The burden and temporal trend of early onset pancreatic cancer based on the GBD 2021 by Zongbiao Tan, Yang Meng, Yanrui Wu, Junhai Zhen, Haodong He, Yu Pu, Jixiang Zhang, Weiguo Dong

“…Abstract In the context of the global increase in early-onset tumours, investigating the global disease burden caused by early-onset pancreatic cancer (EOPC) is imperative. Data on the burden of EOPC were obtained from the Global Burden of Disease Study 2021. …”
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Folded and Unfolded Conformations of Proteins Involved in Pancreatic Cancer: a Layman's Guide by Jerónimo Bravo, José L. Neira

“…Pancreatic cancer (PC) is one of the most difficult illnesses to treat, since the 5-year survival rate is lower than 5% in patients and no substantial advances in its treatment have been achieved in the last 20 years. …”
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Protocol for generating a pancreatic cancer organoid associated with heterogeneous tumor microenvironment by Kenta Takeuchi, Shunsuke Tabe, Yuya Yamamoto, Kenta Takahashi, Megumi Matsuo, Yasuharu Ueno, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi

“…We present a protocol for generating a fused pancreatic cancer organoid (FPCO) that partly reproduces the TME, including heterogeneous cancer-associated fibroblasts (CAFs), using patient-derived PDAC cells and human-induced pluripotent cell-derived endothelial and mesenchymal cells. …”
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Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

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Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment by Yanyan Zhang, Zhichao Yang, Yuchen Liu, Jinjin Pei, Ruojie Li, Yanhui Yang

“…Abstract Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. …”
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Identification of ferroptosis-related signature predicting prognosis and therapeutic responses in pancreatic cancer by Ting Ting Chung, Zanyue Piao, Seung Jin Lee

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RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis by Xinqing Wang, Hao Fan, Xiaoping Ye, Yu Hu, Yan Xiao, Ming Zhang, Yonghui Xu, Jianjun Song, Yongyun Luo

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Sarcopenia as a Prognostic Factor of Hepatotoxicity and Lower Survival Rate in Chemotherapy of Pancreatic Cancer by A. A. Klunichenko, A. P. Seryakov, A. A. Seryakova, S. M. Demidov

Subjects: “…pancreatic cancer…”
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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. …”
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Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments by Jia-Haur Chen, John Vincent Lim, Yih-Chih Hsu

Subjects: “…Pancreatic cancer…”
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Oncolytic influenza virus enhances killing effect of gemcitabine against pancreatic cancer cells by MENG Zihe, MENG Zihe, XU Yongru, DENG Zhaoda

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AHNAK2: a potential diagnostic biomarker for pancreatic cancer related to cellular motility by Mohamed Zardab, Barts Pancreas Tissue Bank, Richard P. Grose, Hemant M. Kocher

“…In gene panels developed for early diagnosis of pancreatic cancer, high AHNAK2 mRNA expression was one possible biomarker. …”
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The Utility of Repeat Endoscopic Ultrasound-Guided Fine Needle Aspiration for Suspected Pancreatic Cancer by Mark Nicaud, Wei Hou, Dennis Collins, Mihir S. Wagh, Shailendra Chauhan, Peter V. Draganov

“…The utility of repeat EUS in patients with suspicion for pancreatic cancer after non-diagnostic EUS-FNA study is not well established. …”
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CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53 by Hongqiang Gao, Ran Xie, Rong Huang, Chonglin Wang, Yue Wang, Dongdong Wang, Kaimin Liu, Conghui Yang, Qingxiong Yang, Long Chen

“…Pancreatic cancer is one of the most malignant gastrointestinal tumors, and it is of great significance to explore the molecular mechanism of its progression and find new biological therapeutic targets. …”
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Survival benefits of adjuvant chemotherapy after conversion surgery in patients with advanced pancreatic cancer by Yoon Suk Lee, Jang Won Lee, Hak Jun Kim, Jung Won Chun, Jong-Chan Lee, Dong Kee Jang, Jin-Hyeok Hwang, Young Ae Kim, Sang Myung Woo

“…BackgroundOncologic outcomes of conversion surgery for advanced pancreatic cancer (PC) have scarcely been reported. Therefore, this study aimed to investigate the outcomes of conversion surgery with preoperative treatment of FOLFIRINOX or gemcitabine with nab-paclitaxel (GnP) for patients with advanced PC including locally advanced or metastatic PC.MethodsUsing the National Health Insurance database between 2005 and 2020, we identified patients who underwent conversion surgery after chemotherapy with FOLFIRINOX or GnP for advanced PC. …”
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Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives by Jagienka Agata Włodyka, Urszula Zelik, Maria Przygoda, Wiktoria Domino, Gabriela Trestka, Sabina Adamczyk, Kamila Stępień, Joanna Śnieżna, Wojciech Florczak, Karol Dzwonnik, Jakub Dziewic

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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

Subjects: “…pancreatic cancer…”
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Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer by Athina Stravodimou, Gianluigi Mazzoccoli, Ioannis A. Voutsadakis

“…Pancreatic cancer is one of the most lethal forms of human cancer. …”
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Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9 by Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu, Xuqi Li

Subjects: “…Pancreatic cancer…”
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Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells. by Eiman Abdo, Mohammad A Ismail, Sabal Al Hadidi, Mairvat Al-Mrahleh, Tareq Saleh, Malik Zihlif, Nidaa A Ababneh

“…<h4>Background</h4>Hypoxia in tumor cells is linked to increased drug resistance and more aggressive behavior. In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosuppressive properties. …”
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