Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis by Motoshi Sonoda, Keishiro Kinoshita, Nobutaka Harada, Sungyeon Park, Shunichi Adachi, Yutaro Yada, Katsuhide Eguchi, Toshifumi Fujiwara, Makiko Kido-Nakahara, Noriko Kinjo, Masataka Ishimura, Shouichi Ohga

“…This reduction correlated with improved patient pain visual analog scale (p = 0.008), CNO clinical disease activity score (p = 0.029), and better bone and joint imaging, though cytokine levels remained unchanged. …”
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Gastrointestinal lesions of eosinophilic granulomatosis with polyangiitis: a prediction model and clinical patterns by Suying Liu, Yunjiao Yang, Linna Han, Chengmei He, Mengtao Li, Xinping Tian, Juan Meng, Li Wang, Fengchun Zhang

“…Common manifestations included abdominal pain (78%), diarrhea (40.4%), and nausea and/or vomiting (32.7%). …”
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Acute fibrinous and organizing pneumonia after lung transplantation: A case report of treatment with infliximab and tocilizumab and literature review by Christophe Abellan, Foteini Ioakeim, Alessio Casutt, Benoit Lechartier, Zisis Balmpouzis, Samuel Rotman, Leslie Noirez, Isabelle Rochat, John-David Aubert, Angela Koutsokera

“…She developed severe pleuritic pain needing opioid treatment and died 4 months later. …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Calls were selected based on International Classification of Primary Care codes and keywords, that is, chest pain, heart complaints, heart, myocardial infarction, heart attack, heart infarction or common abbreviations of these keywords. …”
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Diagnostic Value of Sodium, White Blood Cell, Neutrophil Levels; White Blood Cell/Sodium and Neutrophil/Sodium Ratios in Appendicitis in Pediatric Patients by Cem Kaya, Gökhan Arkan, Fatma Nur Aracıer Uçaner, Leyla Nur Türker, Alparslan Kapısız, Ramazan Karabulut, Zafer Türkyılmaz, Kaan Sönmez

“…Objective: Acute appendicitis is one of the most common causes of abdominal pain requiring surgical intervention in children. …”
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Intramedullary Fixation for Metacarpal Fractures: A Multi-Institutional Prospective Outcomes Study by Michael B. Gehring, MD, Brandon Wolfe, BA, Riley Kahan, BS, Stephanie D. Malliaris, MD, Kia M. Washington, MD, Matthew D. Folchert, MD, Kyros Ipaktchi, MD, Mark A. Greyson, MD, Alexander Lauder, MD, Matthew L. Iorio, MD

“…Radiographic healing was assessed at each postoperative visit and patient-reported outcomes included pain scores, QuickDASH (Disabilities of the Arm, Shoulder, and Hand), and Short Form Survey scores. …”
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When specific exercise is more effective than medication - Sensorimotor training is currently the most promising option to treat and prevent chemotherapy-induced peripheral neuropa... by Fiona Streckmann, Maryam Balke, Céline Hammadou, Bianca Schmidli, Oliver Faude, Sarah Koch

“…Improvements in favor of SMT compared to TAU were furthermore found for balance control bipedal with eyes open; bipedal with eyes closed; monopedal, vibration sensitivity, sense of touch, lower leg strength, pain reduction, burning sensation, chemotherapy dose reductions, and mortality. …”
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Comparison of the effects of pulse and direct injection flushing methods after intravenous injection of non-irritating drugs (脉冲式和直接推注式冲管方法用于非刺激性药物输注的效果比较)... by WANG Yali (王亚丽), WEI Yongchun (魏永春), E Haiyan (鄂海燕), DONG Yuxia (董玉霞), SUN Lei (孙磊)

“…Conclusion During intravenous injection of non-irritating drugs, the direct push-type flushing method is potentially effective to reduce the incidence of blood return and tube blockage, reduce the pain of patients, and improve the clinical nurse work efficiency and nursing quality. …”
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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

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A decade of treating traumatic sternal fractures in a single-center experience in Korea: a retrospective cohort study by Na Hyeon Lee, Seon Hee Kim, Jae Hun Kim, Ho Hyun Kim, Sang Bong Lee, Chan Ik Park, Gil Hwan Kim, Dong Yeon Ryu, Sun Hyun Kim

“…Surgical indications encompassed emergency cases involving intrathoracic injuries, unstable fractures, severe dislocations, flail chest, malunion, and persistent high-grade pain. Results Of 266 patients with traumatic sternal fractures, 260 were included; 98 underwent surgical treatment for sternal fractures, while 162 were managed conservatively. …”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…Methods and Results This is a secondary analysis of patients with stable coronary artery disease who underwent both coronary computed tomography angiography  and fractional flow reserve derived from computed tomography as part of the FORECAST (Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain) trial, investigating (1) the relationship between coronary stenosis severity on coronary computed tomography angiography and fractional flow reserve derived from computed tomography FFRCT by sex and (2) the association with revascularization, resource usage, and adverse clinical events. …”
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THE EFFECT OF NUTRITIONAL THERAPY ON QUALITY OF LIFE INDICATORS FOR PATIENTS WITH GASTRIC CANCER AT THE STAGE OF SURGICAL TREATMENT by A. D. Sergienko, V. E. Khoronenko, E. V. Gameeva, A. B. Ryabov, V. M. Khomyakov

