Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…Over the last decade, countless in-silico methods have been developed to predict the pathogenicity of point mutations on resolved structures, but no studies have evaluated their capabilities on unresolved protein structures predicted by AF2. …”
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Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance by Adewale A. Amupitan, Adeyemi T. Adeyemo, Adefunke O. Amupitan, Temitope O. Obadare, Aaron O. Aboderin

“…Results: Aerobic blood cultures were conducted in a third of clinical sepsis cases (n = 601/1851), of which 114 (19.0%) were true positives, with a 2.2% contamination rate. Pathogens recovered included six priority blood pathogens reportable to WHO GLASS. …”
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homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

“…In this nationwide prospective cohort study, we leveraged a Tasso-SST based self-blood collection and stabilization tool (homeRNA) to profile detailed kinetics of the presymptomatic to convalescence host immunity to contemporaneous respiratory pathogens. Methods: We enrolled non-symptomatic adults with recent exposure to ARIs who subsequently tested negative (exposed-uninfected) or positive for respiratory pathogens. …”
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Molecular Detection of Antibiotic-Resistant Genes in Pseudomonas aeruginosa from Nonclinical Environment: Public Health Implications in Mthatha, Eastern Cape Province, South Africa by Mojisola Clara Hosu, Sandeep Vasaikar, Grace Emily Okuthe, Teke Apalata

“…Evaluation of resistant profiles and detection of antimicrobial-resistant genes of bacterial pathogens in the nonclinical milieu is imperative to assess the probable risk of dissemination of resistant genes in the environment. …”
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Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Computational analysis involved variant calling, curation, and classification using specialized tools and databases. Results Pathogenic variants were identified in 6 out of 22 individuals, equaling a diagnostic yield of 27.3% and comprising variants in BPTF, NAA15, SCN1A, TUBA1A and twice in CACNA1A. …”
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Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

“…Although previous studies have identified common risk factors between AS and HT, the specific etiology and pathogenic mechanisms underlying these associations remain unclear. …”
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Food-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology by Dongdong Guo, Chang Liu, Hongkang Zhu, Yuliang Cheng, Xiang Huo, Yahui Guo, He Qian

“…Organisms utilize several systems to coexist with symbiotic microbes, regulate them, and concurrently avoid, expel, or neutralize harmful pathogens. Similarly, food quality control systems allow organisms to absorb necessary nutrients while defending against low-quality or harmful components in food. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Recently, many researchers suggested that the periodontal pathogenic bacteria Fusobacterium (F.) nucleatum has the TLR4-associated strong activator of the colorectal inflammation and cancer. …”
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Environmental microbial communications in gram-positive and gram-negative bacteria by P. Srikanth, D. Sivakumar, J. Nouri

“…The larger part of quorum sensing recognizing inhibitor takes bacterial quorum sensing share identifying as the even-handed and simply blocks the larger part recognizing plan of pathogenic organisms, which can demolish the pathogenicity of microorganisms without applying explicit squeezing factor, and doesn't execute the regular organisms or then again intrude with their standard physiological activities. …”
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Major F plasmid clusters are linked with ColV and pUTI89-like marker genes in bloodstream isolates of Escherichia coli by Cameron J. Reid, Max L. Cummins, Steven P. Djordjevic

“…Abstract Background F plasmids are abundant in E. coli, carrying a variety of genetic cargo involved in fitness, pathogenicity, and antimicrobial resistance. ColV and pUTI89-like plasmids have drawn attention for their potential roles in various forms of extra-intestinal pathogenicity. …”
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Reproductive problems in water buffalo cows associated with non-diagnosed genital lepto- spirosis. Preliminary results by Rosaura Pérez-Gil

