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    AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, phase IV clinical study by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

    Published 2022-06-01
    “…Currently, 30 participants have been enrolled, including 20 emicizumab-naïve participants and 10 who transferred from HOHOEMI, a previous study in paediatric PwHA.Ethics and dissemination The AOZORA study was approved by the Institutional Review Boards of Nara Medical University and the St Marianna University Group. …”
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    Comparison of carbon dioxide control during pressure controlled versus pressure-regulated volume controlled ventilation in children (CoCO2): protocol for a pilot digital randomised controlled trial in a quaternary paediatric intensive care unit by Luregn J Schlapbach, Barbara Brotschi, Kristen S Gibbons, Florian Zapf, Rebeca Mozun, Daphné Chopard, Philipp Baumann, Anika Adam, Vera Jaeggi, Beat Bangerter, Juerg Burren

    Published 2025-01-01
    “…Introduction Digital trials are a promising strategy to increase the evidence base for common interventions and may convey considerable efficiency benefits in trial conduct. Although paediatric intensive care units (PICUs) are rich in routine electronic data, highly pragmatic digital trials in this field remain scarce. …”
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