High Glucose Aggravates the Detrimental Effects of Pancreatic Stellate Cells on Beta-Cell Function by Min Zha, Wei Xu, Qing Zhai, Fengfei Li, Bijun Chen, Zilin Sun

Get full text

Indigenous primary culture protocols for human adult skin fibroblast, pancreatic stellate cells, and peritoneal fibroblasts by Supriya Sharma, Gaurav Pande, Mohit Kumar Rai, Vikas Agarwal

Subjects: Get full text

Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression by Jinjun Qiu, Peng Zhu, Peng Zhu, Xing Shi, Jinquan Xia, Shaowei Dong, Liqun Chen

“…Expression of this gene panel was strongly associated with the activation of pancreatic stellate cells (PSCs), suggesting a unique T2D-specific signature characterized by COL1A2hi/VCANhi/SULF1hi PSCs. …”
Get full text

The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells by Y. Chong, S. Samsudin, D. Bahrani, C. Chang, A. Masamune, S. Ng, N. Ismail, K. Ho

Subjects: Get full text

Differentiation Potential of Pancreatic Fibroblastoid Cells/Stellate Cells: Effects of Peroxisome Proliferator-Activated Receptor Gamma Ligands by M.-L. Kruse, S. Hopf-Jensen, C. Timke, B. Agricola, G. Sparmann, A. Schmid, B. Sipos, A. Arlt, H. Schäfer

“…Pancreatic stellate cells have been investigated mostly for their activation process, supposed to support the development of pancreatic disease. …”
Get full text

Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

“…In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), PDAC and mismatch repair-deficient colorectal cancer (MRD CRC). …”
Get full text

Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…Here, we tested the efficacy of our novel H84T CAR in models of pancreatic ductal adenocarcinoma (PDAC), intractable tumors with aberrant glycosylation and characterized by desmoplastic stroma largely contributed by pancreatic stellate cells (PSCs).Methods We transduced human T cells with a second-generation retroviral construct expressing the H84T BanLec chimeric receptor, measured T-cell expansion, characterized T-cell phenotype, and tested their efficacy against PDAC tumor cells lines by flow cytometry quantification. …”
Get full text