Avian colibacillosis – current aspects by A. O. Gerasimova, O. B. Novikova, A. A. Savicheva

“…Colibacillosis is a bacterial disease of humans, animals and birds caused by Escherichia coli, pathogenic gram-negative bacillus. Despite its secondary nature, colibacillosis widely affects poultry farms and causes significant economic losses. …”
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Bacterial and Parasitic Assessment from Fingernails in Debre Markos, Northwest Ethiopia by Abeba Mengist, Yibeltal Aschale, Alemayehu Reta

“…Food handlers with untrimmed finger nails could contribute or serve as a vehicle for the transmission of food poisoning pathogens. Objectives. This study was conducted to determine the prevalence of bacteria and intestinal parasites among food handlers and antibiotic susceptibility profile of the isolated bacteria in Debre Markos University, Ethiopia. …”
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Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Ashish Shrestha, Shashi Keshwar, Toniya Raut

“…Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) are epithelial-derived pathologies which share inflammation as a common initial pathogenic-inducing state. Mast cell is a key immune modulating cell which is primarily involved in initiation and propagation of inflammation. …”
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Elevated Blood Urea Nitrogen-to-Serum Albumin Ratio as a Factor That Negatively Affects the Mortality of Patients with Hospital-Acquired Pneumonia by Ding-Yun Feng, Yu-Qi Zhou, Xiao-Ling Zou, Mi Zhou, Hai-Ling Yang, Xiao-Xia Chen, Tian-Tuo Zhang

“…This reported mortality identified by the univariate Cox regression analysis is found to have been affected by the following factors: age greater than 70 years, presence of diabetes mellitus and chronic obstructive pulmonary disease, gastric tube intubation, administration of proton-pump inhibitor, blood albumin level less than 30 g/l, elevated neutrophil-to-lymphocyte ratio, antibiotics therapy in the preceding 90 days, intensive care unit (ICU) admission, blood lymphocyte count less than 0.8 × 109/L, elevated blood urea nitrogen/albumin (BUN/ALB) level, and presence of multidrug-resistant (MDR) pathogens. In the second multivariate analysis, administration of proton-pump inhibitor, administration of antibiotics in the preceding 90 days, ICU admission, blood lymphocyte count less than 0.8 × 109/L, elevated BUN/ALB level, and presence of MDR pathogens were still associated with 30-day mortality. …”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Additionally, aggregation propensity, frustration analysis, and post-translational modification sites were analyzed for functional disruptions.ResultsOf the 184 substitutions analyzed, 50 were identified as deleterious, with 41 predicted to be pathogenic. Seventeen mutations were localized in the Calponin-homology (CH) 1 domain, a critical functional region of Dystrophin. …”
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The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…Sulfur metabolism is an essential aspect of fungal physiology and pathogenicity. Fungal sulfur metabolism comprises anabolic and catabolic routes that are not well conserved in mammals, therefore is considered a promising source of prospective novel antifungal targets. …”
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Revisiting the Synergistic In Vitro Antimicrobial and Antibiofilm Potential of Chlorhexidine Gluconate and Cetrimide in Combination as an Antiseptic and Disinfectant Agent by Diamond Jain, Rimjhim Gupta, Rashmi Mehta, Pratheesh N. Prabhakaran, Deva Kumari, Kulpreet Bhui, Deepa Murali

“…Overall, it can be inferred that the combination of chlorhexidine and cetrimide is a potential biocide that continues to be relevant for use in antisepsis and disinfection against infection-causing pathogens.…”
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Molecular genetic and bacteriological methods of bovine mycoplasmosis diagnosis by E. V. Remizova, A. V. Gorbatov, L. K. Semina, Z. A. Skulyabina, N. V. Shmidt, G. A. Baldicheva, N. N. Avduevskaya

“…They are most often detected in association with other pathogens, including those that can become L-forms if treated with antibiotics. …”
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Molecular characterization of feline caliciviruses isolated from several adult cats with atypical infection showing severe flu-like symptoms on a remote island in Ehime, Japan by Yuki Nishisaka, Hikaru Fujii, Fumiko Ono, Sho Kadekaru, Hiroyuki Kogiku, Yumi Une, Shione Takeguchi, Naomi Ohta, Masumi Eto, Chiharu Takeuchi, Seigou Takeuchi, Tetsuko Miki, Akihiko Tokuda, Keiko Ookawa, Yukinobu Tohya, Keita Ishijima, Akiko Okutani, Ken Maeda, Shumpei Watanabe, Shigeru Morikawa

