Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy by Wen-Ying Yu, Wen-Ying Yu, Jing Liu, Jing Liu, Ze-Hao Lin, Ze-Hao Lin, Hong Liu, Hong Liu, Liang-Zhi Zhang, Liang-Zhi Zhang, Xiang-Long Feng, Xiang-Long Feng, Zhong-Biao Xiu, Zhong-Biao Xiu, Zhong-Biao Xiu

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Role of emotional disorders, personality features and disorders of intraceptive sensation in development of somatic symptoms at irritable bowel syndrome by Ye. A. Poluektova, A. A. Kurbatova, G. Ye. Rupchev, A. A. Sheptulin, V. T. Ivashkin

“…Number of days of feeling sick for the last year, number of medical encounters for the same time, intensity of abdominal pain according to VAS, frequency of bowel movements per day (number of defecations per day at IBS-D and number of defecations per week at IBS-C) were taken into account in correlation to disease severity and severity of anxiety and depression according to respective scales, to personality features of patients, and also to pattern and volume of individual dictionary for description of internal somatic sensations. …”
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Joint effect of modifiable risk factors on Parkinson’s disease: a large-scale longitudinal study by Panlong Li, Xirui Zhu, Min Liu, Yanfeng Wang, Chun Huang, Junwei Sun, Shan Tian, Yuna Li, Yuan Qiao, Junting Yang, Shanshan Cao, Chaohua Cong, Lei Zhao, Jingjing Su, Dandan Tian

“…The top 5 factors were hand grip strength (hazard ratio (HR) = 0.98, p = 1.59 × 10−24), long-standing illness (HR = 1.38, p = 3.63 × 10−20), self-reported nervousness (HR = 1.56, p = 5.9 × 10−20), ever suffered from mental health concerns (HR = 1.42, p = 5.48 × 10−18) and chest pain (HR = 1.42, p = 1.43 × 10−18). Individuals with unfavorable medical history, psychosocial factors, physical measures, and lifestyle had an increased risk of PD by 33 to 51% compared to those with favorable factors (p < 0.001).DiscussionResults indicated that addressing modifiable risk factors, especially in physical measures and psychological factors, could potentially prevent up to 33.87% of PD cases. …”
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Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil) by Cássio Braga e Braga, Antonio Camargo Martins, Athaid David Escalante Cayotopa, Wagner Werner Klein, Andreus Roberto Schlosser, Aline Ferreira da Silva, Mardelson Nery de Souza, Breno Wilson Benevides Andrade, José Alcântara Filgueira-Júnior, Wagner de Jesus Pinto, Mônica da Silva-Nunes

“…The most frequent symptoms before medication were headache, fever, chills, sweating, arthralgia, back pain, and weakness, which were present in between 40% and 76% of respondents. …”
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Correlation between social support, self-efficacy and quality of life in primary trigeminal neuralgia patients (原发性三叉神经痛患者社会支持、自我效能感与生活质量的相关性研究)... by SUN Xiuxiu (孙秀秀), JIA Jianhua (贾建华), LI Yeyuan (李业园)

“…Methods Totally 220 primary trigeminal neuralgia patients who were 18 years old or older were conveniently selected from a tertiary hospital in Jinan City, and were surveyed with self-designed general information questionnaires, social support scales, chronic pain self-efficacy scales, and trigeminal neuralgia patients' quality of life questionnaires. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…Secondary outcomes will include device-based (activPAL3TM) and self-reported (Global Physical Activity Questionnaire and Workforce Sitting Questionnaire) physical activity and sedentary behaviour; self-reported musculoskeletal disorders (Standardised Nordic Questionnaire) and pain (Numeric Rating Scale); self-reported presenteeism and absenteeism (Health and Work Performance Questionnaire), job satisfaction (Need for Recovery scale) and fatigue (single-item 5-point Likert scale). …”
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Comparing the efficacy of 3D-printing-assisted surgery with traditional surgical treatment of fracture: an umbrella review by Lin Xiao, Peiyuan Tang, Shengwu Yang, Jingyue Su, Wenbo Ma, Han Tan, Ying Zhu, Wenfeng Xiao, Ting Wen, Yusheng Li, Shuguang Liu, Zhenhan Deng