“…PCR using the marker G1-G2 revealed the presence of Leptospira DNA in 55.5% of uterus, ovary, and oviduct samples, and 44.4% of kidneys; and using the primer Internal 1 and 2 identified pathogenic Leptospira spp, in 55.5% of the uterus and kidney samples, 33.3% in ovaries and 66.6% oviduct. …”
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A bioinformatics approach for identifying the probable cause of the cross-interaction of antibodies to the antigenic protein HPV16 L1 with the HPV6 L1 protein by A. S. Stolbikov, R. K. Salyaev, N. I. Rekoslavskaya

“…In our opinion, the most likely reason for the cross-interaction of antibodies with antigens of different pathogenic HPV types is the similarity of their antigenic determinants. …”
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Detection of Vibrio harveyi using hemolysin primer in tiger shrimp Penaeus monodon by Irma Suriyani, Ince Ayu Khairana Kadriah, ilmiah Kuruseng

“…The rapid detection on Vibrio pathogenic for tiger shrimp PL should be conducted within three to 12 hours of exposure. …”
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A variant in GRN of Spanish origin presenting with heterogeneous phenotypes by M. Menéndez-González, A. García-Martínez, I. Fernández-Vega, A. Pitiot, V. Álvarez

“…Introduction: The variant c.1414-1G>T in the GRN gene has previously been reported as probably pathogenic in subjects of Hispanic origin in the American continent. …”
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Effects and function of citric acid on fermentation quality and microbial community in sugarcane tops silage with high and low water-soluble carbohydrate content by Qichao Gu, Jie Zhang, Bo Lin, Hao Ding, Qi Yan, Caixiang Wei, Yipei Yao, Ruizhanghui Wang, Caixia Zou

“…., Clostridium_sensu_stricto_12 and Paecilomyces) and animal pathogens, while amino acid metabolism was lower in high-WSC STS regardless of CA treatment. …”
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Therapeutic Values of Earthworm Species Extract from Azad Kashmir as Anticoagulant, Antibacterial, and Antioxidant Agents by Rozina Ghulam Mustafa, Andleeb Dr Saiqa, Jorge Domínguez, Madiha Jamil, Saira Manzoor, Samna Wazir, Bushra Shaheen, Asma Parveen, Rida Khan, Shaukat Ali, Nazish Mazhar Ali, Fatima Jalal, Sadaf Azad Raja

“…Results revealed that all earthworm extracts showed the inhibition of all tested bacterial pathogens except P. aeruginosa (1), P. aeruginosa (2), S. warneri, and L. curvatus. …”
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Efficacy of biocontrol agents against damping-off and Sclerotinia stem rot diseases and their role in eliciting defense in chickpea plants by Yaser H. El-Gammal, Salama A. S. El-Blasy, Neamat A. M. Khalifa, Shereen Abu El-Maaty, Sara B. H. Awaly

“…Biological control has proved to be an effective alternative for managing plant diseases. Results These pathogenic fungi were isolated from different governorates in Egypt and differed in terms of their pathogenicity on Giza 3 cv.…”
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Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

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Metabolites induced by citrus tristeza virus and ‘Candidatus Liberibacter asiaticus’ influence the feeding behavior of Diaphorina citri: an electrical penetration graph and LC–MS/M... by Jingtian Zhang, Fengchun Xia, Yuhe Li, Yangyang Liu, Fengnian Wu, Xiaoling Deng, Meirong Xu

“…Abstract Citrus Huanglongbing and Citrus tristeza are two diseases that affect the citrus industry worldwide. The pathogens causing these diseases are the phloem-limited bacteria ‘Candidatus Liberibacter spp.’ …”
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Assessing tick attachments to humans with citizen science data: spatio-temporal mapping in Switzerland from 2015 to 2021 using spatialMaxent by Lisa Bald, Nils Ratnaweera, Tomislav Hengl, Patrick Laube, Jürg Grunder, Werner Tischhauser, Netra Bhandari, Dirk Zeuss

“…Abstract Background Ticks are the primary vectors of numerous zoonotic pathogens, transmitting more pathogens than any other blood-feeding arthropod. …”
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