“…The Aoshima strains isolated in the initial outbreak before December 5, 2020, and those isolated after the end of the outbreak, which are suspected pathogenic and typical non-pathogenic strains, respectively, were located in the same cluster and shown to be very similar in sequence. …”
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Trio-based whole-exome sequencing reveals mutations in early-onset high myopia by Ding Chen, Xiu-Feng Huang, Juan Huang, Yi-Ming Guo, Junhan Wei, Lu Ye, Yi-Xin Cai, Jiejing Bi, Fen-Fen Li

“…Pathogenic mutations were found in syndromic myopia genes, notably encompassing VPS13B, TRPM1, RPGR, NYX and RP2. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…To further elucidate the pathogenic mechanism basis of ARV p17 protein function, we employed a yeast two-hybrid system to identify Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as an interacting host protein with p17. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…Median age at diagnosis was 8 years (range 2–12). Three pathogenic variants (c.1006C>T, c.785C>T and c.19del) and two likely pathogenic variants (c.869C>T, c.772G>A) in CBS gene were identified. …”
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Multiplex one-step RT‒qPCR assays for simultaneous detection of AMDV, MEV and CDV by Zhi Cao, Hang Xu, Xinru Zhao, Ke Zhang, Dehua Yin, Shuai Ma, Wenling Li, Siyu Li, Jianwei Ren, Jianxin Wen

“…Results The results showed that the established method can not cross-react with other mink pathogens, with a detection sensitivity of 25 copies/µL and a coefficient of variation less than 3.51%. …”
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Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies by Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel, Shahaf Sigal‐Dror, Tali Ben‐Zur, Tamar Ziv, Daniel Offen, Shiri Zayit‐Soudry

“…Therefore, targeting a broad array of pathogenic processes holds promise for therapeutic intervention in AMD‐associated retinal pathology. …”
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Development of High Dietary Fiber Cereal Bar as Emergency Food Product and The Chemical-Microbiological Properties and Nutritional Content by Ani Radiati, Sumarto Sumarto, Fahmi Hafid, Emma Kamelia, Lia Nurcahyani, Dini Mariani, Siti Badriah, Tjahja Muhandri

“…Microbiological tests confirmed that the product was safe from pathogenic microbes, with total plate count (TPC) and Enterobacteriaceae  within safe limits. …”
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Coexistence of blaMIR-1 and blaNDM-1 resistance genes with a novel ST type in Enterobacter roggenkampii from a stool sample: A genome sequencing study by Qin Wang, Sayyed Salman, Ye Luo, XiaoMei Tong

“…Additionally, the genome harbours three antibiotic resistance genes and a newly discovered plasmid, pL3897_NDM, highlighting the need for surveillance of drug-resistant pathogens. Conclusions: The discovery of a new sequence type and the presence of an antibiotic resistance gene in E. roggenkampii L3897 underscores the need for ongoing genomic surveillance to effectively manage multidrug-resistant pathogens.…”
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Identification of TMPRSS3 as a Significant Contributor to Autosomal Recessive Hearing Loss in the Chinese Population by Xue Gao, Sha-Sha Huang, Yong-Yi Yuan, Jin-Cao Xu, Ping Gu, Dan Bai, Dong-Yang Kang, Ming-Yu Han, Guo-Jian Wang, Mei-Guang Zhang, Jia Li, Pu Dai

“…In our previous study, three pathogenic mutations in TMPRSS3 were identified in one Chinese family. …”
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Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC by Dakshinya M, Anitha P, A.S. Smiline Girija, Paramasivam A, Vijayashree Priyadharsini J

“…Background: Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. Periodontogenic pathogens such as Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans are the important pathogens associated with periodontitis. …”
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Isolation, genetic, and biological characterization of human adenovirus type 55 positive isolates from Wuhan, China by Jing Xie, Yan Wang, Huan Li, Bingxiu Tan, Zhengying Yu, Lizhong Li, Wei Zhang, Hongbin Song, Leili Jia

“…Infections by HAdV-55, one of the important pathogens leading to respiratory tract infections, often develop into pneumonia and are frequently associated with outbreaks in military camps and schools. …”
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Electronic Vaping-Induced Methicillin-Sensitive Staphylococcus Aureus Pneumonia and Empyema by Sachin M. Patil, Phillip Paul Beck, Tarang Pankaj Patel, Richard Dale Swaney, Dima Dandachi, Armin Krvavac

“…Pneumonia is a severe acute inflammation of the lower respiratory tract due to infectious pathogens. Pathogens responsible include bacteria, viruses, fungi, and parasites. …”
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