Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots by Dos Santos Delair Silveira, Oberger Júlia Vieira, Niero Rivaldo, Wagner Theodoro, Delle Monache Franco, Cruz Alexandre Bella, Martin-Quintal Zhelmy, Cechinel Filho Valdir

“…The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. …”
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Prevalence and Antibiotic Resistance Patterns of Ocular Bacterial Strains Isolated from Pediatric Patients in University Hospital of Campania “Luigi Vanvitelli,” Naples, Italy by Francesco Petrillo, Veronica Folliero, Biagio Santella, Gianluigi Franci, Francesco Foglia, Maria C. Trotta, Maria T. Della Rocca, Teresio Avitabile, Caterina Gagliano, Marilena Galdiero

“…The study aimed to evaluate the antimicrobial resistance profiles of the main pathogens involved in eye infections. This study involved pediatric patients enrolled at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2019. …”
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Dysphoric spectrum of emotional disorders at irritable bowel syndrome by M. A. Morozova, G. Ye. Rupchev, A. A. Alekseyev, A. G. Beniashvili, M. V. Mayevskaya, Ye. A. Poluektova, O. Z. Okhlobystina, V. T. Ivashkin

“…Somatic manifestations of IBS are associated to dysphoric experience indicating their potential pathogenic value. Imbalance between the scope of data on emotional disorders at IBS and the number of studies devoted to psychopharmacotherapy efficacy assessment at emotional disorders was revealed. …”
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Attempts to identify the molecular cause of autoinflammatory recurrent fever by Oksana Boyarchuk, Diana Savkiv

“…We present the molecular diagnosis results of 12 children with recurrent fever, analyzing the correlation between molecular findings and clinical symptoms. No pathogenic variants confirming autoinflammatory disease were found. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling. Taken together, our findings reveal a macrophage-specific ubiquitination signaling axis in colitis and CAC development and suggest that Pellino1 is a potential candidate for treating chronic inflammation and inflammation-related cancer.…”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
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Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…Along with traditional concepts on the risk factors of atherosclerosis and cardio-vascular diseases development one should take into account data on the new pathogenic mechanisms for these diseases. According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
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Recent Advances in Biopesticide Research and Development with a Focus on Microbials [version 4; peer review: 3 approved, 1 approved with reservations] by Dennis Ndolo, Jing Ge, Debbie Muir, Lawrence Malinga, Kahsay Tadesse Mawcha

“…Biopesticides are pest control products derived from natural sources such as microbes, macro-organisms (insects and pathogens), plant extracts, and certain minerals. Many biopesticides are considered environmentally safe and can complement or substitute conventional chemical pesticides. …”
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Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry by Qingping Liang, Wei Zhou, Siyuan Peng, Ziyu Liang, Zhemin Liu, Changliang Zhu, Haijin Mou

“…Bacteriocins produced by LAB have attracted the attentions for application in the food industry as natural food bio-preservatives because of their antimicrobial activity against the food spoilage and pathogenic bacteria. With the increasing demands of consumers for more healthier food and investigations on natural food preservatives, the bioactivity of bacteriocins allows them to give the application values to the bacteriocin-producing LAB. …”
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Effectiveness of the California Mastitis Test (CMT), Reductase Test, and Alcohol Test for Dairy Cows Subclinical Mastitis Detection by Eriza Rosalina Rochmah, Dadik Raharjo, Sri Hidanah, Mustofa Helmi Effendi, Adiana Mutamsari Witaningrum, Sunaryo Hadi Warsito

“…Mastitis is an inflammation of the mammary glands caused by pathogenic bacteria Mastitis divided into 2 types, clinical mastitis which has symptoms of swelling and changes in the shape of the mammary gland, while subclinical mastitis does not indicate clear symptoms. …”
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Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…In silico analyses predicted low toxicity and potential enzyme inhibition, along with antiprotozoal properties, suggesting these compounds as candidates against protozoan pathogens. Molecular docking confirmed inhibitory potential against trypanothione reductase, supporting antiprotozoal activity. …”
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FRUIT DAMAGES CAUSED BY BROWN MARMORATED STINK BUGS IN APPLES AND QUINCES by Attila Keseru, Flavia-Andreea Andrecan, Horia Alexandru Pop, Mihai Buta, Orsolya Borsai

“…Feeding injuries also made both fruits more susceptible to secondary infections by pathogens, further reducing their marketability. These findings highlight the economic impact of H. halys on fruit production and emphasize the need for integrated pest management (IPM) strategies. …”
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How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). …”
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NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery by Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly Taylor, Liliana Brown, Tamika Samuel, Lanling Zou

“…The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (<i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa,</i> and <i>Enterobacter</i> species). …”
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Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention by Xutao Yang, Li Zhu, Hong Pan, Yi Yang

“…Finally, we explore current interventions aimed at preventing and attenuating renal impairment related to CPB, and presenting these measures from three perspectives: (1) avoiding CPB to eliminate the fundamental impact on renal function; (2) optimizing CPB by adjusting equipment parameters, optimizing surgical procedures, or using improved materials to mitigate kidney damage; (3) employing pharmacological or interventional measures targeting pathogenic factors.…”
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Essential Oils-Loaded Electrospun Biopolymers: A Future Perspective for Active Food Packaging by Shahla Ataei, Pedram Azari, Aziz Hassan, Belinda Pingguan-Murphy, Rosiyah Yahya, Farina Muhamad

“…EOs can inhibit the growth of superficial food pathogens, modify nutritious values without affecting the sensory qualities of food, and prolong the shelf life when used in food packaging as an active ingredient. …”
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<i>Pseudomonas aeruginosa pqs</i> Quorum Sensing Mediates Interaction with <i>Mycobacterium abscessus</i> In Vitro by Yun Long, Zhi Li, Menglu Li, Peiyi Lu, Yujia Deng, Pengyao Wu, Xue Li, Gangjian Qin, Jiamin Huang, Wenying Gao, Guobao Li, Tianyuan Jia, Liang Yang

“…<i>Pseudomonas aeruginosa</i> and <i>Mycobacterium abscessus</i> are opportunistic pathogens that cause severe infections in hospitals, and their co-infections are increasingly reported. …”
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Peripheral proteinopathy in neurodegenerative diseases by Bin Xu, Xia Lei, Ying Yang, Jiayi Yu, Jun Chen, Zhi Xu, Keqiang Ye, Jing Zhang

“…This review summarizes the distribution, transportation pathways, and pathogenic mechanisms of several neurodegenerative disease-related pathological proteins in the periphery, proposing that targeting these peripheral pathological proteins could be a promising strategy for preventing and managing neurological diseases.…”
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Effects of tissue type and season on the detection of regulated sugarcane viruses by high throughput sequencing by Stephen Bolus, Kate Wathen-Dunn, Samuel C. Grinstead, Xiaojun Hu, Martha Malapi, Dimitre Mollov

“…Abstract High throughput sequencing (HTS) can supplement and may replace diagnostic tests for plant pathogens. However, the methodology and processing of HTS data must first be optimized and standardized to ensure the sensitivity and repeatability of the results. …”
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In vivo regulation of the monocyte phenotype by Mycobacterium marinum and the ESX-1 type VII secretion system by Kristina Munke, Line Wulff, Julia Lienard, Fredric Carlsson, William W. Agace

“…Abstract Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. …”
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