Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation, joint pain, and progressive cartilage and bone erosion. …”
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Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors by Yuting Qian, Tingting Bai, Juanjuan Li, Yi Zang, Tong Li, Mingping Xie, Qi Wang, Lifu Wang, Ruizhe Shen

“…The main indications for MGCE in minors were Crohn’s disease, gastrointestinal bleeding, and abdominal pain. The main causes of gastric disease were gastric inflammatory hyperplasia, exudative gastritis, and polyps. …”
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Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies by Aishwarja Dey, Subarna Rani, Rabindra Nath Acharyya, Apurba Kumar Barman, Khondoker Shahin Ahmed, Nripendra Nath Biswas, Shrabanti Dev, Asish Kumar Das

“…This plant has been traditionally used to treat hepatitis, liver disorders, ulcers, diarrhea, gastrointestinal disorders, hemorrhage, pain, inflammation etc. Here we investigated the safety and anti-allergic potential of C. decandra leaves. …”
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First-line combination therapy of immunotherapy plus anti-angiogenic drug for thoracic SMARCA4-deficient undifferentiated tumors in AIDS: a case report and review of the literature by Xiaoling Wei, Xiangju Xing, Wei Yao, Changzheng Wang, Yajie Xiao, Xianzhi Du

“…These tumors are generally resistant to conventional cytotoxic chemotherapy, thereby limiting the availability of effective treatment options.Case presentationWe describe a 69-year-old AIDS patient who initially presented with a fused, enlarged lymph node on the right clavicle and mild, unexplained pain under the right axilla that worsened with severe coughing episodes. …”
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Medial and Lateral Meniscus Posterior Root Tears with an Intact Anterior Cruciate Ligament by Yuki Okazaki, Takayuki Furumatsu, Yuya Kodama, Yoshinori Matsumoto, Motoki Takahashi, Toshifumi Ozaki

“…A 67-year-old woman complained of right knee pain during weeding in a deep knee flexion position. …”
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Transient Third-Degree Atrioventricular Block in a Dog with Addisonian Crisis by Paula Maria Pașca, Gheorghe Solcan, Andrei Blageanu, Caroline Maria Lăcătuș, Petru Cosmin Peștean, Constantin Adrian Stancu, Andrei Radu Baisan

“…On admission, the patient had bradycardia, low blood pressure, and mild abdominal pain. Serum biochemistry information revealed severe hyperkalemia, hyponatremia, hypoglycemia, and mildly increased liver and kidney parameters. …”
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The Impact of Blood Flow Restriction Training on Tibial Bone Stress Injury Rehabilitation: An Exploratory Case Series by Andrew P Golden, Kathleen K Hogan, Jamie B Morris, Bryan B Pickens

“…Participants showed significant mean changes in LEFS (15.15 points), PROMIS physical function (8.98 points), PROMIS social participation (7.60 points), PROMIS anxiety (3.26 points), and PROMIS pain interference (8.39 points) at four weeks. # Conclusion The utilization of BFR in the early rehabilitative management of tibial BSI may help mitigate decrements in both bone and muscle tissue during periods of decreased physical loading…”
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Oral Health Differences Between Middle-Aged and Older Adults in South Korea by Yoonjung Ji, Wonhee Baek

“…However, cognitive function, dental visits, body mass index, severe pain, functional limitations, and cognitive function exhibited distinct patterns between the age groups. …”
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The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy by Weifeng Shan, Shuying Gao, Mengting Ai, Haiyan Lan, Gongchen Duan, Xiaoli Dong, Qiaomin Xu, Yini Wu, Jimin Wu

“…The incidence rates of body movement, respiratory depression, and adverse effects were compared among the groups.ResultsThe incidence of injection pain was much higher in Group P (64.1%) than that in Group R (3.4%) and Group C (3.2%, both P < 0.001). …”
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Preliminary Study by Differential Scanning Calorimetric Analysis of Red Blood Cells in Peripheral Artery Disease Patients Treated with Cilostazol: Correlation with Improvements in... by Dénes Lőrinczy, Dorottya Szabó, László Benkő

“…<b>Objective</b>: Peripheral artery disease (PAD) is a prevalent vascular condition characterized by arterial narrowing, which impairs blood flow and manifests as intermittent claudication, a pain or cramping sensation induced by physical activity or ambulation. …”
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Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study by S. E. Silva Filho, S. Dainez, M. A. M. C. Gonzalez, F. Angelis, J. E. Vieira, C. S. Sandes

“…Magnesium sulfate reduces pain scores and analgesic consumption. Its use as an analgesic resource in opioid-free or opioid-sparing techniques have also been tested. …”
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Reliability of Ultrasound Based Compressibility of the Lower Leg Anterior Tibial Muscle Compartment in Healthy Volunteers by Kay van Heeswijk, Daniëlle Spek, Jesse Muijsenberg, Loes Janssen, Michiel Winkes, Adwin R. Hoogeveen, Marc Scheltinga

