Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models by Long Cheng, Xiang-bao Meng, Shan Lu, Ting-ting Wang, Yue Liu, Gui-bo Sun, Xiao-bo Sun

“…Taken together, our results show that TNTL exerted a strong hypoglycemic effect in two diabetic rodent animal models, preserving β-cells in the pancreas islet and reducing the risk of diabetic retinopathy and nephropathy.…”
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Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges by Ling-ling Pian, Ling-ling Pian, Mei-hui Song, Teng-fei Wang, Teng-fei Wang, Ling Qi, Tie-li Peng, Ke-ping Xie

“…It is crucial to remove PanIN lesions to prevent the development of invasive PDAC, as PDAC spreads rapidly outside the pancreas. This review aims to provide the latest knowledge on PanIN risk, pathology, cellular origin, genetic susceptibility, and diagnosis, while identifying research gaps that require further investigation in this understudied area of precancerous lesions. …”
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Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice by Xin Wang, Weiye Xiu, Ye Han, Zhili Wang, Yu Luo, Yongqiang Ma

“…Interestingly, real time-polymerase chain reaction (RT-PCR) and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins, including 5’-AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase I (CPT1), and acetyl coenzyme A carboxylase (ACC) in the liver and AMPK, sirtuin 1 (Sirt1), peroxisome proliferator-activated receptorycoactivator-1 (PGC-1α), and uncoupling protein 2 (UCP2) in the pancreas. To have a hypoglycemic effect, SCP-80-I regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/ACC/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1α and AMPK/Sirt1/UCP2 signaling pathways. …”
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Diseño robusto de un observador de perturbaciones con saturaciones: Aplicación al control de regulación de la glucosa en pacientes con diabetes tipo 1 by Hussain Alazki, David Cortés-Vega, Pedro García

“…La diabetes mellitus tipo 1 requiere de un estricto control en la administración de insulina para evitar consecuencias graves derivadas de la hiperglucemia y la hipoglucemia. El concepto de páncreas artificial permite la automatización en el tratamiento de pacientes con esta enfermedad, sin embargo, requiere de algoritmos de control capaces de operar eficientemente para mantener la concentración de glucosa en la sangre en niveles apropiados. …”
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Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study by Du-Bois Asante, Emmanuel Effah-Yeboah, Precious Barnes, Heckel Amoabeng Abban, Elvis Ofori Ameyaw, Johnson Nyarko Boampong, Eric Gyamerah Ofori, Joseph Budu Dadzie

“…Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.…”
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Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? by Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jindrich Kopecky, Pavel Ryska, Jana Draganovicova, Petr Dvorak

“…The biopsy location was variable, with kidney biopsy performed in 77 cases (55.8%), and other localizations (retroperitoneum, peritoneal cavity, liver, pelvis, pleural space, lung, mediastinum, chest or abdominal wall, and pancreas) in 61 cases (44.2%). Results: As many as 288 biopsies (97.1%), yielded true-positive results, and 4 procedures (2.9%) yielded histologically false-negative results that required confirmation through extended rebiopsy. …”
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Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics by James Wang, Jai Woong Seo, Aris J. Kare, Martin Schneider, Mallesh Pandrala, Spencer K. Tumbale, Marina N. Raie, Gokce Engudar, Nisi Zhang, Yutong Guo, Xiaoxu Zhong, Sofia Ferreira, Bo Wu, Laura D. Attardi, Guillem Pratx, Andrei Iagaru, Ryan L. Brunsing, Gregory W. Charville, Walter G. Park, Katherine W. Ferrara

“…Claudin-4 expression increases ~16 fold in cancer as compared with normal pancreas, and tight junction localization confers low background for imaging in normal tissue. …”
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Determination of Mammalian Target of Rapamycin Hyperactivation as Prognostic Factor in Well-Differentiated Neuroendocrine Tumors by G. Lamberti, C. Ceccarelli, N. Brighi, I. Maggio, D. Santini, C. Mosconi, C. Ricci, G. Biasco, D. Campana

“…A retrospective study was conducted on data from patients with diagnosis of neuroendocrine tumor originated from pancreas (pNET) or gastrointestinal tract (stomach, appendix, and ileus; GI-NET) made between January 2003 and December 2004 and followed up at our institution. …”
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Polyphenolic Compounds in Fabaceous Plants with Antidiabetic Potential by Lucia Guerrero-Becerra, Sumiko Morimoto, Estefania Arrellano-Ordoñez, Angélica Morales-Miranda, Ramón G. Guevara-Gonzalez, Ana Angélica Feregrino-Pérez, Consuelo Lomas-Soria

“…Phenolic compounds, with their high antioxidant activity, have shown promising potential in insulin synthesis, secretion, and the functionality of the endocrine pancreas. This review provides valuable information on various leguminous plants with anti-diabetic properties, including antioxidant, hypoglycemic, anti-fat-induced damage, and anti-apoptotic properties in vitro and in vivo, attributed to the high content of phenolic compounds in their seeds. …”
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab by Piotr Zielecki, Magdalena Kaniewska, Mariusz Furmanek, Tomasz Bulski, Grażyna Rydzewska

