Clinical risk factors for sarcopenia in acute and chronic pancreatitis by Mitchell L. Ramsey, Andrew Lu, Kristyn Gumpper-Fedus, Stacey Culp, David Bradley, Darwin L. Conwell, Zobeida Cruz-Monserrate, J. Royce Groce, Samuel Han, Somashekar G. Krishna, Peter Lee, Thomas Mace, Georgios I. Papachristou, Kristen M. Roberts, Zarine K. Shah, Phil A. Hart

“…Methods A cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. TeraRecon software was used to calculate the cross-sectional area of skeletal muscle, visceral fat, and subcutaneous fat at the level of the L3 vertebrae. …”
Get full text

Impact of Age on Short- and Long-Term Outcomes after Pancreatoduodenectomy for Periampullary Neoplasms by Mario Gruppo, Francesca Tolin, Boris Franzato, Pierluigi Pilati, Ylenia Camilla Spolverato, Francesca Zingales, Imerio Angriman, Romeo Bardini

“…Methods. 124 consecutive patients who have undergone PD for pancreas neoplasms in our center between 2012 and 2017 were analyzed. …”
Get full text

4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis by Yu-pu Hong, Wen-yi Guo, Wei-xing Wang, Liang Zhao, Ming-wei Xiang, Fang-chao Mei, Ablikim Abliz, Peng Hu, Wen-hong Deng, Jia Yu

“…Results showed that 4-PBA attenuated the following: (1) pancreas and islet pathological injuries, (2) serum TNF-α and IL-1β, (3) serum insulin and glucose, (4) beta-cell ultrastructural changes, (5) ER stress markers (BiP, ORP150, and CHOP), Caspase-3, and insulin expression in islet. …”
Get full text

Benign Adrenocortical Tumors and the Detection of Nonadrenal Neoplasia by Meng Hao, Miguel Angel Luque-Fernandez, Diana Lopez, Kathryn Cote, Jessica Newfield, Molly Connors, Anand Vaidya

“…Cases were more likely to have detected intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (8.5% vs. 4.5%, adjusted OR = 2.22, 95% CI (1.11, 4.63)) compared with controls. …”
Get full text

Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…Results: In STZ-induced diabetic mice, treatment with (PTE+PSE)-NLC significantly improved pancreas and kidney health. It restored the kidney hypertrophy index, stabilized biochemical parameters, enhanced histopathological outcomes, and increased beta-cell count. …”
Get full text

IgG4 as a Biomarker in Graves’ Orbitopathy by Michał Olejarz, Ewelina Szczepanek-Parulska, Daniela Dadej, Nadia Sawicka-Gutaj, Remigiusz Domin, Marek Ruchała

“…It typically affects the pancreas, the salivary glands, and the retroperitoneal space. …”
Get full text

Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…We have previously demonstrated that the pancreas can recover from chronic pancreatitis (CP) lesions in the cerulein-induced mouse model. …”
Get full text

Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases by Erica S. Tsang, Jonathan M. Loree, Janine M. Davies, Sharlene Gill, David Liu, Stephen Ho, Daniel J. Renouf, Howard J. Lim, Hagen F. Kennecke

“…The primary location of the NET included pancreas (31%), small bowel (41%), large bowel (6%), unknown (14%), and others (12%). 69% of these patients had liver metastases alone, and tumors were graded as G1 (61%), G2 (25%), G3 (2%), and unknown (12%). …”
Get full text

Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…Here, we characterize the establishment and/or expansion of colorectal, lung, head and neck, breast, pancreas, and endometrial tumoroids using the standardized, serum-free Gibco OncoPro Tumoroid Culture Medium. …”
Get full text

miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms by Lukas Geisler, Katharina Detjen, Teresa Hellberg, Marlene Kohlhepp, Carsten Grötzinger, Jana Knorr, Ines Eichhorn, Raphael Mohr, Theresa Holtmann, Bertram Wiedenmann, Frank Tacke, Christoph Roderburg, Alexander Wree

“…Neuroendocrine neoplasms (NENs) are a diverse group originating from endocrine cells/their precursors in pancreas, small intestine, or lung. The key serum marker is chromogranin A (CgA). …”
Get full text

PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection by Hao Jiang, Jiwei Gu, Haiyang Zhao, Sumit Joshi, Joel S. Perlmutter, Robert J. Gropler, Robyn S. Klein, Tammie L. S. Benzinger, Zhude Tu

