First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…Five patients experienced a severe (≥ grade 3) TRAE; neutropenia (n=2), febrile neutropenia (n=1), chest pain (n=1), increased liver enzymes (n=1), and leukopenia and thrombocytopenia (n=1). …”
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The effects of war-related experiences on mental health symptoms of individuals living in conflict zones: a longitudinal study by Doron Amsalem, Shilat Haim-Nachum, Amit Lazarov, Yossi Levi-Belz, John C. Markowitz, Maja Bergman, Alexandra Klein Rafaeli, Lisa A. Brenner, Nitsa Nacasch, Milton L. Wainberg, Ido Lurie, Shlomo Mendlovic, Yuval Neria

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Management of Irritable Bowel Syndrome: Novel Approaches to the Pharmacology of Gut Motility by Carmelo Scarpignato, Iva Pelosini

“…As a consequence, drugs affecting gastrointestinal (GI) motility have been widely employed with the aim of correcting the major IBS manifestations, ie, pain and altered bowel function. Unfortunately, no single drug has proven to be effective in treating IBS symptom complex. …”
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Non-Anatomic Reconstruction in Multiligament Knee Injuries: A Functional Approach by Mihai Hurmuz, Cătălin-Adrian Miu, Daniel Ceachir, Romulus-Fabian Tatu, Mihai Andrei, Bogdan Andor, Alexandru Catalin Motofelea, Călin Tudor Hozan

“…The results demonstrated significant improvements across all scoring systems, with enhanced knee stability, reduced pain, and better quality of life. <i>Conclusions</i>: These findings support the feasibility of non-anatomic reconstructions as a practical solution for patients seeking a return to daily activities and recreational sports without the complexity of full anatomic reconstruction.…”
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Comparison of Nasopharyngeal Airway with Endoscopic Respiratory Mask for Hypoxemia in Painless Gastrointestinal Endoscopy in Obese Outpatients: Study Protocol for a Randomized Cont... by Xiang D, Deng L, Zhou R, Zhang X, Tian L, Jiang W, Zhou Y, Chen W, Peng Y

“…The secondary outcomes will be the incidence of epistaxis, suspended examination due to hypoxemia, manual ventilation, the times of attempt to nasopharynx airway insertion, duration of insertion of nasopharyngeal airway, tracheal/laryngeal mask intubation, adverse cardiovascular events, gastrointestinal complications, VAS score of nasopharynx pain after removing the nasopharyngeal airway, satisfaction score of patients, endoscopist and anesthesiologists.Discussion: This study evaluates the effects of nasopharyngeal airway insertion on hypoxemia caused by procedural sedation in obese patients undergoing gastrointestinal endoscopy. …”
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Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? by Ajami Gikandi, BA, Zhi Ven Fong, MD, MPH, DrPH, Motaz Qadan, MD, PhD, Raja R. Narayan, MD, MPH, Thinzar Lwin, MD, MS, Carlos Fernández-del Castillo, MD, Keith D. Lillemoe, MD, Cristina R. Ferrone, MD

“…Patients experiencing complications also reported lower pancreatic pain (38.2 vs 43.4, P < 0.05, CR small) and altered bowel habits (30.1 vs 40.7, P < 0.01, CR moderate) symptom scores. …”
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Effectiveness and cost-effectiveness of a web-based routine assessment with integrated recommendations for action for depression and anxiety (RehaCAT+): protocol for a cluster rand... by Reinhold Kilian, Harald Baumeister, Yannik Terhorst, Johannes Knauer, Paula Philippi, Selina Kallinger, Sandro Eiler, Tamara Waldmann, Morten Moshagen, Martina Bader

“…Secondary outcomes are depression at discharge (T1) and 6 months follow-up (T2) as well as anxiety, satisfaction with participation in social roles and activities, pain impairment, fatigue, sleep, health-related quality of life, self-efficacy, physical functioning, alcohol, personality and health economic-specific general quality of life and socioeconomic cost and benefits at T1-3. …”
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MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3 by Bin Wang, Ping Yu, Wei Lin, Zhaohui Zhai

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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury by Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park

“…At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). …”
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Benefits of a Juvenile Arthritis Support Program (JASP-1) for children recently diagnosed with Juvenile Idiopathic Arthritis and their parents by Karina Mördrup, Johanna Granhagen Jungner, Eva Broström, Karin Palmblad, Cecilia Bartholdson

“…However, children suffer from pain and anxiety, and parents often experience loneliness and lack of support. …”
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Biomechanical Effects of Different Spacing Distributions Between the Cemented Superior Boundary and Surgical Vertebral Superior Endplates After Percutaneous Vertebroplasty for Oste... by Xiao Meng, Chengqiang Zhou, Yifeng Liao, Haibin Zhou, Hua Li, Jiayuan Liu, Xuebin Tang, Yunqing Wang

