Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1-related Parkinson’s disease by Peng Liu, Fan Zhang, Xinhui Chen, Xiaosheng Zheng, Miao Chen, Zhiru Lin, Shuqi Chen, Lebo Wang, Xinchen Wang, Nan Jin, Chenxin Ying, Fei Xie, Bo Wang, Sheng Wu, Zhidong Cen, Wei Luo

“…RNA foci were detected in the (AGGGG)exp-expressed HEK293T cell line as well as (AAGGG)exp and (ACAGG)exp, supporting (AGGGG)exp as a novel pathogenic repeat motif. This work revealed complex genotypes with novel repeat configuration of (AGGGG)exp and possible somatic (AATGG)exp insertion in RFC1-related PD.…”
Get full text

Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…Myeloid C-type lectin receptors (CLRs) constitute a large family of transmembrane carbohydrate-binding receptors that recognize pathogens as well as endogenous glycoproteins. Several lines of evidence demonstrate that some CLRs can inhibit the immune response. …”
Get full text

Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups by Ali Yaseen, Jaleel Samanje, Qahtan Adnan Rasheed, Rafah Sabah Barrak, Afraa Brahim

“…Methicillin-resistant Staphylococcus aureus (MRSA) is among the most essential multidrug-resistant bacterial pathogens. The study aimed to determine the prevalence of (MRSA) from different clinical samples to emphasise the suitable treatment. …”
Get full text

Antibiotic resistance gene occurrence in poultry farms in northeast Brazil by Henrique Francisco de Almeida, Paulo Ricardo Conceição Marques Trindade, César Roberto Viana Teixeira, Claudson Oliveira Brito, Silvio Santana Dolabella, Sona Jain, Maíra Pompeu Martins, Ana Andréa Barbosa

“… The misuse of antibiotics in food-producing animal farming practices exerts selective pressure on bacterial strains, intensifying the spread of pathogenic and commensal bacteria carrying antibiotic resistance genes (ARGs). …”
Get full text

Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents by Johana Zúñiga-Miranda, Rebeca González-Pastor, Saskya E. Carrera-Pacheco, Cristina Rodríguez-Pólit, Carlos Barba-Ostria, Antonio Machado, Linda P. Guamán, Christian D. Alcivar-León, Jorge Heredia-Moya

“…In this studio, a series of Schiff bases 3a–h derived from 4-aminoantipyrine and substituted cinnamaldehydes were evaluated in vitro against liver (HepG2) and thyroid (THJ29T) cancer cells, Gram-positive and Gram-negative multidrug-resistant bacteria, and biofilm-forming pathogens. Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. …”
Get full text

Characterization of fermentation liquid from mangrove leaves Avicennia marina and its inhibitory potential for bacterium causing ice-ice disease by Samsu Adi Rahman, Sukenda, Widanarni, Alimuddin, Julie Ekasari

“…This study aimed to identify bacteria and the compounds in fermentation liquid of mangrove leaves A. marina and measured their inhibitory capacity against pathogenic bacteria Stenotrophomonas maltophilia which causes ice-ice disease in seaweed. …”
Get full text

Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case by Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Maria Reyes-Batlle, Carmen M. Martín-Navarro, Jacob Lorenzo-Morales

“…The phylogenetical analysis as well as the sequencing of the acquired amplified product for the DF3 region of the amoebae isolate confirmed that it belongs to genotype T3, which includes other pathogenic amoebae; besides the activity of two drugs currently used against Acanthamoeba was tested on A. griffini.…”
Get full text

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway by Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung

“…Abstract Background Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). …”
Get full text

Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccina... by Caroline Kuhn, Holm Zerbe, Hans-Joachim Schuberth, Anke Römer, Debby Kraatz-van Egmond, Claudia Wesenauer, Martina Resch, Alexander Stoll, Yury Zablotski

“…Prepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. …”
Get full text

EVALUATION OF REFILLABLE DRINKING WATER QUALITY BASED ON MPN COLIFORM AND ESCHERICHIA COLI INSESETAN VILLAGE, SOUTH DENPASAR, BALI by Pande Nyoman Tri Saguna Wyasena, Ni Luh Gede Sudaryati, I Putu Sudiartawan, I Made Dwi Mertha Adnyana

“…However, the quality of refilled drinking water has been tainted with pathogens that can cause health problems. Purpose: To assess the quality of replenished drinking water in Sesetan Village using Most Probable Number (MPN) Coliform and Escherichia coli as indicators. …”
Get full text

