Investigating shared risk variants and genetic etiology between Alzheimer’s disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis by Weijia Dang, Tianqi Hao, Ning Li, Hualin Zhang, Ziqi Li, Hongmei Yu, Yalu Wen, Deqiang Zheng, Long Liu

“…Functional annotation and gene-set enrichment analysis indicated that 12 genes for comorbidity shared between patients with AD and all three stress-related psychiatric disorders were enriched in the spleen, pancreas, and whole blood.ConclusionThese results advance our knowledge of the shared genetic origins of comorbidities and pave the way for advancements in the diagnosis, management, and prevention of stress-related AD.…”
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Autoantibodies in type 1 diabetes: Prevalence and clinical profiles by Raja Hazime, Saad Lamjadli, Morad Guennouni, Mounir Belkrachni, Fatima-Ezzohra Eddehbi, Ider Oujamaa, Lahcen Elmoumou, Aicha Bourrahouate, Imane Ait Sab, Hicham Baizri, Nawal El Ansari, Brahim Admou

“…T1D is characterized by the destruction of insulin-producing beta cells in the pancreas, with the emergence of circulating autoantibodies (a-Abs) targeting β cell antigens. …”
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Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls by Niraj S. Patel, Michael R. Peterson, Grace Y. Lin, Ariel Feldstein, Bernd Schnabl, Ricki Bettencourt, Ekihiro Seki, Claude B. Sirlin, Rohit Loomba

“…Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. …”
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Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis by Nanako Kikuchi, Sae Hatanaka, Terufumi Kubo, Ryuta Kamekura, Masatoshi Kanda, Takuya Kakuki, Takashi Sasaya, Kengo Mita, Hiroki Kobayashi, Hajime Ikai, Kenta Sasaki, Naoki Shijubou, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Tadashi Hasegawa, Akihiro Miyazaki, Hiroki Takahashi, Ken-ichi Takano, Toshihiko Torigoe

“…It affects various organs, including the pancreas and salivary glands. Immunological abnormalities are suspected to play a role in its pathogenesis, and there is an epidemiological link to allergic conditions and type 2 inflammation. …”
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First Clinical Experience of ⁶⁸Ga-FAPI PET/CT in Tertiary Cancer Center: Identifying Pearls and Pitfalls by Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Ula Al-Rasheed, Dhuha Al-Adhami, Feras Istatieh, Farah Anwar, Marwah Abdulrahman, Rula Amarin, Issa Mohamad, Asem Mansour

“…<b>Methods:</b> A total of 48 patients with biopsy-confirmed solid tumors underwent 77 ⁶⁸Ga-FAPI PET/CT examinations for molecular imaging assessment, encompassing neoplasms originating from the gastrointestinal tract, head and neck, hepatobiliary system, pancreas, breast, and lung. <b>Results:</b> Notably, pancreaticobiliary tumors exhibited the highest tracer uptake, with mean maximum standardized uptake values (SUVmax) and tumor-to-background ratios (TBR) surpassing 10. …”
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Phytochemical Profile Screening and Selected Bioactivity of <i>Myrtus communis</i> Berries Extracts Obtained from Ultrasound-Assisted and Supercritical Fluid Extraction by Ilir Mërtiri, Gigi Coman, Mihaela Cotârlet, Mihaela Turturică, Nicoleta Balan, Gabriela Râpeanu, Nicoleta Stănciuc, Liliana Mihalcea

“…The antidiabetic potential was evaluated <i>in vitro</i> by measuring the inhibition of <i>α</i>-amylase from porcine pancreas (type I-A). The results highlighted the ability of myrtle berry extracts to inhibit <i>α</i>-amylase enzymatic activity, suggesting its potential as an alternative for controlling postprandial hyperglycemia. …”
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American Society for Gastrointestinal Endoscopy guideline on gastrostomy feeding tubes: methodology and review of evidence by Divyanshoo Rai Kohli, MD, Natalie Cosgrove, MD, Wasif M. Abidi, MD, PhD, Jorge D. Machicado, MD, MPH, Madhav Desai, MD, MPH, Nauzer Forbes, MD, MSc, Neil B. Marya, MD, Nikhil R. Thiruvengadam, MD, Nirav C. Thosani, MD, MHA, Omeed Alipour, MD, Saowanee Ngamruengphong, MD, Sherif E. Elhanafi, MD, Sunil G. Sheth, MD, Wenly Ruan, MD, John C. Fang, MD, Stephen A. McClave, MD, Rodrick C. Zvavanjanja, MD, MSc, FRCR(UK), FSIR, DABR(DR/VIR), Dhruvil K. Radadiya, MBBS, Amir Y. Kamel, PharmD, BCNSP, Bashar J. Qumseya, MD, MPH

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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Pathological and morphological analyses show that starting from posttreatment day 9, mice that received CP+DNA preparations displayed pronounced morphological changes in their lungs, liver, pancreas, central and peripheral immune system organs, and brain. …”
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Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis by Tian-Yong Han, Tao Cheng, Bo-Fu Liu, Ya-Rong He, Pan Pan, Wen-Tao Yang, Qiang-Lai, Yu Cao

“…Acute pancreatitis (AP) is a sudden inflammatory process in the pancreas with variable involvement of nearby organs or other organ systems, and it is a common cause for hospitalization of gastrointestinal origin. …”
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lncRNA-SNHG14 Plays a Role in Acute Lung Injury Induced by Lipopolysaccharide through Regulating Autophagy via miR-223-3p/Foxo3a by Jun Hong, Shijing Mo, Fangxiao Gong, Zongbin Lin, Hanhui Cai, Ziqiang Shao, Xianghong Yang, Renhua Sun, Qiangnu Zhang, Jingquan Liu

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Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism by A. P. Santos, J. Vinagre, P. Soares, I. Claro, A. C. Sanches, L. Gomes, I. Fernandes, A. L. Catarino, J. Preto, B. D. Pereira, A. P. Marques, F. Rodrigues, C. Amaral, G. Rocha, J. C. Mellidez, H. Simões, J. M. Lopes, M. J. Bugalho, On behalf of the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism

“…The most frequent primary sites were the pancreas (31.1%), jejunum-ileum (24.2%), stomach (13.7%), and rectum (8.5%). …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Findings: Neither lung, liver, pancreas or kidney damage nor massive necroptosis or cytokine storm could explain the lethality. …”
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Impact of antiviral prophylaxis on EBV viremia and posttransplant lymphoproliferative disorders in solid organ transplant recipients: a systematic review and meta-analysis by Marjan Moghadamnia, Khadijeh Delroba, Shima Heidari, Zahra Rezaie, Simin Dashti-Khavidaki

“…Antiviral prophylaxis significantly impacted the occurrence of PTLD events among kidney/simultaneous pancreas and kidney (RR 0.63, 95% CI 0.46 to 0.87) and heart (RR 0.61, 95% CI 0.39 to 0.96) transplant patients but not liver  (RR 0.5, 95% CI 0.23 to 1.08) transplant recipients.…”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…Results PRRG1 was significantly upregulated in PDAC compared to normal pancreas, correlating with poorer patient survival. …”
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