Microsatellite instability and somatic gene variant profile in solid organ tumors by Ibrahim Halil Erdogdu, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Nesibe Kahraman-Cetin, Habibe Guler, Merve Turan, Ibrahim Meteoglu

“…The most frequently observed pathogenic variant in both MSI-H and MSS cancer patients was BLM exon 7 c.1544delA. …”
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Asymptomatic Bacteriuria among Pregnant Women in Addis Ababa, Ethiopia: Prevalence, Causal Agents, and Their Antimicrobial Susceptibility by Ketema Bizuwork, Haile Alemayehu, Girmay Medhin, Wondwossen Amogne, Tadesse Eguale

“…It also aimed to identify causal bacterial pathogens and to assess their antimicrobial susceptibility. …”
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A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and <i>Plasmodium</i> as a Combination Vaccine Candidate by Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan

“…Background: Noroviruses, which cause epidemic acute gastroenteritis, and <i>Plasmodium</i> parasites, which lead to malaria, are two infectious pathogens that pose threats to public health. The protruding (P) domain of norovirus VP1 and the αTSR domain of the circumsporozoite protein (CSP) of <i>Plasmodium</i> sporozoite are the glycan receptor-binding domains of the two pathogens for host cell attachment, making them excellent targets for vaccine development. …”
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Genome evolution following an ecological shift in nectar-dwelling Acinetobacter by Vivianna A. Sanchez, Tanya Renner, Lydia J. Baker, Tory A. Hendry

“…ABSTRACT The bacterial genus Acinetobacter includes species found in environmental habitats like soil and water, as well as taxa adapted to be host-associated or pathogenic. High genetic diversity may allow for this habitat flexibility, but the specific genes underlying switches between habitats are poorly understood. …”
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Camptocormia as a feature of Mc Ardle's disease: A case report by Mathilde Nicolas, Chloé Giret, Sybille Pellieux, Annick Toutain, Anne-Marie Bergemer-Fouquet, Pascal Laforêt, Loic Bouilleau, François Maillot

“…Glycogen storage disease type 5 (GSD) is an autosomal recessive metabolic myopathy caused by pathogenic variants in the PYGM gene. We report the case of a patient with typical exercise intolerance with a “second wind” phenomenon, associated with camptocormia which is not commonly recognized as a feature of the disease. …”
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Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study by Shaozhe Cai, Bingxia Ming, Cong Ye, Shengyan Lin, Peng Hu, Jungen Tang, Fang Zheng, Lingli Dong

“…These findings indicate potentially overlapped pathogenic mechanisms in these two diseases, which may help uncover new therapeutic targets to ameliorate disease progression.…”
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Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo by Mawethu Pascoe Bilibana, Marimuthu Citartan, Tzi Shien Yeoh, Timofey S. Rozhdestvensky, Thean-Hock Tang

“…It is also prophesied that aptamers can also serve more than as a decontaminant, probably as a tool to capture and kill hazardous elements, particularly pathogenic agents.…”
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Study on the pathogenesis of pathophysiological changes of burn systemic infection by Li Ao (Ngao), Huang Yuesheng, Yang Zongcheng

“…These suggested that TXA2/PGI2. imbalance promoting microaggregate and thrombus formation may be one of the pathogenic effects of toxic shock and MOF in burn patients.…”
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A Rare Interstitial Duplication of 8q22.1–8q24.3 Associated with Syndromic Bilateral Cleft Lip/Palate by Regina Ferreira Rezek, Ana Angélica Rodrigues Abbas, Juliana Forte Mazzeu, Siliana Maria Duarte Miranda, Cibele Velloso-Rodrigues

“…Chromosome microarray analysis evidenced a 49 Mb duplicated segment of chromosome 8q with no pathogenic imbalances on chromosome 22. Two siblings also carry the balanced translocation. …”
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Organ-based characterization of B cells in patients with systemic lupus erythematosus by Yunan Wang, Rui Zhao, Qian Liang, Shiwen Ni, Mei Yang, Liwei Qiu, Juan Ji, Zhifeng Gu, Chen Dong

“…Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. …”
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The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis by Athanasios Mavropoulos, Eirini I. Rigopoulou, Christos Liaskos, Dimitrios P. Bogdanos, Lazaros I. Sakkas

“…Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis. …”
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Regulation of Immune Function by Polyphenols by Sujuan Ding, Hongmei Jiang, Jun Fang

“…Polyphenols promote immunity to foreign pathogens via various pathways. Different immune cells express multiple types of polyphenol receptors that recognise and allow cellular uptake of polyphenols, which subsequently activate signalling pathways to initiate immune responses. …”
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Bilateral Glaucoma as Possible Additional Feature for PGAP3-Associated Hyperphosphatasia by Osama Obaid, Reem Batawi, Heba Alqurashi, Thana Ewis, Ahmad A. Obaid

“…Whole exome sequencing revealed a possible pathogenic variant of PGAP3 in a homozygous state (c.320C > T, p.Ser107Leu) which supported the diagnosis of HPRMS type-4. …”
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Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses by Lyubomir A. Dourmishev, Dimitrina V. Guleva, Ljubka G. Miteva

“…For decades, IVIGs have been administered for treatment of infectious diseases and immune deficiencies, since they contain natural antibodies that represent a first-line defense against pathogens. Today their indication has expanded, including the off-label therapy for a variety of autoimmune and inflammatory diseases. …”
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The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke by Nada H. Aljarba, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Mustafa M. Shokr, Marios Papadakis, Athanasios Alexiou, Mubarak Alruwaili, Mohammed Alrouji, Mohammed S. Alshammari, Gaber El-Saber Batiha

“…Many studies highlighted that AGEs serum levels are correlated with the incidence, pathogenicity, and severity of AIS. However, the relationship between AGEs and AIS is not elucidated completely. …”
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Dendritic Cells and Their Multiple Roles during Malaria Infection by Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin

“…In this way, DCs sense the presence of a myriad of pathogens, including Plasmodium spp., the causative agent of malaria. …”
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Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, T. L. Lapina, A. S. Trukhmanov, I. M. Kartavenko, V. A. Kiprianis, O. Z. Okhlobystina

“…It’s etiology includes genetic predisposition, bad habits, previous intestinal infections, psychosocial factors. The basic pathogenic factors may include HCl hypersecretion, stomach and duodenal dysmotility and visceral hypersensitivity. …”
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Vaccination ARN messager (ARNm), modèle de transition de la biologie fondamentale à la médecine by Sansonetti, Philippe J.

“…Years of “translational” research and development have culminated in the success of anti-Covid-19 mRNA vaccines and the promise of more to come against emerging pathogens. A new paradigm in vaccinology, enabling pandemics to be tackled as they emerge. …”
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Dual role of pyroptosis in liver diseases: mechanisms, implications, and therapeutic perspectives by Siyuan Yang, Yunyi Zou, Chunhua Zhong, Zuoqiong Zhou, Xiyang Peng, Changfa Tang

“…It facilitates the clearance of damaged hepatocytes, preventing secondary injury, and triggers immune responses to eliminate pathogens and damaged cells. Conversely, excessive pyroptosis intensifies inflammatory responses, exacerbates hepatocyte damage and promotes the activation and proliferation of hepatic stellate cells, accelerating liver fibrosis. …”
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Regulation of Dendritic Cell Function in Inflammation by André Said, Günther Weindl

“…During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. …”
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