“…# Background Some individuals have exercise-induced lower leg pain (ELP) caused by a chronic exertional compartment syndrome (CECS). …”
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Interventricular septal dissection secondary to acute inferior myocardial infarction: case series and literature review by Ping Chen, Xiuqin Wang, Yun Mou

“…Case presentation Case 1: A 58-year-old male with a history of hypertension and smoking presented to a local hospital due to chest tightness and pain for 4 days. Coronary angiography revealed diffuse lesions from the proximal to the middle segment of the left circumflex branch, with 80% stenosis at its most severe point, and complete occlusion of the proximal segment of the right coronary artery. …”
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Challenges in the Management of Giant Carcinoma Ex-Pleiomorphic Adenoma of the Parotid Gland in a Single Tertiary Center by Miruna Bratiloveanu, Mihai Dumitru, Andreea Nicoleta Marinescu, Crenguta Serboiu, Oana Maria Patrascu, Adrian Costache, Daniela Vrinceanu

“…The reasons for presenting to our department included a sudden increase in size in eleven cases (78.57%), pain in nine cases (64.29%), peripheral facial paralysis in eight cases (57.14%), skin invasion/ulceration in five cases (35.71%), and massive tumor hemorrhage in one case (7.14%). …”
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Biochemistry of the Thrombin-Like TLBpic and Its Purification from Bothrops pictus “Jergon de la Costa” (Reptilia: Viperidae) by Victor Ludgardo Álvarez Tohalino, Hugo Guillermo Jiménez Pacheco, Juan Raúl Jesús Zumaran Farfán, Pavel Kewin Delgado Sarmiento, Paulino Rodolfo Zegarra Panca

“…Studies related to the total venom of snake present in several organic substances act as pain mediators and are called biogenic amines, such as bradykinin, histamine, 4-hydroxytryptamine, N-methyl-5-hydroxytryptamine, N′-N′-dimethyl-5-hydroxytryptamine, and serotonin. …”
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Exploring the role of ubiquitination modifications in migraine headaches by Qian Zhu, Qian Zhu, Jin Yang, Jin Yang, Lei Shi, Lei Shi, Jieying Zhang, Jieying Zhang, Peng Zhang, Peng Zhang, Junlong Li, Junlong Li, Xiaoli Song, Xiaoli Song

“…The aim of this review is to systematically explore the role of ubiquitination in the regulation of MAPK and NF-κB signaling pathways, with a focus on the mechanisms of ubiquitinating enzymes in neuroinflammation and pain signal amplification, and to explore their potential as diagnostics, biomarkers, predictors of response to therapy, and monitoring of chronicity in migraine disease.…”
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Surgical Treatment Options for the Young and Active Middle-Aged Patient with Glenohumeral Arthritis by Sanjeev Bhatia, Andrew Hsu, Emery C. Lin, Peter Chalmers, Michael Ellman, Brian J. Cole, Nikhil N. Verma

“…Surgeons must differentiate between incidental chondral lesions from symptomatic pathology that is responsible for the patient's pain. A thorough history, physical examination, and imaging work up is necessary and often results in a diagnosis of exclusion that is verified on arthroscopy. …”
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Migrated intra-uterine device to infra-umbilical skin: a rare case report by Nigat Amsalu Addis, Yared Alem Sibhat, Yohannis Derbew Molla, Wasihun Nigdu Mengestu, Abebe Sinknew Seid, Michael Argaw Damite, Misganaw Abere Worku

“…Complications of IUD include menstrual disturbance, pelvic pain, and increased risk of ectopic pregnancy with contraceptive failure, device expulsion, uterine perforation or transmural migration with misplacement of the device. …”
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Central Serous Chorioretinopathy Associated with Corticosteroid Use in a Patient with Leber Hereditary Optic Neuropathy: A Case Report by Lepsa Zoric, Aleksandra Petrovic, Vladimir Milutinovic

“…The decline in vision developed gradually over 20 days, prior to the patient’s referral to the UKCS Eye Disease Clinic for further examination and treatment, and was not accompanied by pain during eye movements. Initial investigations upon admission to the clinic established the diagnosis of optic neuritis. …”
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Diagnosis and Treatment of Elderly and Senile Chronic Constipation: an Expert Consensus by V. T. Ivashkin, M. G. Mnatsakanyan, V. S. Ostapenko, А. P. Pogromov, V. M. Nekoval, E. A. Poluectova, Yu. V. Kotovskaya, N. K. Runikhina, N. V. Sharashkina, P. V. Tsarkov, N. O. Tkacheva, Yu. N. Belenkov

“…Chronic constipation is associated with a higher risk of cardiovascular disease and complications, impaired general perception of health and pain, growing alarm and depression, and reduced quality of life. …”
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