Micro–Positron Emission Tomography/Contrast-Enhanced Computed Tomography Imaging of Orthotopic Pancreatic Tumor–Bearing Mice Using the αβ Integrin Tracer Cu-Labeled Cyclam-RAFT-c(-... by Winn Aung, Zhao-Hui Jin, Takako Furukawa, Michael Claron, Didier Boturyn, Chizuru Sogawa, Atsushi B. Tsuji, Hidekatsu Wakizaka, Toshimitsu Fukumura, Yasuhisa Fujibayashi, Pascal Dumy, Tsuneo Saga

“…Varying degrees of α v β 3 integrin expression in several human pancreatic cancer cell lines were examined by flow cytometry and Western blotting. …”
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Neurotensin is a Versatile Modulator of In Vitro Human Pancreatic Ductal Adenocarcinoma Cell (PDAC) Migration by Tatjana Mijatovic, Philippe Gailly, Véronique Mathieu, Nancy De Nève, Paul Yeaton, Robert Kiss, Christine Decaestecker

“…Background: While the neurotensin (NT) roles in pancreatic cancer growth are well documented, its effects on pancreatic cancer cell migration have not been described. …”
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ppENK Gene Methylation Status in the Development of Pancreatic Carcinoma by Lixin Yang, Hong Yang, Jingnan Li, Jianyu Hao, Jiaming Qian

“…Methylated ppENK was detected in all the pancreatic cancer cell lines and was associated with loss of mRNA expression in the pancreatic carcinoma cell lines and normal pancreatic tissue. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

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Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma by Noha Said Helal, Sara Maher, Safia Samir, Hesham A. Elmeligy, Mohammed A. Aboul-Ezz, Tarek Aboushousha, Mona Moussa

“…The levels of SATB2 in serum show promise for the diagnosis and tumor invasion of pancreatic cancer.…”
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The effect between metabolic syndrome and life expectancy after cancer diagnosis: Catalan cohort study by Tomàs López-Jiménez, Oleguer Plana-Ripoll, Talita Duarte-Salles, Anna Palomar-Cros, Diana Puente

“…The lowest RLE for both sexes was in pancreatic cancer. The largest differences between 0 and ≥ 3 MS components were observed in non-Hodgkin lymphoma and the smallest in pancreatic cancer. …”
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Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model by Ming-Jen Chen, Tsang-En Wang, Shu-Jung Tsai, Ching-Chung Lin, Chia-Yuan Liu, Horng-Yuan Wang, Shou-Chuan Shih, Yu-Jen Chen

“…Twenty BALB/c nude mice generated by direct orthotopic injection of human pancreatic cancer PANC-1 cells were randomized to receive either a stock laboratory diet or a stock diet supplemented with glutamine. …”
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Number of Endoscopic Retrograde Cholangiopancreatography Procedures Required for Short Biliary Cannulation Time by Koichiro Mandai, Koji Uno, Yasutoshi Fujii, Takuji Kawamura, Kenjiro Yasuda

“…Our findings suggested that an ERCP experience of ≤300 procedures and malignant biliary stricture due to pancreatic cancer were associated with prolonged biliary cannulation time.…”
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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301) by Tomonori Araki, Yuki Sonoda, Mototsugu Shimokawa, Taiga Otsuka, Kohei Hayashi, Takuya Honda, Kazuhiko Nakao, Taro Shibuki, Junichi Nakazawa, Shiho Arima, Keisuke Miwa, Yoshinobu Okabe, Futa Koga, Yujiro Ueda, Yoshihito Kubotsu, Hozumi Shimokawa, Shigeyuki Takeshita, Azusa Komori, Kazuo Nishikawa, Satoshi Otsu, Ayumu Hosokawa, Hisanobu Oda, Tatsunori Sakai, Shuji Arita, Machiko Kawahira, Hiroki Taguchi, Kengo Tsuneyoshi, Yasunori Kawaguchi, Toshihiro Fujita, Takahiro Sakae, Tsuyoshi Shirakawa, Toshihiko Mizuta, Kenji Mitsugi

“…Abstract The relationship between nanoliposomal irinotecan/fluorouracil/leucovorin (NFF) treatment outcomes and neutropenia in patients with pancreatic cancer has not been thoroughly examined. Thus, we conducted a retrospective analysis of data from patients with pancreatic cancer who were treated with NFF to investigate this relationship. …”
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Comparative efficacy and safety of neoadjuvant radiotherapy for patients with borderline resectable, and locally advanced pancreatic ductal adenocarcinoma: a systematic review and... by Xin Wang, Dan Cao, Qingfeng Wang, Qiancheng Hu, Wanrui Lv

“…The objective of the present network meta-analysis (NMA) is to study and compare the efficacy and safety of neoadjuvant radiotherapy comprehensively using different doses in patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC).Methods and analysis Four electronic databases, including PubMed, EMBASE, Cochrane library and Web of science, will be searched thoroughly to identify relevant studies published from 2006 to October 2020. …”
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Tilia species (linden) exert anti-cancer effects on MIA PaCa-2 cells through the modulation of oxidative stress and inflammation by Gamze Yüksel, Yağmur Özhan, Dilara Güreşçi, Etil Güzelmeriç, Nisa Beril Şen, İpek Bedir, Onur Senol, Gizem Emre, Dilek Telci, Vilma Petrikaitė, Hande Sipahi

