Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization by Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

“…Abstract The process of viral entry into host cells is crucial for the establishment of infection and the determination of viral pathogenicity. A comprehensive understanding of entry pathways is fundamental for the development of novel therapeutic strategies. …”
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Helicobacter pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance by Tiziana Larussa, Isabella Leone, Evelina Suraci, Maria Imeneo, Francesco Luzza

“…The presence of symptoms and their severity depend on bacterial components, host susceptibility, and environmental factors, which allow H. pylori to switch between commensalism and pathogenicity. H. pylori-driven interactions with the host immune system underlie the persistence of the infection in humans, since the bacterium is able to interfere with the activity of innate and adaptive immune cells, reducing the inflammatory response in its favour. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…These findings highlight a pathogenic mechanism stemming from the ASD-risk Shank3, emphasizing the significance of neonatal BECs in the BBB as a potential therapeutic target for ASD.…”
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Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent by V. A. Graham, G. J. Hatch, K. R. Bewley, K. Steeds, A. Lansley, S. R. Bate, S. G. P. Funnell

“…New vaccines against biodefense-related and emerging pathogens are being prepared for licensure using the US Federal Drug Administration’s “Animal Rule.” …”
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Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses by Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef

“…However, the importance of PADs, particularly PAD2, in the adaptive immune response, both normal and pathogenic, is newly emerging. In this study, we evaluated a requirement for PAD2 in the antibody response in collagen-induced arthritis (CIA), a T and B cell-driven murine model of rheumatoid arthritis, and in the protective antibody response to murine influenza infection. …”
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Three Unrelated Patients of Roma Ethnicity from a Single Center Carrying the Same Deletion in <i>MYD88</i> Gene: A Founder Effect? by Roberta Romano, Francesca Cillo, Laura Grilli, Alessio Ciaccio, Lorenzo Bufalo, Elisabetta Toriello, Antonio De Rosa, Carmen Rosano, Emilia Cirillo, Giancarlo Blasio, Marika Comegna, Carmela Di Domenico, Giuseppe Castaldo, Claudio Pignata, Giuliana Giardino

“…They underwent a comprehensive immunological work-up including targeted next-generation sequencing for IEIs that identified a homozygous pathogenic in-frame deletion c.157_159del p.(Glu53del) in <i>MYD88</i> gene, already described in this ethnic group, suggesting a founder effect. …”
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Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus by Lusha Cen, Fengling Xing, Liying Xu, Yi Cao

“…The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. …”
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Immortalized Schwann cell lines as useful tools for pathogenesis-based therapeutic approaches to diabetic peripheral neuropathy by Kazunori Sango, Hideji Yako, Hideji Yako, Naoko Niimi, Shizuka Takaku

“…Herein, recent studies with these cell lines regarding the pathogenic factors of DPN (augmentation of the polyol and other collateral glycolysis pathways, glycative and oxidative stress-induced cell injury, autophagic and proteostatic disturbances, etc.) and therapeutic strategies targeting these factors are introduced.…”
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Characterization of a Small Supernumerary Marker Chromosome Derived from Xq28 and 14q11.2 Detected Prenatally by Akihiro Hasegawa, Osamu Samura, Taisuke Sato, Tomona Matsuoka, Yuki Ito, Kazuhiro Kajiwara, Hiroaki Aoki, Yuka Inage, Masahisa Kobayashi, Aikou Okamoto

“…Our findings suggest that this sSMC is most likely pathogenic. The collection of additional cases may be required.…”
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Food Safety Challenges towards Safe, Healthy, and Nutritious Street Foods in Bangladesh by Md. Khairuzzaman, Fatema Moni Chowdhury, Sharmin Zaman, Arafat Al Mamun, Md. Latiful Bari