Comparison of Biofilm and Attachment Mechanisms of a Phytopathological and Clinical Isolate of Klebsiella pneumoniae Subsp. pneumoniae by Adriana Marcia Nicolau Korres, Gloria Maria de Farias V. Aquije, David S. Buss, Jose Aires Ventura, Patricia Machado Bueno Fernandes, Antonio Alberto Ribeiro Fernandes

“…It is almost impossible to prevent the contact of clinically pathogenic bacteria with food crops, and if they can persist there, they can reenter the human food chain and cause disease. …”
Get full text

Human adaptation and diversification in the Microsporum canis complex by Xin Zhou, Sarah A. Ahmed, Chao Tang, Maria Eduarda Grisolia, José Francisco Ghignatti Warth, Kristen Webster, Andrea Peano, Silke Uhrlass, Claudia Cafarchia, Marie Pierre Hayette, Rosalie Sacheli, Tadeja Matos, Yingqian Kang, G. Sybren de Hoog, Peiying Feng

“…These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. …”
Get full text

Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female by Kathryn E. Kalata, Christina Osborne, Amy Willis, Kacey Navarro, Laura Z. Fenton, Christiana Smith

“…This highlights the importance of maintaining a broad differential for opportunistic infections, especially among those who have spent a significant amount of time in a country where unusual pathogens may be more common. This case also considers the utility of antigen testing as a sensitive diagnostic test in immunocompromised patients.…”
Get full text

He-Plasma Jet Generation and Its Application for E. coli Sterilization by Tiejian Liu, Yuxuan Zeng, Xin Xue, Yinyi Sui, Yingying Liang, Fushan Wang, Fada Feng

“…Atmospheric pressure plasma jet (APPJ) is a promising technique for the sterilization of pathogenic microorganisms in an ambient environment. …”
Get full text

Nosocomial Isolates and Their Drug Resistant Pattern in ICU Patients at National Institute of Neurological and Allied Sciences, Nepal by Pashupati Bhandari, Ganesh Thapa, Bharat Mani Pokhrel, Dwij Raj Bhatta, Upendra Devkota

“…This study was carried out from June 2011 to May 2012 at National Institute of Neurological and Allied Sciences Kathmandu, Nepal, with a view to determining drug resistant pathogens along with detection of extended spectrum β-lactamase (ESBL), AmpC β-lactamase (ABL), and metallo-β-lactamase (MBL) producing bacteria causing infection to ICU patients. …”
Get full text

Can Gut Microbiota Analysis Reveal <i>Clostridioides difficile</i> Infection? Evidence from an Italian Cohort at Disease Onset by Roberto Rosato, Gianluca Quaranta, Giulia Santarelli, Giovanni Fancello, Delia Mercedes Bianco, Francesca Romana Monzo, Stefano Bibbò, Giovanni Cammarota, Maurizio Sanguinetti, Luca Masucci, Flavio De Maio

“…A diverse and well-functioning gut microbiota normally serves as a protective shield against the invasion of harmful bacteria or the proliferation of opportunistic pathogens. <i>Clostridioides difficile</i> infection (CDI) is predominantly associated with the overuse of antibiotics, resulting in a significant alteration in the gut’s microbial balance. …”
Get full text

OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma by Cheng-Jang Wu, Pin-Hsun Tseng, Cheng-Chi Chan, Sara Quon, Li-Chen Chen, Ming-Ling Kuo

“…The results obtained in this study lead us to propose a potential novel adjuvant for clinical use such as prophylactic vaccination for pathogens and immunotherapy in atopic diseases.…”
Get full text

A novel isothermal whole genome sequencing approach for Monkeypox Virus by Matthias Licheri, Manon Flore Licheri, Lukas Probst, Cora Sägesser, Pascal Bittel, Franziska Suter-Riniker, Ronald Dijkman

“…Whole genome sequencing (WGS) has been successfully used to keep track of viral evolution during outbreaks or for surveillance of multiple pathogens of public health significance. Current WGS protocols for MPXV are either based on metagenomic sequencing or tiled-PCR amplification. …”
Get full text

Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion by Liguo Zhang, Zhao Li, Yajing Fu, Haoyang Tian, Ting Wang, Hongrui Liu, Jianhua Li, Hong Liu, Shaohua Ge, Baojin Ma

“…Furthermore, the nanoengineered HAp layer deters pathogenic colonization due to the low adhesion force, which can effectively prevent the formation of bacterial biofilms and infection after implantation. …”
Get full text

Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Genetic analysis corroborated NF1 with a pathogenic variant in the NF1 gene. The patient’s clinical manifestations, coupled with the presence of café-au-lait spots and axillary freckles, supported the diagnosis of NF1. …”
Get full text