Patient perspectives on acromegaly disease burden: insights from a community meeting by Shruti N. Shah, Kevin C. J. Yuen, Vivien Bonert, Wenyu Huang, Jill Sisco, Chrystal Palaty, Kristen Dancel-Manning, Nidhi Agrawal

“…The findings of this report are reviewed and summarized in this study.ResultsFatigue/muscle weakness (92%) and joint pain/arthritis (90%) are the two most common and troublesome symptoms reported by meeting participants. …”
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Numerical Studies of Particle-Gas Two-Phase Flowing through Microshock Tubes by Guang Zhang, Wei Wei Wang, Xiang Hui Su, Xiao Jun Li, Wen Hao Shen, Zhe Lin

“…A needle-free drug delivery device including a microshock tube and an expanded nozzle is used for delivering solid drug powders through the skin surface without any injectors or pain. Therefore, to improve the performance of needle-free drug delivery devices, it is significantly important to investigate shock waves and particle-gas flows induced by microshock tubes. …”
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Quality, topics, and demographic trends of animal systematic reviews - an umbrella review by Bernard Friedrich Hild, David Brüschweiler, Sophia Theodora Katharina Hild, Julia Bugajska, Viktor von Wyl, Marianna Rosso, Kimberley Elaine Wever, Eva Furrer, Benjamin Victor Ineichen

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Assessment of Clavicular Shortening in Displaced Midshaft Clavicular Fractures Treated by Nonoperative Method, Plating, and Elastic Nailing: Comparative Functional Analysis—A Case... by Makesh Ram Sriraghavan, Poornima Kumararaja, Balakannan Jeyabalan

“…Patients with clavicular length shortening of >2 cm had distinct differences in their clinical outcomes compared to patients with less severe shortening (<1 cm), as it's associated with discomfort or pain, which can negatively impact a patient's quality of life and functional ability. …”
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Nonoperative management of colon and mesocolon injuries caused by blunt trauma: three case reports by Naa Lee, Euisung Jeong, Hyunseok Jang, Yunchul Park, Younggoun Jo, Jungchul Kim

“…In two cases, conservative treatment was performed without worsening abdominal pain or laboratory tests. Follow-up CT showed improvement without additional treatment. …”
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How Abdominal Irrigation During Cesarean Delivery Affects Gastrointestinal Functions and Short-term Maternal Morbidities: A Randomized Controlled Study by Canan SATIR OZEL, Zelal Rojda GUNGORDU, Nisan Helin DONMEZ, Ergul DEMIRCIVI, Oguz Devrim YARDIMCI, Abdulkadir Turgut

“…The patients were questioned regarding nausea, vomiting, highest pain scores, time of flatus, and stool passage during the postoperative period. …”
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Carbidopa/levodopa dose elevation and safety concerns in Parkinson's patients: a cross-sectional and cohort design by Michael S Okun, Peter Schmidt, David W Brodell, Nicole T Stanford, Charles E Jacobson

“…Comparisons were made on standardised scales.Results There was no significant difference in motor, mood and quality-of-life scores in patients consuming below and above the 800 mg carbidopa/levodopa threshold, though a mild worsening in dyskinesia duration was noted without worsening in dyskinesia pain and disability. In PD patients who crossed the 800 mg threshold between two consecutive clinic visits, a significant improvement in depressive symptoms and quality-of-life measures was demonstrated, and in these patients there was no worsening of motor fluctuations or dyskinesia.Conclusions The data suggest that PD patients have the potential for enhanced clinical benefits when eclipsing the 800 mg carbidopa/levodopa threshold. …”
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Ultrasound-Guided Analgesia in Cardiac and Breast Surgeries: A Cadaveric Comparison of SPIP Block with Single and Double Injections vs. DPIP Block by Carmelo Pirri, Debora Emanuela Torre, Astrid Ursula Behr, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Carla Stecco

“…The evolution of regional anesthesia techniques has markedly influenced the management of postoperative pain, particularly in thoracic surgery. As part of a multimodal analgesic approach, fascial plane blocks have gained prominence due to their efficacy in providing targeted analgesia with minimal systemic side effects. …”
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The Effects of Adverse Events and Associated Costs on Value-Based Care for Metastatic Pancreatic Ductal Adenocarcinoma by Prachi Bhatt, Jared Hirsch, Paul Cockrum, George Kim, Gabriela Dieguez

“…Rates of most nonhematologic AEs were higher in patients receiving FFX with all 4 components, with diarrhea occurring in 28.3%, abdominal pain in 31.5%, and nausea/vomiting in 41.5% of patients. …”
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Spontaneous Pneumothorax as an Atypical Presentation of Pulmonary Paracoccidioidomycosis: A Case Report with Emphasis on the Imaging Findings by Mariana Leite Pereira, Edson Marchiori, Gláucia Zanetti, Guilherme Abdalla, Nina Ventura, Carolina Pesce Lamas Constantino, Viviane Brandão, Pedro Martins, Rodrigo Canellas, Antonio Muccillo, Romulo Varella de Oliveira