“…Patients having received nutritional therapy noted a decrease in pain, an improvement in the processes of assimilation of food, as well as an improvement in well-being, physical condition, an increase in general tone and energy, a surge of strength and a sense of vitality. …”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…The most common solicited adverse events were mild injection site tenderness and pain, and mild headache. There were no vaccine-related serious adverse events or adverse events of special interest. …”
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تاثیر دو شیوه تمرینی راه رفتن بر عملکرد جسمانی افراد مبتلا به استئوآرتریت زانو: یک مرور نظام مند و فراتحلیل مطالعات... by الناز توافقی, محمدعلی سردار, امین عظیم خانی, صادق عباسیان

“…لذا، هدف پژوهش حاضر بررسی تاثیر دو شیوه تمرینی راه رفتن بر عملکرد جسمانی افراد مبتلا به استئوآرتریت زانو: یک مرور سیستماتیک و فراتحلیل مطالعات بود که در تحقیق حاضر توانایی راه رفتن به عنوان متغیر اصلی در سنجش عملکرد جسمانی افراد در نظر گرفته شد.روش بررسی:از بین مقالات چاپ شده از ژانویه سال 1990 لغایت جولای سال 2024 در زمینه استئوآرتریت زانو و تمرینات مختلف با کلمات کلیدی مرتبطMuscle Strength AND Osteoarthritis AND Pain AND Rehabilitation, Walking OR Walking Speed و تمامی این کلمات در ترکیب با کلمه کلیدی Physical Function، مقالات مرتبط با این موضوع از بانک‎های اطلاعاتی Medline/PubMed, Science Direct, Scopus و Web of Science مورد بررسی قرار گرفت. …”
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Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials by Na-Yeon Ha, Chang-Yul Keum, Jinsung Kim

“…The combined Tuina group demonstrated significantly lower overall dyspeptic symptom scores (standard mean difference (SMD) = -1.18, 95 % CI [-1.46, −0.91], p < 0.00001) and shorter times to resolution of primary symptoms, including abdominal distension (mean difference (MD) = -2.08, 95 % CI [-2.35, −1.81], p < 0.00001), abdominal pain (MD = −1.54, 95 % CI [-1.92, −1.17], p < 0.00001), belching (MD = −1.11, 95 % CI [-1.44, −0.77], p < 0.00001), and anorexia (MD = −1.37, 95 % CI [-1.67, −1.07], p < 0.00001). …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, whether dmNPC can be treated with immunochemotherapy alone (without LRRT) remains controversial.Case presentationWe report two cases of dmNPC, both in middle-aged men who mainly presented with epistaxis and systemic pain. Radiological examination with positron emission tomography–computed tomography (PET-CT) and contrast-enhanced magnetic resonance imaging (MRI) showed NPC with multiple systemic lymph node metastases, multiple bone metastases, and liver metastases. …”
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Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial by Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali

“…For example, Visual Analogue Scale Stress at the hospital improved at admission by 5% and at hospital discharge by 11.1% and Visual Analogue Scale Pain at admission improved by 31.2%. In addition, Hospital Anxiety and Depression Scale Anxiety after surgery improved by 15.6%, and Positive and Negative Affect Scale-Negative at hospital admission improved by 17.5%. …”
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LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis by Ma C, Chen Q, Wei YF, Chen SW, Liu H, Xin F, Ren YX

“…Cheng Ma,1,&ast; Qi Chen,2,&ast; Yi-Fan Wei,1,&ast; Shu-Wen Chen,3 Huan Liu,4 Feng Xin,5 Yong-Xin Ren1 1Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Department of Orthopaedics, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Department of Clinical College, The First Clinical School of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 4Department of Orthopaedics, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China; 5Department of Orthopaedics, Xuzhou Cancer Hospital, Xuzhou, Jiangsu, 221005, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Feng Xin; Yong-Xin Ren, Email 925866554@qq.com; renyongxinjsph@163.comBackground: Osteoarthritis (OA) is a leading cause of pain, disability, and reduced mobility worldwide, characterized by metabolic imbalances in chondrocytes, extracellular matrix (ECM), and subchondral bone. …”
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Endoscopic Submucosal Dissection of the Angiolipoma at Hypopharynx-Esophageal Introitus by Lu Liu, Feng Miao, Hai-Mei Guo, Nuo Li, Shu-Hua Jiao, Shuang Cai, Peng-Liang Liu, Shan-Shan Zhang, Jia Ma, Yang Weng, Ying Sun, Yin-Si Tang, Feng Zhao, Yan Zheng, Shen Zhang, Yan Yang, Yang Yu, Lei Tian, Zhi-Feng Zhao

“…Endoscopic thermocoagulation successfully stopped bleeding in all cases. Pharyngeal pain and painful swallowing were the main clinical signs. …”
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Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…Subacute thyroiditis (SAT) is an inflammatory thyroid disease characterized by neck pain, tenderness, general symptoms and thyroid dysfunction. …”
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