Genetic Variants in the SCN9A Gene are Detected in a Minority of Erythromelalgia Patients by Mari Skystad Kvernebo, Celene Grayson, Ioannis M. Stylianou, Virginia Woloshen, Christopher Radomski, Cato Mørk, Knut Kvernebo

“…Gain-of-function variants in the voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, have previously been identified in patients with erythromelalgia, a clinical diagnosis defined by intermittent attacks of painful, hot, swollen, and red skin, predominantly involving the hands and feet. …”
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Zinner syndrome unveiled: Ectopic ureter and seminal vesicle cyst leading to urinary dysfunction: A case report by Zaid Sawaftah, Khaled Sawafta, Moath Hattab, Adel Abu Al Rub, Omar Sawafta, Jehad Khamaysa, Humam Emad Rajha, Jana Dibas, Muath Daraghmeh, Yazan Dibas

“…This case report details the presentation and management of a 27-year-old male diagnosed with ZS following a 2-month history of urinary frequency, hesitancy, dysuria, and painful ejaculation. Physical examination revealed a left lower abdominal mass, and imaging confirmed the classic findings of ZS, including unilateral renal agenesis, an enlarged seminal vesicle cyst, and an ectopic ureter. …”
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Diagnostic Difficulties of Erosive Lichen Planus in a Pediatric Patient by Carolyn Szwed, Olivia Gudziewski, Marta Sar-Pomian, Malgorzata Olszewska, Lidia Rudnicka, Joanna Czuwara

“…<b>Case <b>Presentation</b>:</b> A 12-year-old boy presented with painful erosions and ulcers on the lateral tongue and dystrophic nails. …”
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Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation by Praveen K. Sharma, Iffath Misbah, J.H.Shazia Fathima, Ajay Lucas Rubben, Jeban Chella Bruce

“…Discussion: Mandibular osteosarcoma typically presents as a painless swelling or a painful mass in the jaw, often leading to a delayed diagnosis due to its nonspecific symptoms. …”
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Antibacterial potential of celery (Apium graveolens L.) extract gel against Staphylococcus aureus by Martinus Ezra Sunarno, Anita Lidesna Shinta Amat, Arley Sadra Telussa, Prisca Deviani Pakan

“… Background: Staphylococcus aureus can cause furuncles or boils, painful nodules on the skin. Conventional topical therapies often lead to side effects such as contact dermatitis and pruritus, compounded by the increasing problem of antibiotic resistance. …”
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Noise Level Identification on Dental Clinic by Izza Kamila, Vincentius Totok Noerwasito, Fx Teddy Badai Samodra

“…Noise can cause toothache to be more psychologically painful, which causes dryness of the oral cavity. …”
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A Case of Large Perianal Mucinous Adenocarcinoma Arising from Recurrent Abscess and Complex Fistulae by Fahmi Pramaditto Azmi, Nur Afdzillah Abdul Rahman, Luqman Mazlan, Normala Basiron, Farrah-Hani Imran

“…He presented with a 6-month history of a discharging growth in perianal region and painful defecation associated with occasional blood mixed stools. …”
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Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing by Barbro Lernmark, Kristian Lynch, Judith Baxter, Roswith Roth, Tuula Simell, Laura Smith, Ulrica Swartling, Suzanne Bennett Johnson, TEDDY Study Group

“…Results suggest that, for families of children genetically at risk for diabetes, procedures that can be painful/frightening should be used with caution. Study procedures must also be considered for the demands placed on participants. …”
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The Relevance of CD117-Immunocytochemistry Staining Patterns to Mutational Exon-11 in c-kit Detected by PCR from Fine-Needle Aspirated Canine Mast Cell Tumor Cells by A. Sailasuta, D. Ketpun, P. Piyaviriyakul, S. Theerawatanasirikul, P. Theewasutrakul, A. Rungsipipat

“…However, MCT diagnosis and prognosis are still dependent on histopathology which is rather inconvenient, time-consuming, painful, and harmful for some cases. Indeed, MCT can be easily accessible using fine-needle aspiration (FNA). …”
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A Rare Otological Presentation of Squamous Papilloma by Tanuj Madan, Sunil Goyal, Sachin Thongam

