COVID-19 Pandemic and IBS. Results of the All-Russian Observational Non-interventional Program to Study the Effectiveness of the Drug Kolofort® in Real Clinical Practice in Patient... by V. T. Ivashkin, R. A. Abdulkhakov, I. G. Bakulin, S. V. Zaitsev, V. I. Luchina, S. N. Mekhtiyev, S. G. Peshekhonov, E. A. Poluektova, T. I. Semenova, S. N. Serikova, G. N. Tarasova, E. A. Trush, Y. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, N. P. Chernus

Get full text

Knowledge, Practices, and Attitudes Towards Silver Diamine Fluoride Therapy Among Dentists and Students in Southeastern Spain by Clara Serna-Muñoz, Marina Lucas-Porras, Yolanda Martínez-Beneyto, Amparo Pérez-Silva, Francisco Javier Ibañez-López, Antonio José Ortiz-Ruiz

“…Similarly, for hypersensitivity treatment, 71.1% of the students were informed versus 40.7% of the general dentists, and indications for paediatric patients, 100% for the DS group and 59.3% in GDPs. …”
Get full text

Medical care and initial health status of French children returnees from jihadist group operation areas: A cross-sectional study from 2017 to 2020 in one referral French hospital by J. Goutines, L.L. Pham, N. Lucidarme, C. Briand, A. Malka, C. Baker, M. Veyret-Morau, A. Mapelli, A. Klein, T. Baubet, L. De Pontual

“…Demographic characteristics and clinical assessment of all the children included in this procedure in one paediatric center between 2017 and 2020 were retrospectively collected. …”
Get full text

Protocol for the development of a global core outcome set for the surgical treatment of differentiated thyroid cancer: a literature review and international Delphi survey by Anton F Engelsman, Romana T Netea-Maier, Christiaan F Mooij, Robin P Peeters, Menno R Vriens, A S Paul van Trotsenburg, Schelto Kruijff, Joep P M Derikx, Faridi S Jamaludin, Daniël J van de Berg, Hanneke M van Santen, Sarah C Clement, Eveline Bruinstroop, Frederik A Verburg, Angelique Seur, Els J M Nieveen van Dijkum

Get full text

Readiness of adults with type 1 diabetes and diabetes caregivers for diabetes distress monitoring using a voice-based digital health solution: insights from the PsyVoice mixed meth... by Carine de Beaufort, Guy Fagherazzi, Aurélie Fischer, Till Seuring, Franchesca Aguirre Vergara, Gloria A Aguayo, India Pinker, Maria A Tichomirowa, Siri-Maria Kamp

Get full text

Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China by Linan Zeng, Lingli Zhang, Dan Yu, Huiqing Wang, Liang Huang, Siyu Li, Guo Cheng, Zhi-Jun Jia

“…The department with the highest prevalence of PIP was the surgical department (OR 9.413; 95% CI 5.521 to 16.046), followed by the paediatric intensive care unit (PICU; OR 8.206; 95% CI 6.643 to 10.137). …”
Get full text

OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

“…Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in a dysregulated developmental hierarchy, the apex of which is defined by characteristically quiescent SOX2+ stem-like cells. …”
Get full text

Sustainability of healthcare system improvements, programmes and interventions in acute care settings: protocol for a mixed methods systematic review by Franz E Babl, Sandy Middleton, Julie Cowie, Catherine Wilson, Peter Wilson, Pauline Campbell, Emma Tavender, Lisa Kuhn, Nicola Straiton, Victoria Ramsden, Elizabeth McInnes

“…The aim of this review is to identify facilitators and barriers that influence the delivery of sustained healthcare interventions (eg, integration of clinical guidelines) within adult and paediatric hospital-based acute care settings.Methods and analysis A mixed methods systematic review updating Cowie et al’s (which included studies from 2008 to 2017) previously published systematic review will be conducted. …”
Get full text

Investigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot... by Koa Whittingham, Roslyn N Boyd, Rose Gilmore, Leanne Sakzewski, Nicola Hilton, Afroz Keramat, Bianca Thompson, Jacqui Barfoot, Christine T Moody

Get full text

Validation of the Polish version of the Functional Oral Intake Scale against flexible endoscopic evaluation of swallowing and the International Dysphagia Diet Standardization Initi... by Magdalena Milewska, Barbara Jamroz, Mariusz Panczyk, Joanna Chmielewska-Walczak, Tomasz Czernicki, Marta Dabrowska-Bender, Marcin Folwarski, Marcin Folwarski, Dorota Szostak-Wegierek

