Mitotic Kinases and p53 Signaling by Geun-Hyoung Ha, Eun-Kyoung Yim Breuer

“…In response to mitotic spindle damage, multiple mitotic kinases phosphorylate p53 to either activate or deactivate p53-mediated signaling. p53 can also regulate the expression and function of mitotic kinases, suggesting the existence of a network of mutual regulation, which can be positive or negative, between mitotic kinases and p53 signaling. …”
Get full text

Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables by Katrin Friedrich, Volker Dimmer, Gunter Haroske, Wolfdietrich Meyer, Franz Theissig, Berit Thieme, Klaus Dietmar Kunze

“…The p53 immunohistochemistry was performed on paraffin sections from 88 tumour samples. …”
Get full text

A Novel P53-Related Activity in a Colon Adenocarcinoma Cell Line With Mutant P53 by Andrei L. Gartel, Eugene Goufman, Charlotte Hurth, Angela L. Tyner

Get full text

Association of p53 with Neurodegeneration in Parkinson’s Disease by Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei Li

“…p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. …”
Get full text

DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells by James E. Cleaver, Eileen Crowley, Mohammed Kashani-Sabet, Charles L. Limoli

Get full text

Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools by Diana Spiegelberg, Le-Ann Hwang, Khian Hong Pua, Sashwini Chandra Kumar, Xin Yu Koh, Xiao Hui Koh, Ram Kumar Selvaraju, Kanaga Sabapathy, Marika Nestor, David Lane

Subjects: Get full text

p53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas by Paola Campomenosi, Paola Assereto, Massimo Bogliolo, Gilberto Fronza, Angelo Abbondandolo, Antonella Capasso, Patrizia F. Bellomo, Roberto Monaco, Anna Rapallo, Andrea Sciutto, Roberto Orecchia, Elio Geido, Walter Giaretti

“…The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells. …”
Get full text

Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

Subjects: Get full text

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway by Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa

Subjects: “…p53…”
Get full text

Monitoring changes in the P53 gene mutation to diagnose oral cancer by Thangavel Lakshmipriya, Subash C.B. Gopinath

“…When p53 DNA is damaged by chemical or physical factors, an increase in p53 gene transcription is noted, and the p53 protein becomes concentrated, which arrests the cell cycle at the G1/S phase, leading to cancerous characteristics in the cell. …”
Get full text

Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells by Zorka Milićević, Vladan Bajić, Lada Živković, Jelena Kasapović, Uroš Andjelković, Biljana Spremo-Potparević

“…In breast carcinoma, disruption of the p53 pathway is one of the most common genetic alterations. …”
Get full text

Investigation into the Effect of Aspartame on the Expression of p53 and BAX in Mouse Stomach Tissue by Angelique Cheryl, Aoife Mac Cooey

Subjects: “…p53…”
Get full text

Mina53 catalyzes arginine demethylation of p53 to promote tumor growth by Lixiao Zhou, Liyang Yu, Shushu Song, Yong Wang, Qiang Zhu, Meng Li, Yutong Sha, Liang Xu, Xin Shu, Qingqing Liao, Ting Wu, Bing Yang, Siyuan Chai, Bingyi Lin, Liming Wu, Ruhong Zhou, Xiaotao Duan, Chenggang Zhu, Yuanyuan Ruan, Wen Yi

“…Mina53 catalyzes the removal of asymmetric dimethylation at arginine 337 of p53. Mina53-mediated demethylation reduces p53 stability and oligomerization and alters chromatin modifications at the gene promoter, thereby suppressing p53-mediated transcriptional activation and cell-cycle arrest. …”
Get full text

The Impact of p53 and Ki67 Expression in Endometrial Cancer and its Effect on Survival by Zekiye Sahin, Burak Bayraktar, Tugba Karadeniz, Muzaffer Sanci

Subjects: “…Endometrium cancer, Ki67, p53, Prognosis, Survival time…”
Get full text

甲状腺癌组织中H-ras 和p53 基因突变 by 李晓曦　陈国锐　赵国华　赵国强

Subjects: Get full text

Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma by Taewoo Yang, Yegyun Choi, Jae Won Joh, Steve K. Cho, Dae-Shick Kim, Sung-Gyoo Park

“…To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. …”
Get full text

肝细胞癌患者中p53 基因的突变研究 by 彭晓谋　彭文伟　周元平

Subjects: Get full text

Gallbladder Carcinomas: An Immunoprognostic Evaluation of P53; Bcl-2; CEA and Alpha-Fetoprotein by R Kanthan, JM Radhi, SC Kanthan

“…The p53 gene is the most frequently mutated gene in many human cancers, including those of the colon, breast, lung, esophagus, liver and brain. …”
Get full text

CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53 by Hongqiang Gao, Ran Xie, Rong Huang, Chonglin Wang, Yue Wang, Dongdong Wang, Kaimin Liu, Conghui Yang, Qingxiong Yang, Long Chen

“…RIP results showed that CIRBP antibody significantly enriched p53 RNA, indicating that it could directly bind to p53. …”
Get full text

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

Subjects: Get full text