Peptide nucleic acid-immobilised paper combined with multiplex recombinase polymerase amplification for the ultrasensitive and rapid detection of rifampicin-resistant tuberculosis by Nuttapon Jirakittiwut, Panuwat Sathianpitayakul, Pitak Santanirand, Yukihiro Akeda, Tirayut Vilaivan, Panan Ratthawongjirakul

“…Our proof-of-concept assay displayed high accuracy (100% for detecting mutations at codons 516, 526, and 531), a short turnaround time (110 min), no cross-reactivity with other bacterial pathogens, and ultrasensitivity. This PNA-paper-based sensor model can be a valuable diagnostic tool for RR-TB detection, providing an accessible diagnostic platform that can be advantageous in resource-limited settings where sophisticated laboratory infrastructure may be lacking.…”
Get full text

<i>Candida auris</i> Antifungal Resistance, Virulence and Susceptibility to a Novel Nitric Oxide-Releasing Microparticle and Its Correlations to Clade Identification by Alessandro F. Valdez, Flora Bohner, Joshua P. Goldman, Ali B. Jaquiery, Eduardo V. C. do Amaral, Dario Correa-Junior, Andrew Draganski, Leonardo Nimrichter, Joshua D. Nosanchuk, Daniel Zamith-Miranda

“…<i>Candida auris</i> is a globally emerging pathogenic fungus described in Japan in 2009. This fungus has been identified mainly in nosocomial environments, associated with a high frequency of multidrug-resistant strains, and mortality rates reach 60%. …”
Get full text

The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…Growing evidence suggests that inflammation is an important pathogenic mediator in the development of diabetes mellitus. …”
Get full text

Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood by Klara Mareckova, Ana Paula Mendes-Silva, Martin Jáni, Anna Pacinkova, Pavel Piler, Vanessa F. Gonçalves, Yuliya S. Nikolova

“…The novel FI score was calculated based on 7 potentially pathogenic mtDNA variants. Greater FI score of mtDNA variants was associated with older epigenetic age in the early 20s and older biological age in the late 20s. …”
Get full text

4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation by Ying Gu, Hsi-Ming Lee, Nicole Napolitano, McKenzie Clemens, Yazhou Zhang, Timo Sorsa, Yu Zhang, Francis Johnson, Lorne M. Golub

“…Endotoxin (lipopolysaccharide, LPS), derived from gram-negative periodonto-pathogens, can induce the local accumulation of mononuclear cells in the inflammatory lesion, increasing proinflammatory cytokines and matrix metalloproteinases (MMPs). …”
Get full text

Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Produced by immune and epithelial cells, they serve as natural defenses against a wide range of pathogens, including bacteria, viruses, and fungi. …”
Get full text

Comparison of chemical constituents in Lysimachia species and their antimicrobial activity for extending the shelf life of foods by Li-Li Chen, Shuang Long Yang, Ji-Cun Bao, Wei-You Xie, Zhao-Chan Wang, Nian Shi, Zhao-Jie Wang

“…The KBZZC-05, 21, and 23 inhibited both spoilage organisms and foodborne pathogens (MICs = 2–256 μg/mL) better than potassium sorbate (MIC >256 μg/mL). …”
Get full text

Evasion of Early Antiviral Responses by Herpes Simplex Viruses by Paula A. Suazo, Francisco J. Ibañez, Angello R. Retamal-Díaz, Marysol V. Paz-Fiblas, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González

“…Besides overcoming physical constraints, such as extreme temperatures, reduced humidity, elevated pressure, and natural predators, human pathogens further need to overcome an arsenal of antimicrobial components evolved by the host to limit infection, replication and optimally, reinfection. …”
Get full text

Examination of the Anaerobic Growth of Campylobacter concisus Strains by Hoyul Lee, Rena Ma, Michael C. Grimm, Stephen M. Riordan, Ruiting Lan, Ling Zhong, Mark Raftery, Li Zhang

“…This study provides useful information in understanding the natural colonization site and pathogenicity of C. concisus.…”
Get full text

Food Pathways of <i>Salmonella</i> and Its Ability to Cause Gastroenteritis in North Africa by Mohamed-Yousif Ibrahim Mohamed, Hazim O. Khalifa, Ihab Habib

“…Infections caused by human pathogenic bacteria in food sources pose significant and widespread concerns, leading to substantial economic losses and adverse impacts on public health. …”
Get full text

Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation by Ting Shen, Jing Yu, Bin Xie, Cuiping Huang, Jingjie Cui, Kefu Liu, Chunyu Liu, Chao Chen