“…For proximal humerus fracture, 3D printing helps shorten operation time (weighted mean difference (WMD) = −19.49; 95% CI −26.95 to −12.03; p < 0.05; I 2 = 91%), reduce blood loss (WMD = −46.49; 95% CI -76.01 to −16.97; p < 0.05; I 2 = 98%), and get higher Neer score that includes evaluation of pain, function, range of motion, and anatomical positioning (WMD = 9.57; 95% CI 8.11 to 11.04; p < 0.05; I 2 = 64%). …”
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Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia by V. T. Ivashkin, I. V. Maev, Yu. A. Shelygin, E. K. Baranskaya, S. S. Belous, E. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. V. Veselov, E. G. Grigoryev, N. V. Kostenko, V. N. Kashnikov, V. F. Kulikovskiy, I. D. Loranskaya, O. S. Lyashenko, E. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, O. Yu. Fomenko, D. A. Khubezov, E. Yu. Chashkova, G. I. Chibisov, M. V. Shapina, A. A. Sheptulin, O. S. Shifrin, A. S. Trukhmanov, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, O. Yu. Zolnikova, N. V. Korochanskaya, S. N. Mammayev, I. B. Khlynov, V. V. Tsukanov

“…IBS is a functional bowel disorder manifested with recurrent, at least weekly, abdominal pain with the following attributes (any two leastwise): link to defecation, its frequency or stool shape. …”
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Clinical efficacy and safety of acupuncture at Houtian Baguapoint around umbilicus combined with acupoint massage in the treatment of primary dysmenorrhea (针刺脐后天八卦穴联合穴位按摩治疗原发性痛经的临床... by HE Yan (何宴), DUI Minjie (杜敏杰)

“…The Cox Menstrual Symptom Scale(CMSS) and Visual Analogue Scale (VAS) were used to compare the dysmenorrhea status and pain degree of patients in the two groups, and the adverse reactions of patients in the two groups were compared. …”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…Case studies of MFS patients have documented neurovascular manifestations, including intracranial aneurysms, stroke, arterial tortuosity, as well as headaches and migraines, with reported incidences of pain and chronic fatigue. Despite these significant clinical observations, investigation into cerebrovascular dysfunction and neuropathology in MFS remains limited.MethodsUsing 6M-control (C57BL/6) and 6M-MFS (Fbn1C1041G/+) and healthy 12M-control male and female mice, we test the hypothesis that abnormal Fbn1 protein expression is associated with altered cerebral microvascular density, BBB permeability, and neuroinflammation in the PCA-perfused hippocampus, all indicative of a pre-mature aging brain phenotype. …”
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Immunological composition of human milk before and during subclinical and clinical mastitis by Irma Castro-Navarro, Ryan M. Pace, Ryan M. Pace, Ryan M. Pace, Janet E. Williams, Christina D. W. Pace, Harpreet Kaur, Julia Piaskowski, Alberto Aragón, Alberto Aragón, Juan M. Rodríguez, Juan M. Rodríguez, Mark A. McGuire, Leonides Fernandez, Leonides Fernandez, Michelle K. McGuire

“…Mastitis, an inflammatory condition affecting more than 25% of breastfeeding women, is usually associated with reduced milk secretion, pain, and discomfort, which often leads to early cessation of breastfeeding. …”
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Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy population: a randomized, blind, parallel controlled phase III clinical study by Xiaoyan Ding, Weixin Du, Qiao Liu, Lifeng Tao, Yan Shao, Peng Lu, Huaiyu Yang, Xiaoxue Teng, Cheng Chen, Zhongqi Li, Jinbiao Lu, Aihua Zhao, Guozhi Wang, Miao Xu, Limei Zhu

“…Most of these were local adverse reactions, including injection site pain, pruritus, and rash. Conclusions The diagnostic performance of the EC skin test was similar to that of the T-SPOT test in the healthy population and was unaffected by BCG vaccination. …”
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Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis by Paul Garner, Lawrence Mbuagbaw, Jason W Busse, Dena Zeraatkar, Thomas Agoritsas, Ariel Izcovich, Tari Turner, Lyn Turkstra, Roger S McIntyre, Rachel J Couban, Tyler Pitre, Sarah Kirsh, Tanvir Jassal, Michael Ling, Samantha Chakraborty, Signe A Flottorp

“…Our outcomes of interest will include patient-reported fatigue, pain, postexertional malaise, changes in education or employment status, cognitive function, mental health, dyspnoea, quality of life, physical function, recovery and serious adverse events.For each outcome, when possible, we will perform a frequentist random-effects network meta-analysis. …”
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Effect of feedforward control combined with tracking method on reducing the incidence of blockage of intravenous indwelling needle in perioperative patients (前馈控制追踪法在降低围手术期患者静脉留置针堵... by ZHANG Jianfang (张建芳), SHI Lihua (施丽华), LIN Yiqing (林依青), FENG Qi (冯绮), CHEN Qiyu (陈麒羽), LI Liqin (李立勤)

