Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains by Elizaveta Anisimova, Dina Yarullina

“…These bacteria may function as vehicles of antibiotic resistance genes, which can be transferred to pathogenic bacteria. Therefore, monitoring and control of transmissible antibiotic resistance determinants in these microorganisms is necessary to approve their safety status. …”
Get full text

Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…Secondly, models show noncell autonomous signalling within the nervous system, offering the opportunity to develop our understanding of the way pathogenic signalling propagates, resembling Braak’s scheme of spreading pathology in PD. …”
Get full text

Enteropathogenic Bacterial and Intestinal Parasitic Infections among Asymptomatic Food Handlers in Rangsit University Canteens, Central Thailand by Sirima Kitvatanachai, Bajaree Jantrapanukorn, Utsanee Supcharoengoon, Chalirmporn Atasilp

“…The prevalence of enteropathogenic bacteria in stool cultures was 2.5%, and only Aeromonas spp. were detected. The pathogenic protozoa Giardia duodenalis was detected in 1.3% of samples, and nonpathogenic protozoa was found in 11.4%. …”
Get full text

Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer by Rizwan Romee, Jeffrey W. Leong, Todd A. Fehniger

“…Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. …”
Get full text

Genotypes and phenotypes of neurofibromatosis type 1 patients in Japan: A Hereditary Tumor Cohort Study by Mashu Futagawa, Tetsuya Okazaki, Eiji Nakata, Chika Fukano, Risa Osumi, Fumino Kato, Yusaku Urakawa, Hideki Yamamoto, Toshifumi Ozaki, Akira Hirasawa

“…We performed sequencing and copy number assays in a clinical laboratory and analyzed the clinical data of 44 patients with suspected NF1. Germline pathogenic variants were detected in 36 patients (81.8%), and 20.7% of the variants were novel. …”
Get full text

A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
Get full text

Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport by Yanqun Xu, Iftekhar Mahmood, Lilin Zhong, Pei Zhang, Evi B. Struble

“…Pregnant women are at high risk for infection by pathogens. Vertical transmission of infectious agents, such as Zika, hepatitis B, and cytomegalovirus during pregnancy, remains a public health problem, associated with dire outcomes for the neonate. …”
Get full text

The Role of Complement System in Septic Shock by Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang

“…This paper also discusses additional complement-related pathogenic mechanisms and intervention strategies for septic shock.…”
Get full text

Pasteurisation temperatures effectively inactivate influenza A viruses in milk by Jenna Schafers, Caroline J. Warren, Jiayun Yang, Junsen Zhang, Sarah J. Cole, Jayne Cooper, Karolina Drewek, B. Reddy Kolli, Natalie McGinn, Mehnaz Qureshi, Scott M. Reid, Thomas P. Peacock, Ian Brown, Joe James, Ashley C. Banyard, Munir Iqbal, Paul Digard, Edward Hutchinson

“…Abstract In late 2023 an H5N1 lineage of high pathogenicity avian influenza virus (HPAIV) began circulating in American dairy cattle Concerningly, high titres of virus were detected in cows’ milk, raising the concern that milk could be a route of human infection. …”
Get full text

Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. …”
Get full text

Multilocus Sequence Typing for Interpreting Blood Isolates of Staphylococcus epidermidis by Prannda Sharma, Ashley E. Satorius, Marika R. Raff, Adriana Rivera, Duane W. Newton, John G. Younger

“…Our data mirror previous studies examining the presence or absence of pathogenic genes in that the overlap between truly significant organisms and contaminants appears to prevent the use of MLST in the clarification of blood cultures recovering S. epidermidis.…”
Get full text

Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection by Zhou-Hua Cheng, Xi-Yan Luo, Sheng-Song Yu, Di Min, Shu-Xia Zhang, Xiao-Fan Li, Jie-Jie Chen, Dong-Feng Liu, Han-Qing Yu