“…Summary: Genome-wide association studies (GWASs) have identified numerous genomic loci linked to schizophrenia (SCZ), while their pathogenic mechanisms largely remain unclear. This study demonstrated protein arginine methyltransferase 7 (PRMT7) as a key target of SCZ risk SNPs with allele-specific enhancer activity at 16q22.1. …”
Get full text

Effect of Candida albicans’ supernatant on biofilm formation and virulence factors of Pseudomonas aeruginosa through las/rhl System by Ke Zhang, Yingying Huang, Yuting Jiang, Tangjuan Liu, Jinliang Kong, Shuangqi Cai, Zhongwei Wen, Yiqiang Chen

“…Abstract Pseudomonas aeruginosa (P. aeruginosa) and Candida albicans (C. albicans) are opportunistic pathogens whose mixed infections can exacerbate microbial dissemination and drug resistance, contributing to high mortality and morbidity rates among infected individuals. …”
Get full text

Bioconversion of municipal organic solid waste in to compost using Black Soldier Fly (Hermetia Illucens) by Priscilla Addo, Sampson Oduro-Kwarteng, Samuel Gyasi, Esi Awuah

“…After the composting process most heavy metals like Fe had insignificantly increased in the compost .Conclusion It can be concluded that larval composting enhance the regrowth of pathogens since the process is entirely mesophilic. …”
Get full text

Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…Contractility disorders along with increased lithogenicity followed by cyclooxygenase-2 overactivation in biliary tract tissue play significant pathogenic role; putative change in bile acid composition may be involved as well. …”
Get full text

Evolutionary Trajectories of Shoots vs. Roots: Plant Volatile Metabolomes Are Richer but Less Structurally Diverse Belowground in the Tropical Tree Genus <i>Protium</i> by Katherine D. Holmes, Paul V. A. Fine, Italo Mesones, Julieta Alvarez-Manjarrez, Andressa M. Venturini, Kabir G. Peay, Diego Salazar

“…Plants also experience strong pressure from enemies such as belowground pathogens; however, little work has been carried out to examine the evolutionary trajectories of species’ specialized chemistries in both roots and leaves. …”
Get full text

Hypercalcemia and co-occurring TBX1 mutation in Glycogen Storage Disease Type Ib: case report by Zakaria Kasmi, Imane Ain El Hayat, Zahra Aadam, Abderrahmane Errami, Ibtihal Benhsaien, Jalila EL Bakkouri, Dalal Ben Sabbahia, Meryem Atrassi, Ahmed Aziz Bousfiha, Fatima Ailal

“…Genetic testing confirmed a homozygous pathogenic variant in SLC37A4 and a heterozygous variant of uncertain significance in TBX1. …”
Get full text

Reexamination In Vitro and In Situ of an Antibacterially Modified Experimental Dental Resin Composite with Molecular Methods: A Pilot Study by Birgit Henrich, Ilka Hermann, Mara Di Giulio, Karl Köhrer, René Deenen, Sugi Sivalingam, Ulrike Peters, Thomas Beikler, Ralf Janda, Stefan Rüttermann

“…To introduce additional methods to detect and to quantify single pathogens in the complex biofilm formation on an antibacterial dental material. …”
Get full text

Use of Immunostimulants in Shrimp Farming—A Bioeconomic Perspective by Héctor Rodrigo Nolasco-Alzaga, Elizabeth Monreal-Escalante, Mariel Gullian-Klanian, Juan Antonio de Anda-Montañez, Antonio Luna-González, Fernando Aranceta, Marcelo E. Araneda-Padilla, Carlos Angulo

“…Immunostimulants have entered the industry to fight against diseases by enhancing the immune system and conferring better protection against pathogens. In this regard, dietary immunostimulants have been tested at the farm level, such as carbohydrates and proteins known to enhance immunity and improve survival rates under experimental conditions. …”
Get full text

Manufactured Yttrium Barium Copper Nano Oxide for Medicinal Applications by Rania Daha, Manel Bouloudenine, Katia Djenadi, Tarek Tahraoui, Stefano Bellucci, Abdelaziz Rabehi

“…This research sheds light on the potential of YBCO NPs as an antibacterial agent against specific pathogens. …”
Get full text

Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) by Shumyila Nasir, Muhammad Sufyan Vohra, Danish Gul, Umm E Swaiba, Maira Aleem, Khalid Mehmood, Saadia Andleeb

“…The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), the chief etiological agent for a range of refractory infections, has rendered all β-lactams ineffective against it. …”
Get full text