Get full text

The importance of specific exercise therapy in pediatric oncology by Bianca Celine Schmidli, Céline Hammadou, Christina Schindera, Nicolas von der Weid, Uta Tacke, Oliver Faude, Sarah Koch, Fiona Streckmann

“…In addition to the PrepAir study, the development of specific training manuals and materials will facilitate the long-term and sustainable integration of exercise therapy into the field of paediatric oncology. With this crowdfunding project (www.prepAIR.ch), we strive to equip children's hospitals with specially trained specialists and age-appropriate training material. …”
Get full text

Genetic insights into MIS-C Post-COVID-19 in Kuwaiti children: investigating monogenic factors by Mohammed Dashti, Hessa AlKandari, Hessa AlKandari, Md Zubbair Malik, Rasheeba Nizam, Sumi Elsa John, Sindhu Jacob, Arshad Channanath, Fouzeyah Othman, Safa Al-Sayed, Osama Al-Hindi, Mona Al-Mutari, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

“…Recent studies suggest that genetic predispositions, particularly monogenic forms, could significantly influence the immune responses to SARS-CoV-2 in MIS-C.MethodsWe analysed 24 children under 12 years old, all of whom met the criteria provided by the World Health Organization, 2020 for MIS-C diagnosis, from the Paediatric COVID-19 Registry in Kuwait (PCR-Q8). Demographic and clinical data were collected from medical records, and exome sequencing was performed on the children and their parents to identify rare exonic variants. …”
Get full text

Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egy... by Giuseppe Indolfi, Diana M Gibb, Aya Mostafa, Sarah Pett, Yazdan Yazdanpanah, Sylvie Deuffic-Burban, Anthony E Ades, Karen Scott, Ali Judd, Nadia Hachicha-Maalej, Clotilde Lepers, Intira Jeannie Collins, Manal H El Sayed

Get full text

Early Markers of Liver Fibrosis in Children with Beta-thalassaemia Major: A Cross-sectional Study by Himani Aggarwal, Monica Verma, Shuchi Bhalla, Dinkar Yadav, Kapil Bhalla, Abhishek Soni

“…Materials and Methods: This descriptive, cross-sectional study was conducted in the Department of Paediatrics, along with the Department of Hepatology and Gastroenterology, at Pt. …”
Get full text

Genetic counselling in the era of next generation sequencing by Diego Espada-Musitu, África Manero-Azua, Yerai Vado, Guiomar Perez de Nanclares

“…Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. …”
Get full text

Development of indicators and analysis of barriers for assessment and prevention of cutaneous graft-versus-host disease after haematopoietic stem cell transplantation in children by YANG Liling, ZHAN Sha, XUE Xiaoyan, CHEN Kai, LIU Qing, WANG Li, WANG Yiyi, WU Meng, LU Qunfeng

“…Considering the results of the analysis of the implementation rate of the indicators under review and the obstacles, alternative measures were formulated.Conclusion·There is a large gap between the evidence and clinical practice for the assessment and prevention of cutaneous GVHD after paediatric haematopoietic stem cell transplantation. …”
Get full text

Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

Get full text

Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management by Jana Táborská, Adéla Bubeníková, Petr Skalický, Jakub Táborský, David Horváth, Michal Zápotocký, Ondřej Bradáč, Vladimír Beneš, 3rd

Get full text

Perioperative outcomes in an age-adapted analysis of the German StuDoQ|Pancreas registry for PDAC by Tengis Tschaidse, Felix O. Hofmann, Bernhard Renz, Maximilian Hungbauer, Carsten Klinger, Heinz J. Buhr, Waldemar Uhl, Sören Torge Mees, Tobias Keck, Christoph Reissfelder, Michael Ghadimi, Jan G. D’Haese, Jens Werner, Matthias Ilmer

Get full text

Toward Enteral Nutrition in the Treatment of Pediatric Crohn Disease in Canada: A Workshop to Identify Barriers and Enablers by Johan Van Limbergen, Jennifer Haskett, Anne M Griffiths, Jeff Critch, Hien Huynh, Najma Ahmed, Jennifer C deBruyn, Robert Issenman, Wael El-Matary, Thomas D Walters, Cheryl Kluthe, Marie-Eve Roy, Elizabeth Sheppard, Wallace V Crandall, Stan Cohen, Frank M Ruemmele, Arie Levine, Anthony R Otley

“…In pediatric CD, EEN is now recommended by the pediatric committee of the European Crohn’s and Colitis Organisation and the European Society for Paediatric Gastroenterology Hepatology and Nutrition as a first-choice agent to induce remission, with remission rates in pediatric studies consistently >75%. …”
Get full text