Safety and immunogenicity of a bivalent norovirus vaccine candidate in infants from 6 weeks to 5 months of age: A phase 2, randomized, double-blind trial by Xavier Sáez-Llorens, Rodrigo deAntonio, Eduardo López-Medina, Pío López, Taisei Masuda, Paul M Mendelman, Jim Sherwood, Frank Baehner, Astrid Borkowski

“…All formulations were well-tolerated causing mainly mild-to-moderate transient solicited AEs, most frequently local pain and irritability/fussiness, but no vaccine-related serious AEs. …”
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Surgical Extirpation of Glomus Tumor from Rare Localization on the Upper Extremity by Jan Hrubý, Robert Novotný, Miroslav Špaček, Petr Mitáš, Jaroslav Hlubocký, David Janák, Ctibor Povýšil, Jaroslav Lindner

“…A 22-year-old male patient presented with bluish multifocal venous malformation on the left upper arm and was admitted for venous malformation excision. Pain, discomfort, and upper arm paraesthesia had been present for almost 6 years. …”
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Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist P... by Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw

“…Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions that include induction of pain, effects on many smooth muscle types, and lowering systemic blood pressure. …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that can result in limb pain, disability, or mortality. Notably, diabetes mellitus (DM) stands out as one of the most significant risk factors for the development of PAD. …”
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Factors Affecting The Short Term Outcome Of Pyeloplasty In Congenital Primary Unilateral Pelvi- Ureteric Junction Obstruction In Infants and Toddlers: A Single Center trial by Mostafa Sheba, Walid Ghoneima, Mohamed El Ghoneimy, Amr Mostafa, Ahmed Salem

“…The main symptom was recurrent urinary tract infect in 18 (36%) of cases, followed by loin pain in 12 (24%), hematuria in 4(8%) and 16 (32%). …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Ziziphus spina-christi (Rhamnaceae family) is a medicinal plant traditionally used to treat dandruff, wounds, hair loss, diarrhea, mastitis, abdominal pain, and gastrointestinal complications. To support this, the present work aims to study the in vitro antibacterial and antioxidant activities of compound isolates from the roots of Ziziphus spina-christi along with their in silico computational analyses. …”
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Comparative Analysis of Percutaneous Nephrostomy and Double J Stenting in Upper Urinary Tract Obstruction with Acute Kidney Injury: A Tertiary Hospital Based Prospective Study by Manzoor Ahmad, Vivek Pachauri, Saif Quaiser, Wasif Md Ali, Imad Ali, Adnan Habib

“…Most patients presented with acute kidney injury (AKI) and had symptoms of loin pain and haematuria. Both PCN and DJ stenting were equally effective in managing upper tract obstruction, with no significant differences in improvement of the laboratory parameters (e.g. …”
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Classification of kinesiophobia in patients after cardiac surgery under extracorporeal circulation in China: latent profile and influencing factors analysis from a cross-sectional... by Qi Li, Rong Wang, Yanmei Gu, Tong Ren, Jing Jing Piao, Wenhui Xing, Yujing Liang

“…The result of regression equation shows postoperative time (p<0.001), age, self-efficacy, pain and social support level (p<0.05) were the factors influencing the potential profile classification of patients after cardiac surgery under extracorporeal circulation.Conclusion The study identified three distinct classifications of patients: the low kinesiophobia group, the moderate kinesiophobia—high-risk perceived symptoms group and the high kinesiophobia—high exercise avoidance group (HK-HEAG). …”
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Effect of Neck Exercises Combined with Stimulating Baihui and Yongquan Acupoints Based on the Concept of Muscle and Bone Balance on Patients with Cervical Hypertension by CHEN Xiuming, LIN Jian, LIU Jinyong, FANG Yuelong, ZHAN Zhengxuan, HE Zhen, CAI Shuhe

“…Compared with the control group, SBP, DBP, VAS score, NDI score and TCM syndrome score of the observation group after the treatment decreased more significantly (<italic>P</italic>&lt;0.05), and the total effective rate of antihypertensive of the observation group was significantly higher than that of the control group, the difference was statistically significant (<italic>P</italic>&lt;0.05).ConclusionNeck exercises combined with stimulating Baihui and Yongquan acupoints based on the concept of muscle and bone balance can effectively reduce blood pressure and neck pain of CHBP patients with Yin deficiency and Yang hyperactivity, and improve cervical function, which is worthy of clinical application.…”
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Nutrition and Physical Therapy in the Prevention and Treatment of Endometriosis by Paulina Krzemińska, Maciej Gołębski, Wojciech Nowak, Jagoda Mikołajczyk, Zuzanna Kukla, Stella Mieruszyńska, Izabela Sadowska, Joanna Kołodziej, Mirosław Sawicki, Jakub Włosiański, Sebastian Musialik