“…Conclusion The feedforward control combined with tracking method is potentially effective to reduce the incidence of blockage of intravenous indwelling needle, prolong the indwelling time, reduce the pain at puncture site and improve the comfort level of patients during the treatment. …”
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The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual... by Soo Downe, Lisa Askie, Sarah J Lord, Hannah G Dahlen, Kenneth William Finlayson, Anna Lene Seidler, Federico Girosi, Kylie Elizabeth Hunter, Kate M Levett, Mary-Ann Davey, Caroline A Smith, Julie Fleet, Mary Steen, Elizabeth Newnham, Anette Werner, Leslie Arnott, Kerry Sutcliffe

“…Methods and analysis Population: women with singleton vertex pregnancies, no planned caesarean section (CS) or epidural.Intervention: in addition to hospital-based standard care, a comprehensive antenatal education programme that includes multiple components for birth preparation, addressing the three objectives: preparing women and their birth partner/support person for childbirth through education on physiological/hormonal birth (knowledge and understanding); building women’s confidence through psychological preparation (positive mindset) and support their ability to birth without pain relief using evidence-based tools (tools and techniques). …”
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Effect of Shangke Zhitong Ointment Kinesio Tape on Ankle Sprain by WANG Qiang, LIU Zhiyang, JU Shaohua, LI Xiaodong, HUANG Jichao, XIANG Ning

“…Compared with the combined group, IL-1β, MDA, FGF-2, TGF-β1, MMP-9 in the Shangke kinesio tape group after treatment were significantly lower, SOD was significantly higher (<italic>P</italic>&lt;0.05).ConclusionShangke Zhitong ointment kinesio tape can inhibit inflammation, oxidative stress and other reactions after ankle sprain, relieve local swelling, pain, movement limitation and other symptoms of ankle joint, and effectively improve the ankle function of patients, which is recommended for clinical application.…”
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Development of quality indicators for hand osteoarthritis care – Results from an European consensus study by Daniel H. Bordvik, Yeliz Prior, Rachael Bamford, Francis Berenbaum, Mathilda Björk, Thalita Blanck, Barbara Slatkowsky Christensen, Krysia Dziedzic, John Edwards, Nazemin Gilanliogullari, Carol Graham, Ida K. Haugen, Margreet Kloppenburg, Hellen Laheij, Marco J.P.F. Ritt, Tanja Stamm, Anne Therese Tveter, Nina Østerås, Ingvild Kjeken

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Successful Use of Negative Pressure Wound Therapy for Abdominal Wall Necrosis Caused by a Perforated Ascending Colon Using the ABThera System by Kouki Imaoka, Takuya Yano, Yasuhiro Choda, Ko Oshita, Yuma Tani, Tetsushi Kubota, Michihiro Ishida, Daisuke Satoh, Masanori Yoshimitsu, Kanyu Nakano, Masao Harano, Hiroyoshi Matsukawa, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima

“…A 66-year-old man was admitted to our hospital with complaints of severe pain in the abdomen. On admission, abdominal contrast-enhanced computed tomography (CT) showed fluid collection, an air pocket in the subcutaneous fat layer of the abdominal wall, and edematous changes in the adipose tissue in the peritoneum and abdominal wall. …”
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Comparative analysis of morphologival parameters in isolated and fused L5 spondylolysis patients on the basis of CT features by Rui Ma, Xiaoxia Huang, Luyao Li, Ye Kai, Jun Liu, Gao Leilei, Xiangning Sun, Yong Teng

“…Patients with a pars interarticularis separation distance ≥ 2 mm were classified into the isolated group (Group A, 66 patients), while those with a separation distance < 1 mm were classified into the fused group (Group B, 51 patients).Additionally, 117 patients without spondylolysis but experiencing lower back pain were included as the control group (group C). …”
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Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP by Tongzhou Liang, Jincheng Qiu, Shaoguang Li, Zhihuai Deng, Xianjian Qiu, Wenjun Hu, Pengfei Li, Taiqiu Chen, Zhancheng Liang, Hang Zhou, Bo Gao, Dongsheng Huang, Anjing Liang, Wenjie Gao

“…Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that RORα, a member of the retinoid-related orphan receptor family, is significantly elevated in nucleus pulposus tissue in IDD patients. …”
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