracellular mitogen-activated protein kinase (MAPK) and subsequently results in the up-regulation of endothelin receptors in the vasculature and airways, which mediates vascular and airway hyper-reactivity, one of the important pathogenic characteristics of cardiovascular and airway diseases. …”
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Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review by Rhesa Muhammad Faisal, Olusola Olaitan Ayeleru, Helen Uchenna Modekwe, Ishmael Matala Ramatsa

“…These tools are useful for detecting cell cultures, food pathogens, biomedical, energy, and disease. The affordability, versatility, biocompatibility, strength, and transparency of thermoplastics have contributed to its widespread use in the commercialization of microfluidic chips. …”
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Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex by Harald Bernhard, Hana Petržílková, Barbora Popelářová, Kamil Ziemkiewicz, Karolina Bartosik, Marcin Warmiński, Laura Tengo, Henri Gröger, Luciano G. Dolce, Cameron D. Mackereth, Ronald Micura, Jacek Jemielity, Eva Kowalinski

“…Abstract Kinetoplastids are a clade of eukaryotic protozoans that include human parasitic pathogens like trypanosomes and Leishmania species. …”
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Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase by Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz

“…Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans. …”
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Bacteriophage Treatment Induces Phenotype Switching and Alters Antibiotic Resistance of ESBL <i>Escherichia coli</i> by Árpád Rózsa, László Orosz, Nikoletta Szemerédi, Gabriella Spengler, Gábor Kecskeméti, Otília Vágó, Károly Péter Sárvári, Diana Szabó, Zoltán Szabó, Katalin Burián, Dezső Péter Virok

“…<b>Background/Objectives:</b> Bacteriophage therapy represents a promising strategy to combat multidrug-resistant pathogens, such as <i>Escherichia coli</i>. In this study, we explored the effects of a bacteriophage infection on an Extended Spectrum Beta-Lactamase (ESBL) positive <i>E. coli</i> isolate. …”
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Insects Induced Mango Fruit Rot: Unraveling the Culprits by Sivagami Subramaniam, Noor Aisyah Md Noordin, Noor Azrizal-Wahid, Nur Ain Izzati Mohd Zainudin

“…Mango fruit rot caused by insects and microbes has become a significant threat to mango production in Southeast Asia and worldwide. Insect plant pathogens affect crop yields' profitability, quality, and quantity. …”
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Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis by Marcos Vinicius da Silva, Monique Gomes Salles Tiburcio, Juliana Reis Machado, Djalma Alexandre Alves Silva, Denise Bertulucci Rocha Rodrigues, Virmondes Rodrigues, Carlo Jose Freire Oliveira

“…Additionally, many new roles and cellular sources have been described for IL-10, demonstrating a critical role for this cytokine as regulatory, rather than merely pathogenic cytokine, involved in the establishment of chronic latent infection, in the clinical cure after treatment and in keeping antibacillary effector mechanisms active to prevent immune-mediated damage.…”
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Efficacy of bacteriophages with Aloe vera extract in formulated cosmetics to combat multidrug-resistant bacteria in skin diseases by Sodaf A. Maan, Abeer A. Faiesal, Gamar M. Gamar, Noha K. El Dougdoug

“…Abstract Phage therapy offers a promising alternative to antibiotic treatment for combating illnesses caused by multidrug-resistant bacteria. In this study, pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa were isolated from pus and skin infected fluidsusing selective media. …”
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The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis by Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen

“…This imbalance encompasses impaired lamellar membrane integrity, heightened exposure to epidermal pathogens, and the regulation of innate and adaptive immunity. …”
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AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis by Manikandan Palrasu, Khadija Kakar, Amarnath Marudamuthu, Hamida Hamida, Shruthi Thada, Yin Zhong, Shanieka Staley, Philip Brandon Busbee, Jie Li, Monica Garcia-Buitrago, Mitzi Nagarkatti, Prakash Nagarkatti

“…Alpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues and inflammatory signals in neutrophils and Paneth cells in the small intestine, which suggests that it plays a role in microbial homeostasis in the gut. …”
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Evolutionary Insights into IL17A in Lagomorphs by Fabiana Neves, Joana Abrantes, Tereza Almeida, Paulo P. Costa, Pedro J. Esteves

“…In leporids, IL17A had been implicated in the host defense against extracellular pathogens, such as Francisella tularensis that infects hares and rabbits and causes the zoonotic disease tularemia. …”
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Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy by Ali Sakhdari, Guilin Tang, Lawrence E. Ginsberg, Cheryl F. Hirsch-Ginsberg, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Roberto N. Miranda

“…The concomitant detection of ATM mutation in CLL and T-PLL components raises the possibility of a common pathogenic mechanism.…”
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Zymography of proteases in honey bees (Apis Mellifera) infected with Nosema ceranae by Doghuzlu Mohammad Afrasiabi, Nabian Sedigheh, Paghaleh Gholam Ali Nehzati, Taheri Mohammad, Asadollahi Zahra, Akhzari Soheila

“…Evidence suggests that in the coming years, Nosema ceranae, which is less sensitive to fumagillin, could replace Nosema apis as the predominant pathogenic Nosema. Identifying and developing drugs that target these microsporidia without having serious effects on host bee physiology is essential for controlling nosemosis, and this requires information about bee enzymes. …”
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