“…Sick women suffering from this condition often have non-specific symptoms, such as pelvic pain and are often associated with the menstrual cycle. can lead to reduced mental, physical, and social well-being and a lower quality of life. …”
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Alerting the illusion of smoking improves quality of life in Chinese male cancer survivors by Juan Xia, Peng Wu, Jiwei Wang, Jinming Yu

“…Results Current smokers were reported to have higher scores in social, role, cognitive functioning, and had lower scores in nausea/vomiting, pain, dyspnea, and insomnia (P < 0.05). Former smokers had higher global health status and experienced less appetite loss and constipation (P < 0.05). …”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…Group A also exhibited significantly higher rates of overall adverse events including hypertension, abdominal pain, leukopenia, thrombocytopenia, and hypoproteinemia as compared to Group B, although the incidence of hand-foot syndrome in Group A was significantly reduced as compared to Group B (13.3% vs 42.8%). …”
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Characterization of Vaginitis Among Women Complaining of Genital Tract Symptoms by Hemin Muheddin Kareem, Muhammed Saed Qadir, Safa Bakr Karim, Solaf Jawhar Ali

“…In addition, the treatment of vaginitis can be done by topical application of Lidocaine 5% ointment (as a local anesthetic) nightly for seven weeks has been shown to decrease the pain of vaginitis in women.   …”
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Epidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years by Ting Li, Xiangpan Kong, Dawei He

“…Childhood malignant solid tumors were primarily diagnosed due to the discovery of mass/occupancy (34.9%), abdominal pain/bloating (21.1%), or fever (6.3%). 74.4% of neuroblastomas and 54.7% of nephroblastomas were diagnosed at an advanced stage. 84.4% of patients underwent surgery, and 71.9% received chemotherapy, with chemotherapy rates showing an upward trend. …”
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Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia by Yoshizo Matsuka, Teruhiko Yokoyama, Yumiko Yamamoto, Tomonori Suzuki, Ni Nengah Dwi Fatmawati, Atsushi Nishikawa, Tohru Ohyama, Toshihiro Watanabe, Takuo Kuboki, Atsushi Nagai, Keiji Oguma

“…Intradermal injection of NTX in the area of IoNC alleviated IoNC-induced pain behavior and reduced the exaggerated FM4-64 release in trigeminal ganglion neurons.…”
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Optimization and Evaluation of <i>Cannabis</i>-Based Magistral Formulations: A Path to Personalized Therapy by Bożena Grimling, Magdalena Fast, Magdalena Okoniewska, Artur Owczarek, Bożena Karolewicz

“…The formulation could be used for rectal or vaginal administration, thereby providing dosage control in the treatment of endometriosis and other conditions involving pain. In this study, two substrates from suppositories with standardized <i>Cannabis extractum normatum</i> (CEX) were used: cocoa butter and Witepsol^® H15. …”
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Nursing management in the surgical treatment of transposition of the left common carotid artery to the left subclavian artery after endovascular aortic repair for Stanford type B a... by JIANG Ningli (蒋宁莉), LI Xiu (李秀)

“…Key Points of nursing included preoperative evaluation of non-complex and complex Stanford type B aortic dissection, pain control and target blood pressure management and prevention of rupture and reverse tearing; enhancing the blood pressure monitoring; observation of surgical incisions and prevention of respiratory arrest; enhancing the postoperative anticoagulation to prevent the thrombosis or coagulation disorders; observation on vital signs and chief complaint and prevention of postoperative complication. …”
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The Association of Depression and Anxiety Disorders With Gastrointestinal Symptoms Among Nurses by Behnam Masihipour, Fariborz Mansour-Ghanaei, Saman Maroufizadeh, Soheil Hassanipour, Mehrnaz Asgharnezhad, Adele Isanazar, Kourosh Mojtahedi, Farahnaz Joukar

“…The most frequent GI symptom was abdominal pain (5.9%). Depression and anxiety were significantly associated with GI symptoms (P<0.05). …”
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Analysis of pulmonary sequestration cases, based on the 11-year birth defects surveillance data of Changsha hospitals by Ruobin Xie, Tao-Sha Wang, Yanling Wang, Wei-Dong Wang

“…The manifestations are repeated lung infections, dry cough, chest pain, chest tightness, and hemoptysis. Some cases have no symptoms in childhood and are misdiagnosed and mistreated because of lung imaging findings in adulthood. …”
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Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

“…A 40-year-old lady presented with a three-month history of right upper abdominal pain with nausea, vomiting, and significant loss of weight associated with scleral icterus and progressive abdominal distension. …”
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