“…Overall, our results highlight a potential use for Tilia extracts, particularly T. rubra, in pancreatic cancer treatment by modulating cell death.…”
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Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California by Yen-Yi Juo, Melinda A. Maggard Gibbons, Erik Dutson, Anne Y. Lin, Jane Yanagawa, O. Joe Hines, Guido Eibl, Yijun Chen

“…The diagnosis of obesity (BMI > 30) was associated with a reduction in diagnosis age across all four cancer types: 3.25 ± 0.53 years for gastric cancer, 4.56 ± 0.18 years for colorectal cancer, 4.73 ± 0.73 years for esophageal cancer, and 5.35 ± 0.72 for pancreatic cancer. The diagnosis of morbid obesity (BMI > 40) was associated with a more pronounced reduction in the age of diagnosis: 5.48 ± 0.96 years for gastric cancer, 7.75 ± 0.30 years for colorectal cancer, 7.67 ± 1.26 years for esophageal cancer, and 8.19 ± 1.25 years for pancreatic cancer. …”
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Epidemiological trends in gastrointestinal cancers and risk factors across U.S. states from 2000 to 2021: a systematic analysis for the global burden of disease study 2021 by Jiahao Jiang, Zhiqin Xie, Qingbin Wang, Bingkun Wang, Rong Huang, Weikai Xu, Changzhen Shang, Yajin Chen

“…Mortality rates for pancreatic cancer due to high body-mass index and high fasting plasma glucose have increased across states and age groups. …”
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Comparison of the Effects of Alcohol and Phenol Used for Celiac Neurolysis with Endoscopic Ultrasound in Patients with Pancreas Cancer: Retrospective Analysis by Birzat Emre Gölboyu, Uğur Özgürbüz

“…We retrospectively analyzed the data of the EUS-guided celiac neurolysis procedures for pain management of patients with pancreatic cancer. Results: Patients in the alcohol group had lower pain scores. …”
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Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation by Neha Goel

“…A 71-year-old male with pancreatic cancer exhibited multiple hypopigmented patches on fundus examination, with corresponding transmission defects on fluorescein angiography and outer retinal and RPE loss on optical coherence tomography, confirming RPE loss as the predominant feature. …”
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Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904... by Makoto Ueno, Takuhiro Yamaguchi, Tempei Miyaji, Yosuke Uchitomi, Takuji Okusaka, Masafumi Ikeda, Maiko Fujimori, Ayako Sato, Sayaka Jinno, Masato Ozaka, Yukiko Takayama, Yoshiyuki Majima

“…A total of 20 oncologists, 200 patients with advanced pancreatic cancer and the patients’ caregivers are enrolled in this study as of the writing of this protocol report. …”
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Gastrointestinal Bleeding due to Pancreatic Disease-Related Portal Hypertension by Kexin Zheng, Xiaozhong Guo, Ji Feng, Zhaohui Bai, Xiaodong Shao, Fangfang Yi, Yongguo Zhang, Rui Zhang, Han Liu, Fernando Gomes Romeiro, Xingshun Qi

“…Three elderly patients (>60 years old) were diagnosed with pancreatic cancer, of whom one underwent laparoscopic radical distal pancreatectomy and splenectomy, one received chemotherapy, and another one chose conservative management due to multiple systemic metastases. …”
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Cancer of the Pancreas: The Best Image for Early Detection – CT, MRI, PET or US? by Anthony E Hanbidge

“…Pancreatic cancer has a poor prognosis, and the best chance for survival is to diagnose the tumour at an early stage. …”
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Incidence and risk of endocrine and metabolic abnormalities linked to PARP inhibitors in solid tumors: a meta-analysis by Shunlian Fu, Pingjin Zou, Zengyi Fang, Xinxiang Zhou, Junyang Chen, Cuicui Gong, Li Quan, Bing Lin, Qiu Chen, Jinyi Lang, Meihua Chen

“…Niraparib demonstrated an increased risk of any-grade hyperglycemia (OR = 2.15, 95% CI 1.28–3.62), with patients receiving PARPi for metastatic pancreatic cancer showing a higher susceptibility to any-grade hyperglycemia (OR = 1.78, 95% CI 1.04–3.04). …”
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The power of personas: Exploring an innovative model for understanding stakeholder perspectives in an oncology learning health network by Dylan J. Cooper, Jessie Karten, Sarah E. Hoffe, Daniel A. King, Matthew Weiss, Danielle K. DePeralta, Andrew L. Coveler, Sunil R. Hingorani, Tracey Shefter, Cheryl Meguid, Hannah Roberts, Theodore S. Hong, Amol Narang, Amy Hacker‐Prietz, George A. Fisher, Jay Sandler, Laurie Singer, Bobby Korah, William Hoos, Carrie T. Stricker, Joseph M. Herman

“…Results Thirty‐one stakeholders from all facets of pancreatic cancer care were interviewed, including 20 care team members, 8 patients, and 3 caregivers. …”
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