“…The highest ACE 2 expression was found in alveolar cells of the lungs [7], but also in the heart, kidneys, and gastrointestinal tract, including the pancreas. To date, it is not known if SARS-CoV-2 can cause pancreatic cell damage leading to acute pancreatitis, but in many cases serum lipase and amylase levels are elevated [8]. …”
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Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-Abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus by Manoj Kumar Sarma, Andres Saucedo, Suresh Anand Sadananthan, Christine Hema Darwin, Ely Richard Felker, Steve Raman, S. Sendhil Velan, Michael Albert Thomas

“…Correlation analyses indicated associations between IMCL U.I. and various metabolites in muscles with liver, pancreas, and abdominal fat estimates in T2DM. <b>Conclusions:</b> This study highlights distinct muscle metabolite and lipid composition patterns across YHC, AMHC, and T2DM subjects. …”
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Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia by Anastasia A. Zabolotneva, Katerina E. Popruga, Valentin V. Makarov, Sergei M. Yudin, Andrei M. Gaponov, Sergei A. Roumiantsev, Aleksandr V. Shestopalov

“…Results: According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in <i>ldlr</i>(−/−) mice, decreased serum glucose levels in <i>db</i>/<i>db</i> mice, improved lipid metabolism in <i>ldlr</i>(−/−) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. …”
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Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) by Liliana Ferreira, Edite Teixeira-de-Lemos, Filipa Pinto, Belmiro Parada, Cristina Mega, Helena Vala, Rui Pinto, Patrícia Garrido, José Sereno, Rosa Fernandes, Paulo Santos, Isabel Velada, Andreia Melo, Sara Nunes, Frederico Teixeira, Flávio Reis

“…Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. …”
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Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? by Ajami Gikandi, BA, Zhi Ven Fong, MD, MPH, DrPH, Motaz Qadan, MD, PhD, Raja R. Narayan, MD, MPH, Thinzar Lwin, MD, MS, Carlos Fernández-del Castillo, MD, Keith D. Lillemoe, MD, Cristina R. Ferrone, MD

“…Post-PD complication rates were not associated with long-term global QoL or functionality, and may be associated with less severe pancreas-specific symptoms.…”
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Clinical risk factors for sarcopenia in acute and chronic pancreatitis by Mitchell L. Ramsey, Andrew Lu, Kristyn Gumpper-Fedus, Stacey Culp, David Bradley, Darwin L. Conwell, Zobeida Cruz-Monserrate, J. Royce Groce, Samuel Han, Somashekar G. Krishna, Peter Lee, Thomas Mace, Georgios I. Papachristou, Kristen M. Roberts, Zarine K. Shah, Phil A. Hart

“…Methods A cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. TeraRecon software was used to calculate the cross-sectional area of skeletal muscle, visceral fat, and subcutaneous fat at the level of the L3 vertebrae. …”
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Impact of Age on Short- and Long-Term Outcomes after Pancreatoduodenectomy for Periampullary Neoplasms by Mario Gruppo, Francesca Tolin, Boris Franzato, Pierluigi Pilati, Ylenia Camilla Spolverato, Francesca Zingales, Imerio Angriman, Romeo Bardini

“…Methods. 124 consecutive patients who have undergone PD for pancreas neoplasms in our center between 2012 and 2017 were analyzed. …”
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Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation by Christopher Orr, Jeannette Stratton, Mohamed El-Shahawy, Elena Forouhar, Alice Peng, Gagandeep Singh, Keiko Omori, Meirigeng Qi, Fouad Kandeel

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4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis by Yu-pu Hong, Wen-yi Guo, Wei-xing Wang, Liang Zhao, Ming-wei Xiang, Fang-chao Mei, Ablikim Abliz, Peng Hu, Wen-hong Deng, Jia Yu

“…Results showed that 4-PBA attenuated the following: (1) pancreas and islet pathological injuries, (2) serum TNF-α and IL-1β, (3) serum insulin and glucose, (4) beta-cell ultrastructural changes, (5) ER stress markers (BiP, ORP150, and CHOP), Caspase-3, and insulin expression in islet. …”
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ELAVL1‐dependent SOAT2 exacerbated the pancreatitis‐like cellular injury of AR42J cells induced by hyperstimulation with caerulein by Yu‐Jing Sun, Hua‐Ying Chen, Xiao‐Qin Lai

“…Abstract Pancreatitis is a severe inflammatory condition characterized by damage to the pancreas. Sterol o‐acyltransferase 2 (SOAT2) has been reported to aggravate acute pancreatitis, however, the underlying mechanism remains to be elucidated. …”
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Benign Adrenocortical Tumors and the Detection of Nonadrenal Neoplasia by Meng Hao, Miguel Angel Luque-Fernandez, Diana Lopez, Kathryn Cote, Jessica Newfield, Molly Connors, Anand Vaidya

“…Cases were more likely to have detected intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (8.5% vs. 4.5%, adjusted OR = 2.22, 95% CI (1.11, 4.63)) compared with controls. …”
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