“…Ex vivo biodistribution data showed that the uptake of [18F]TZ4877 was increased 30.6%, 54.3%, 74.3%, and 115.3% in the liver, kidney, pancreas, and thymus of the infected mice, respectively, compared to that in normal control mice, indicating that S1PR1 is involved in the early immune response to bacterial infection. …”
Get full text

Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

“…Moreover, we show that through heterotopic implantations the site of tumor development defines the response to therapy, as implantation of HNSCC tumors into the pancreas resulted in comparable levels of tumor progression.Conclusions This work highlights the complexity of combining immunotherapies within the tumor microenvironment (TME) and further defines the immune and non-immune components of the TME as an intrinsic feature of immune suppression.…”
Get full text

Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…Glucose homeostasis parameters and islet area/pancreas area ratio improved, as compared to diabetic controls, when T1D mice were treated for three weeks with GABA and EMPA. …”
Get full text

Prevalence and characteristics of gastrointestinal disorders, medication use, and diagnostic interventions in pediatric patients with cystic fibrosis: a nested case–control analysi... by Carolena Trocchia, Carolena Trocchia, Maua Mosha, Bailey Hamner, Neil Goldenberg, Racha Khalaf

“…The prevalence of diseases of the biliary tract and pancreas (43% vs. <1%; p<.0001), hepatic disease (8.8% vs. …”
Get full text

A Morphological and Immunohistochemical Study of the Tumoral and Inflammatory Cells in Pancreatic Ductal Adenocarcinoma by Vlad Herlea, Elena Stoica Mustafa, Andreea Cristina Iorgescu, Nicolae Catalin Pechianu, Dragos Cretoiu, Maria Sajin, Simona Olimpia Dima, Catalin Vasilescu, Cezar Stroescu, Constantin Ungureanu, Traian Dumitrascu, Vladislav Brasoveanu, Minerva Ghinescu, Irinel Popescu

“…Patients presented with early stages (IA and IB), with low pathologic grade (G1), with small size tumors (less than 1-1.5 cm), with tumors located in the head of the pancreas, (p53: negative; p21: positive; and CD 68: positive in peritumoral tissue), with low nuclear index (Ki 67<10%), without metastases at the time of surgery (had a better prognosis), and with a survival rate of about 7 months. …”
Get full text

Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer by Georgia Porter, Murray D. Norris, Minoti Apte, Angelica M. Merlot

“…Results: BiP and CHOP were upregulated in CAFs and endothelial cells in PDAC sections relative to non-neoplastic pancreas sections. High BiP expression in CAFs and endothelial cells was associated with greater vascular invasion and in immune cells was correlated with increased tumor size. …”
Get full text

Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development by Han Koo, Kyung Chan Park, Hyun Ahm Sohn, Minho Kang, Dong Joon Kim, Zee-Yong Park, Sehoon Park, Sang Hyun Min, Seong-Hwan Park, Yeon-Mi You, Yohan Han, Bo-Kyung Kim, Chul-Ho Lee, Yeon-Soo Kim, Sang J. Chung, Young Il Yeom, Dong Chul Lee

“…In conditional KrasG12D knock-in mouse models of pancreatic ductal adenocarcinoma, Ndrg3 depletion abolishes Kras protein expression and suppresses intraepithelial neoplasia formation in pancreas. Mechanistically, KRAS protein binds to the C-terminal serine/threonine-rich region of NDRG3, subsequently going through deubiquitination by USP9X recruited to the complex. …”
Get full text

CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…CMV more commonly affects the retina, lungs, liver, and GI tract; however, in rare cases, it is known to affect the pancreas as well. Other more common causes of pancreatitis were ruled out during the progression of this patient, and an elevated lipase with high CMV viral load points towards CMV pancreatitis. …”
Get full text

Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

“…Autopsy revealed a marked organ infiltration with haemosiderin (heart, stomach, liver, pancreas, lungs, kidneys, adrenal glands).Conclusion. …”
Get full text

A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein by Juan José Valenzuela-Fuenzalida, Benjamín Rodríguez-Osorio, Cristian Salgado-Torres, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandro Bruna-Mejías, Roberto Avila-Sepulveda, Álvaro Becerra-Farfán, Macarena Rodríguez-Luengo, Juan Sanchis-Gimeno, Guinevere Granite, Héctor Gutiérrez-Espinoza

“…Abstract The hepatic portal vein is the main vascular route responsible for collecting blood from the liver, spleen, pancreas, stomach, gallbladder, and intestines. Its key function is to metabolize the components acquired from the blood. …”
Get full text