“…Case report: We present a case of EAC SP in a 15 year old girl hailing from north-eastern India who presented to us with a mass in the EAC which was acutely painful. Contrast Enhanced Computed Tomography remained the gold standard and imaging study of choice for evaluation. …”
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Plexiform Schwannoma of the Penis: A Rare Subtype of Genital Schwannoma by Chrysovalantis Gkekas, Vasileios Kalyvas, Evangelos N. Symeonidis, Apostolos Malioris, Michail Papathanasiou, Nikolaos Kalinderis, Kyriakos Moisidis, Konstantinos Hatzimouratidis

“…A 39-year-old patient presented to our andrology outpatient clinic complaining for two painful penile nodules. The lesions were located on the dorsum of the penile shaft. …”
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Retained multiple contact lenses in a vulnerable dementia patient by Rohit SHARMA, Zuhair SHARIF

“…We report a case of an 85-year-old female nursing home resident with a background of dementia, who pre- sented to the eye casualty clinic complaining of an 8-month history of a painful red eye and reduced vision. Treated ‘on and off ’ by various doctors and healthcare professionals with antibiotic drops for eight months with no improvement. …”
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A Case of Xanthoma of Bilateral Tendoachilles Reconstructed with Fascia Lata Graft X by S Jaikish, Balaji Sambandam

“…Gradually, it became painful while walking. On examination, she had a swelling of size 10 by 4 cm attached to tendoachilles. …”
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Simultaneous paratesticular liposarcomas with histopathological differences. A Case report by Pedro León Acosta, Pedro Rosales Torres

“…The purpose of this work is to present a case of simultaneous paratesticular liposarcomas with different histological types, in an 80-years-old male patient with a health history and low socioeconomic level; For two years he had been experiencing an increase in volume in the left inguinal region and ipsilateral testicle, which at first was painless; Then, as it increased in size, it became painful, covering the entire right inguinoscrotal region. …”
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Targeted Regulation Of Cgrp Gene Expression by A. F. Russo, P. L. Durham

“…Clinical studies have shown that CGRP levels are elevated during the painful phase of migraine headache, then restored to baseline by antimigraine 5-HT1 drugs. …”
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CD206+ Trem2+ macrophage accumulation in the murine knee joint after injury is associated with protection against post-traumatic osteoarthritis in MRL/MpJ mice. by Jillian L McCool, Aimy Sebastian, Nicholas R Hum, Stephen P Wilson, Oscar A Davalos, Deepa K Murugesh, Beheshta Amiri, Cesar Morfin, Blaine A Christiansen, Gabriela G Loots

“…Post-traumatic osteoarthritis (PTOA) is a painful joint disease characterized by the degradation of bone, cartilage, and other connective tissues in the joint. …”
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La propagande anti-britannique en France pendant l’Occupation by Françoise Passera

“…Propaganda was also based on the painful history of France and Great Britain so as to convince the French that England had always tried to deprive France of her colonies and that it was what she was trying to do by maintaining her presence in Africa. …”
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MicroRNA-219 in the central nervous system: a potential theranostic approach by Nahal Shamaeizadeh, Mina Mirian

“…MicroRNA-219 is a specific brain-enriched miRNA associated with neurodevelopmental disorders that play crucial roles in the differentiation of oligodendrocyte progenitorcells, promotion of oligodendrocyte maturation, remyelination, and cognitive functions to the extent that it can be considered a potential therapeutic option for demyelination in multiple sclerosis and spinal cord injury and reverse chronic inflammation pains. Additionally, miR-219 regulates the circadian clock, influencing the duration of the circadian clock period. …”
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Informational support for women with endometriosis: a scoping review by Deniz Senyel, James H. Boyd, Melissa Graham

“…Abstract Background Ten per cent of women of reproductive age suffer from endometriosis, a painful and incurable disease that leaves women with severe implications for their health and overall well-being. …”
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Ocular traumatic behavior in patients discharged from the Cuban Institute of Ophthalmology. by Dany Curbelo Concepción, Idalia Triana Casado, Juan C. Medina Perdomo

“…In order to prevent those traumas some actions could be carried out, above all, in early ages where the sight loss is quite painful.…”
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