Isolation of a Novel Caprine <i>Eimeria christenseni</i> Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infect... by Emilio Barba, José Manuel Molina, Francisco Rodríguez, Otilia Ferrer, María Carmen Muñoz, Liliana M. R. Silva, María Cristina Del Río, José Adrián Molina, Anja Taubert, Carlos Hermosilla, Antonio Ruiz

“…<i>Eimeria christenseni</i> is considered among the most pathogenic <i>Eimeria</i> species in goats. The aim of this study was to isolate an <i>E. christenseni</i> strain and to assess its infectivity, pathogenicity, and ability to develop a protective immune response. …”
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Phytochemical and Antioxidant Dynamics of the Soursop Fruit (Annona muricata L.) in response to Colletotrichum spp. by Alejandro Rubio-Melgarejo, Rosendo Balois-Morales, Yolotzin Apatzingan Palomino-Hermosillo, Graciela Guadalupe López-Guzmán, José Carmen Ramírez-Ramírez, Edwin Cervantes-García, Brandon Javier Villalobos-Rosario, Pedro Ulises Bautista-Rosales

“…This work evaluates the effect of the pathogens Colletotrichum siamense and C. gloeosporioides on the response of soursop fruits. …”
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Wilson disease (novel ATP7B variants) with concomitant FLNC-related cardiomyopathy by Takeshi Imai, Satomi Mitsuhashi, Kenji Isahaya, Soichiro Shibata, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, NCBN Controls WGS Consortium, Yoshihisa Yamano

“…Abstract We report a case of Wilson disease (WD) with dilated cardiomyopathy in which whole-genome sequencing (WGS) revealed the rare co-occurrence of two novel compound heterozygous ATP7B pathogenic variants (NM_001005918.3:c.2250del/p.N751Tfs*9 and c.3496C>T/p.L1166F) and a known FLNC pathogenic variant. …”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…Abstract Background Current research underscores the need to better understand the pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). …”
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Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with He... by Ning Pan, Jie Qiu, Hang Sun, Fengqin Miao, Qian Shi, Jinhuan Xu, Wei Jiang, Hui Jin, Wei Xie, Youji He, Jianqiong Zhang

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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1 by Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran

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Vaginal Microbiota and the Use of Probiotics by Sarah Cribby, Michelle Taylor, Gregor Reid

“…This can lead to infection or to a state in which organisms with pathogenic potential coexist with other commensals. …”
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Molecular genetic analysis of Rubinstein–Taybi syndrome in Russian patients by Olga R. Ismagilova, Tagui A. Adyan, Tagui A. Adyan, Tatiana S. Beskorovainaya, Alexander V. Polyakov

“…Nevertheless, for approximately half of the patients in various cohorts, the diagnosis cannot be confirmed.MethodsIn this paper we present the results of a study of 158 Russian patients referred for molecular diagnosis of RSTS using multiplex ligation-dependent probe amplification (MLPA) and next-generation sequencing (NGS).ResultsPathogenic and likely pathogenic variants were identified in 67 patients (42.4%), of which 62 (39%) were in CREBBP and 4 cases (2%)—in EP300. …”
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GJB6-D13S1830 and GJB6-D13S1854 Deletions in Patients with non-Syndromic Prelingual Deafness by Mercedes Arceo Álvarez, Estela Morales Peralta, Yuledmi Perdomo Chacón, Teresa Collazo Mesa

“…These deletions have been found associated with pathogenic variants of the GJB2 gene in individuals with hearing loss. …”
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Phytosanitary monitoring of the narrow-leaved lupine collection of VIR in the northwest of Russia by R. A. Abdullaev, M. A. Vishnyakova, G. P. Egorova, E. E. Radchenko

“…Narrow-leaved lupine accessions with weak degrees of pathogenic damage were selected.…”
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The Antibacterial Activities of Secondary Metabolites Derived from Streptomyces sp. by Rabia Mrehil Elsalam, Khang Wen Goh, Mahani Mahadi, Najwa Mohammad, Yaman Walid Kassab, Noraziah Mohamad Zin, Kok-Yong Chin

“… The spreading of infectious diseases caused by the emergence of Multidrug-Resistant (MDR) pathogens is a global threat that has led to numerous deaths annually. …”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…When the microbial homeostasis in the periodontium is disrupted, pathogens within the biofilm can cause periodontitis and peri-implantitis, inducing host immune responses. …”
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A novel NFKB1 variant in a Japanese pedigree with common variable immunodeficiency by Naoko Nakatani, Akihiro Tamura, Hiroaki Hanafusa, Nanako Nino, Nobuyuki Yamamoto, Hiroyuki Awano, Yasuhiro Tanaka, Naoya Morisada, Suguru Uemura, Atsuro Saito, Daiichiro Hasegawa, Kandai Nozu, Yoshiyuki Kosaka

“…Her mother and daughter carried the same variant, demonstrating the first Japanese pedigree with an NFKB1 pathogenic variant.…”
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Anticariogenic Potential of Tabernaemontana Divaricata by Mini K. John, David Z. Cheriyan

“…Aims: To evaluate the antibacterial potential of T. divaricata against common caries pathogens like S. mutans and L. acidophilus. Settings and Design: Research is done in Biogenix Research Lab, Thiruvananthapuram. …”
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Antimicrobial Activities of Stigmasterol from Piper crocatum In Vitro and In Silico by Seftiana Lestari, Dikdik Kurnia, Tri Mayanti, Leny Heliawati

“…Therefore, it can be inferred that the stigmasterol present in Red Betel leaves could potentially function as an antimicrobial agent by impeding the spread of pathogenic oral microorganisms.…”
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Interpreting Variants of Uncertain Significance in PCD: Abnormal Splicing Caused by a Missense Variant of DNAAF3 by Haixia Zheng, Chongsheng Cheng, Miao He, Wangji Zhou, Yixuan Li, Jinrong Dai, Ting Zhang, Kai‐Feng Xu, Xue Zhang, Xinlun Tian, Yaping Liu

“…Methods Whole exome sequencing (WES) and Sanger sequencing were conducted to identify potential pathogenic variants of PCD. Minigene assays were performed to evaluate the pathogenicity of variants. …”
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Xanthomonas citri subsp. citri requires a genus-specific outer membrane protein and TolB to coordinate cell membrane integrity and virulence by Leilei Wu, Xueyan Zhu, Hang Long, Xinyu Huang, Shuying Zhu, Qi Xue, Ziao Li, Huasong Zou

“…The overall results support that OMPXan and TolB coordinate multi-faceted mechanisms to manage environmental stress and pathogenicity.…”
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Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions by Carlotta Costa, Giulia Germena, Emilio Hirsch

“…Phagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathogens. …”
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The Effects of Cold-Plasma Technology on the Quality Properties of Fresh-Cut Produce: A Review by Yuanpeng Li, Xinmeng Huang, Yuting Yang, Ailikemu Mulati, Jingyang Hong, Jiayi Wang

“…The development of the fresh-cut industry has been hindered by pathogenic contamination and quality deterioration. …”
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Detection of gene mutation in a case of Nagashima-type palmoplantar keratoderma by CAO Yuanyuan, YUAN Zhaojun, JIN Chuanyang, WANG Tianzi, LIAO Xiaojie, LIU Hong

“…[Objective] To report a case of Nagashima-type palmoplantar keratoderma (NPPK), identify pathogenic gene, and assist clinical diagnosis and classification of this disease. …”
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