“…ABSTRACT Objective Patients with osteoporotic vertebral compression fractures (OVCF) treated with vertebroplasty (PVP) are experiencing an increasing number of problems such as pain recurrence, mainly due to recompression fractures of the operated vertebral body within a certain period of time after the operation, which is closely related to the distribution of intraoperative bone cement. …”
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A comparative study on the efficacy of kirschner wire tension band combined with anchor cross-suture internal fixation versus partial patellectomy in the treatment of comminuted in... by Siyu Duan, Rongda Xu, Hanfei Liu, Ming Sun, Hairui Liang, Zhencun Cai

“…In Group A, one patient experienced complications from hardware irritation, while in Group B, one patient had postoperative knee pain, and two patients experienced knee extension weakness after cast removal and rehabilitation. …”
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The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant by S. A. Frolov, A. M. Kuzminov, V. Yu. Korolik, I. S. Bogormistrov, M. O. Chernozhukova, Sh. T. Minbayev

“…Surgical intervention was carried out under local anesthesia, duration averaged 16 min (12 to 26), no intra­operative morbidity was registered. Pain intensity in postoperative period was minimal. …”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…Dysfunction of these channels is associated with neurological disorders such as epilepsy, neuropathic pain, and myopathies. Although plant-derived compounds have shown promise in modulating Nav channels, the molecular mechanisms remain insufficiently understood. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

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Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data by Wang Lingying, Zhu Hong, Chen Hongxiu, Hu Ziyi, Feng Mei, Tang Menglin, Hu Xiuying

“…Recognizing the role of BMI categories in this context is essential for developing targeted preventative strategies for the elderly, while also accounting for other modifiable risk factors such as pain and depression.…”
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Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States by Chan Shen, Hao Wang, Arthur Nguimatsa Djiotsop, R. Constance Wiener, Mona Pathak, Sophie Mitra, Patricia A Findley, Usha Sambamoorthi

“…Logistic regression models estimated unadjusted (Model 1) and adjusted associations accounting for sex, race/ethnicity, age, social determinants of health (Model 2), general health (Model 3), depression (Model 4), and pain and physical activity (Model 5). Results: The study cohort included 8877 participants aged ⩾50 years in 2018 (baseline) who were followed up in 2020. …”
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Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health by O.E. Dorofieieva, K.S. Yarymbash, O.A. Glinyana, Yu.V. Syomych, I.T. Skrypchenko

“…In the course of the clinical and instrumental methods of examination of patients with mine-explosive wounds at the level of the lower leg, the assessment of categories according to the ICF revealed disorders at the level of structure: functions: s 75010 bones of lower leg, s 75012 muscles of lower leg, s 75013 ligaments and fasciae of lower leg, s 8104 skin of lower extremity; b 28015 pain in the lower limb, b 4550 general physical endurance, b 7101 mobility of several joints, b 7351 muscle tone of one limb, b 770 function of the stereotype of walking, b 7800 sensation of muscular stiffness, b 810 protective function of skin; activities: d 4104 standing position, d 4106 moving the center of gravity of the body, d 4501 walking long distances, d 465 moving using technical means, d 5100 washing body parts, d 5102 wiping and drying, d 5402 putting on footwear, d 5403 taking off footwear, d 5702 self-health support, d 850 well-paid work, d 920 recreation and leisure, e 1151 assistive products and technologies for personal everyday use, e 310 close relatives, e 355 professional health care workers. …”
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Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…Patients with lower serum omentin-1 levels suffered from higher severity of somatic symptoms (abdominal pain and distention, flatulence, rumbling), lower QOL, and worse psychological status. …”
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Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry by Giuseppe Lopalco, Maria Morrone, Fabiola Atzeni, Chiara Bazzani, Francesco Paolo Bianchi, Francesco Paolo Cantatore, Roberto Caporali, Antonio Carletto, Alberto Cauli, Maria Sole Chimenti, Sergio Colella, Fabrizio Conti, Addolorata Corrado, Ennio Giulio Favalli, Alberto Floris, Marco Fornaro, Rosario Foti, Roberta Foti, Elena Fracassi, Bruno Frediani, Stefano Gentileschi, Roberto Gorla, Elisa Gremese, Emanuela Praino, Roberta Ramonda, Cinzia Rotondo, Marco Sebastiani, Angelo Semeraro, Gianfranco Ferraccioli, Giovanni Lapadula, Florenzo Iannone

“…In mixed PsA, ASDAS-CRP scores were significantly reduced at 6 months and remained stable through 24 months (all p  < 0.0001). VAS pain scores also improved already at 6 months and continued to improve at 24 months (all p  < 0.0001). …”
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