“…This may be partly attributed to improved surveillance, increased global trade and travel, changes in modern food production, the impact of modern lifestyles, changes in food consumption, and the emergence of new pathogens. Consumer’s knowledge and attitude may influence food safety behavior and practice. …”
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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Finally, using these structural, localization, and S1P transport results, we identify how pathogenic mutations ablate the protein’s export activity and thereby lead to hearing loss.…”
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Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss by Fengguo Zhang, Lei Xu, Yun Xiao, Jianfeng Li, Xiaohui Bai, Haibo Wang

“…They were concluded to be pathogenic mutations by phylogenetic analysis and structure modeling. …”
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Functional and Antimicrobial Properties of Propolis from Different Areas of Romania by Gianluca Albanese, Alexandru Ioan Giurgiu, Otilia Bobiș, Adriana Cristina Urcan, Sara Botezan, Victorița Bonta, Tudor Nicolas Ternar, Claudia Pașca, Massimo Iorizzo, Antonio De Cristofaro, Emilio Caprio, Daniel Severus Dezmirean

“…This substance plays a crucial role in the hive’s defence against a range of pathogenic agents, maintaining a consistent internal temperature and aseptic environment for the bee colony. …”
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Changes in glycosphingolipid levels in plasma and cerebrospinal fluid of individuals with Lysosomal Free Sialic Acid Storage Disorder by Marya S. Sabir, Lynne Wolfe, David R. Adams, Carla Ciccone, Forbes D. Porter, William A. Gahl, Marjan Huizing, Frances M. Platt, May Christine V. Malicdan

“…Lysosomal free sialic acid storage disorder (FSASD) is a rare, multisystem disease caused by biallelic pathogenic variants in SLC17A5, encoding the lysosomal transmembrane sialic acid exporter, sialin. …”
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Stray dogs as carriers of E. coli resistant strains for the retracted and re-emerged antibiotic colistin, based on the mcr-1 gene presence by Ioannis Tsakmakidis, Anastasia Parisi, Dimitrios K. Papadopoulos, Maria V. Alvanou, Konstantinos V. Papageorgiou, Evanthia Petridou, Ioannis A. Giantsis

“…Companion animals could have a role in human infection by pathogenic and resistant E. coli strains as they share the same environment and are in close contact with humans. …”
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Carbon nanodots from used green tea biochar: antibacterial applications and antibiofilm carbon coatings by E. Elsa Sharon, Jae-Wook Oh, Judy Gopal

“…The antibacterial activity was tested against pathogenic coliforms as well as oral bacteria. The results indicated that the indigenously prepared carbon nanodots exhibited significant antibacterial activity. …”
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Exploring RNA modifications in infectious non-coding circular RNAs by Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco di Serio, Beatriz Navarro, Hana Cahova

“…Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA. …”
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Research on Pork Jerky Obtained Through Fermentation with Pediococcus acidilactici by Zhao Xingxiu, Zhang Jing, Ming Hongmei, Zou Wei, Wang Yang, Zhao Changqing, Mu Shengdong, Zhang Hao, Qiu Lin

“…Furthermore, in the fermented pork jerky, the content of three acids (18.552%) was high, which lowered the pH of the pork jerky and inhibited growth of pathogens. Moreover, some new compounds produced, including 3-hydroxy-2-butanone (49.095%), 2,3-butanediol (2.790%), 2-ethyl-1-hexanol (2.400%), oxalic acid isobutyl hexyl ester (2.280%), phenylethyl alcohol (0.953%), and eucalyptol (0.659%), contributed to the flavour of pork jerky. …”
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Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites by Zeng Zhang, Yajing Fang, Yangli He, Mohamed A. Farag, Min Zeng, Yukai Sun, Siqi Peng, Shuaiming Jiang, Xian Zhang, Kaining Chen, Meng Xu, Zhe Han, Jiachao Zhang

“…Probio-M8 significantly improved muscle function in aged mice and enhanced physical performance in sarcopenia patients. It reduced pathogenic gut species and increased beneficial metabolites such as indole-3-lactic acid, acetoacetic acid, and creatine. …”
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