“…Here, we report a universal one-pot fluorescent method for the detection of epidemic pathogens, delivering results within 15-20 min. This method uses heparin sodium to precisely tunes the cis-cleavage capability of Cas12 via interference with the Cas12a-crRNA binding process, thereby generating significant fluorescence due to the accumulation of isothermal amplification products. …”
Get full text

Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…This strategy provides an additional antiviral approach in the global effort against COVID-19 and may contribute to development of rapid responses against emerging pathogenic viruses.…”
Get full text

Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis by Annalisa Monaco, Ruggero Cattaneo, Maria Chiara Marci, Davide Pietropaoli, Eleonora Ortu

“…TMD may be classified into 4 groups: (a) TMD with Central Sensitization ULFTENS Responders; (b) TMD with Central Sensitization ULFTENS Nonresponders; (c) TMD without Central Sensitization ULFTENS Responders; (d) TMD without Central Sensitization ULFTENS Nonresponders. This pathogenic classification of TMD may help to differentiate therapy and aetiology.…”
Get full text

Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function by Pan Chen, Mujeeb Ur Rehman, Yanfeng He, Aoyun Li, Fuchun Jian, Longxian Zhang, Shucheng Huang

“…The intestinal barrier, which consists of chemical, mechanical, biological, and immune defences, plays a crucial role in protecting the host against pathogens, xenobiotics, and toxins present in the gastrointestinal tract. …”
Get full text

Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae by Dong Liu, Zhifu Chen, Yue Yuan, Haiming Jing, Jintao Zou, Xiaoli Zhang, Xi Zeng, Weijun Zhang, Quanming Zou, Jinyong Zhang

“…Innate immune effectors constitute the first line of host defense against pathogens. However, the roles of these effectors are not clearly defined during Klebsiella pneumoniae (K. pneumoniae) respiratory infection. …”
Get full text

The Missing LNK: Evolution from Cytosis to Chronic Myelomonocytic Leukemia in a Patient with Multiple Sclerosis and Germline SH2B3 Mutation by Krishna Gundabolu, Bhavana J. Dave, Carmelita J. Alvares, Jeffrey J. Cannatella, Vijaya R. Bhatt, Lori J. Maness, Zaid S. Al-Kadhimi, Rana K. Zabad, Allison M. Cushman-Vokoun

“…We outline the evidence supporting the pathogenic role of SH2B3 p.E395K germline mutation, connecting the dots of association between autoimmune diseases and CMML genesis.…”
Get full text

High power impulse magnetron sputtering deposited virucide and antibacterial CrN-Cu films and the durability of the antimicrobial activity by Santiago Domínguez-Meister, Janire Mediavilla, Anastasia Dianova, Noelia Álvarez, Sara Insausti, Edurne Rujas, Jose L. Nieva, Marta Brizuela, Iñigo Braceras

“…Surfaces loaded with microbes can contribute to the propagation of a wide variety of pathogens. In this work, the antimicrobial potential of a hard coating (CrN) doped with different proportions of a biocide element (copper) has been studied. …”
Get full text

Clinical and genetic analysis of a Chinese family with GM1 gangliosidosis caused by a novel mutation in GLB1 gene by Biao Zhang, Xiao-li Huang, Xin-xin Lu, Heng-bin Huang, Yan-an Wu

“…ObjectiveTo describe the clinical presentation and novel mutation in the ganglioside-beta-galactosidase gene (GLB1) gene in a Chinese family with GM1 gangliosidosis.MethodsWe collected clinical data from a Chinese family with GM1 gangliosidosis, and performed whole exon sequencing (WES) of the proband and his parents. The pathogenic sites of candidate genes were targeted, and the detected exon mutations were verified by Sanger sequencing. …”
Get full text

Mobilization of fruit, small fruit and nut crop genetic resources in Belarus by Z. A. Kazlouskaya, L. V. Fralova, A. A. Taranau, V. A. Yakimovich, I. G. Palubiatka

“…There are plans to use the obtained accessions in breeding practice assources of valuable agronomic traits (high winter hardiness, high yield, resistance to a set of plant pathogens, etc.).…”
Get full text