“…The patient presented to the hospital with sudden and intense chest pain accompanied by dyspnea and had a six-month history of dry cough, weight loss, and progressive dyspnea on exertion. …”
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Early Sialadenitis After Radioactive Iodine Therapy for Differentiated Thyroid Cancer: Prevalence and Predictors by Ruba Riachy, Nisrine Ghazal, Mohamad B. Haidar, Ahmad Elamine, Mona P. Nasrallah

“…Sialadenitis was deemed present if there were any records of neck swelling/pain, dry mouth, or difficulty swallowing within 48 hours of RAI administration. …”
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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Endometriosis is a chronic, estrogen-dependent disorder associated with the presence of endometrial cells mainly in the pelvic cavity, causing systemic immune inflammation, infertility, epigenetic dysregulation of differential DNA methylation, coelomic metaplasia, and pain. It affects approximately 10–12% of women. Despite decades of research, full pathophysiology, a diagnostic roadmap, and clinical management strategies for endometriosis are not yet fully elucidated. …”
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Radical Pancreaticoduodenectomy for Benign Disease by D. O. Kavanagh, C. O'Riain, P. F. Ridgway, P. Neary, T. C. Crotty, J. G. Geoghegan, O. Traynor

“…The major presenting features included jaundice (five), pain (two), gastric outlet obstruction (one), and recurrent gastrointestinal haemorrhage (one). …”
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Nursing management of catheter-related bloodstream infection in a patient with peripherally inserted central catheter placement (1例PICC置管患者导管相关性血流感染的护理)... by LIU Yuchao (刘云超), SU Guohua (苏国华), E Haiyan (鄂海燕), HAN Jianping (韩建萍), WANG Yutao (王玉涛), WAN Nannan (王楠楠)

“…Based on the routine treatment and nursing, the chlorhexidine gluconate dressing and external application of Ruyi Jinhuang powder were used to relieve the upper limb swelling and pain. The combination use of chlorhexidine gluconate dressing and Ruyi Jinhuang powder external application is effective to relieve the symptoms of catheter-related bloodstream infection and improve the rehabilitation of patients. …”
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Pulmonary Embolism in the Elderly: From Symptoms to Speckle Tracking Echocardiography by Christos Ballas, Dimitrios Sfairopoulos, Ioanna Samara, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Katerina K. Naka, Lampros K. Michalis, Christos S. Katsouras

“…Compared to younger patients, elderly patients with PE had less frequently pain and typical symptoms and more often were hospitalized due to another reason before the PE diagnosis. …”
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Do We Need A Bone Block Procedure in Recurrent Anterior Shoulder Instability?: A Case Report by Hastomo Agung Wibowo, Dadang Rona Sasetyo, Yusa muhammad Thoriq, Felix Giovanni Hartono

“…The surgery was successfully performed, and there was no sign of recurrent instability and pain after one year. Discussion: The number of recurrent shoulder dislocations is over 75%. …”
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Refining MR-guided thermal ablation for HCC within the Milan criteria: a decade of clinical outcomes and predictive modeling at a single institution by Fu-Qun Wei, Pei-Shu Huang, Bing Zhang, Rui Guo, Yan Yuan, Jin Chen, Zheng-Yu Lin

“…AEs occurred in 33.7% of patients, with pain being the most common. Conclusion MR-guided ablation is effective for HCC patients within the Milan criteria, especially for those with smaller tumors and better liver function. …”
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Antioxidant and Antibacterial Activities Evaluation, Phytochemical Characterisation of Rhizome from Angiopteris helferiana and Barks from Saurauia fasciculata in Nepal by Ram Kishor Yadav, Akriti Dhakal, Kalpana Timilsina, Priyanka Shrestha, Sandesh Poudel, Sindhu KC, Prabhat Kumar Jha, Rekha Bhandari, Khem Raj Joshi

“…Among them, the red colored rhizome of Angiopteris helferiana and the bark of Saurauia fasciculata have been used widely to treat muscle fatigue, bone pain, fever, postpartum hemorrhage, and thirst by healers in Kaski and Tanahun districts, Nepal. …”
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Esophageal perforation more than 10 years after anterior cervical spine surgery: a case report and literature review by Hua Luo, Zhangfu Wang, Shuang Mi, Wenjun Pan, Xingbing Feng, Zhenghua Hong

“…Three months postoperatively, she experienced persistent right neck and shoulder pain. Despite multiple consultations, an esophageal perforation was only diagnosed 10 years later when a neck mass ruptured, discharging food debris. …”
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10 Fr S-Type Plastic Pancreatic Stents in Chronic Pancreatitis Are Effective for the Treatment of Pancreatic Duct Strictures and Pancreatic Stones by Ken Ito, Naoki Okano, Seiichi Hara, Kensuke Takuma, Kensuke Yoshimoto, Susumu Iwasaki, Yui Kishimoto, Yoshinori Igarashi

“…The median duration of pancreatic stenting was 276 days. Pain relief was obtained in 37 of 41 patients (90.2%). …”
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