P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma by Sarah Bouri, Philippe Simon, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…We report here the first case of mucinous ovarian tumor in which mutation of the PIK3CA and P53 genes could be demonstrated by the next generation sequencing technique without KRAS mutation or HER2 amplification. …”
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Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells by Razmik Mirzayans, Bonnie Andrais, Gavin Hansen, David Murray

“…These observations are made with cells that express wild-type p53, a key mediator of the DNA damage response. …”
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Prion meeting 2023: implications of a growing field by Tiago F. Outeiro, Tuane C. R. G. Vieira

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Identification of cardiac premature senescence markers through GEO database interaction approach by Tiwuk Susantiningsih, Ani Retno Prijanti, Novi Silvia Hardiany, Fadilah

Subjects: “…p53…”
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Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry by Manuel David Peris-Díaz, Artur Krężel, Perdita Barran

“…Abstract The transcription factor p53 is exquisitely sensitive and selective to a broad variety of cellular environments. …”
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T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1α/p53/p21 pathway by Yating Wang, Xu Wang, Qinghua Wu

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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Mechanistically, the administration of Clo induced the interaction of P53 with STING, which activated the non-canonical STING-NFκB pathway; consequently, NF-κB directly bound to the promoter regions of its target genes, including CCL5, CXCL10, HLAs and BAX. …”
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TP53 Mutation Predicts Worse Survival and Earlier Local Progression in Patients with Hepatocellular Carcinoma Treated with Transarterial Embolization by Ken Zhao, Anita Karimi, Luke Kelly, Elena Petre, Brett Marinelli, Erica S. Alexander, Vlasios S. Sotirchos, Joseph P. Erinjeri, Anne Covey, Constantinos T. Sofocleous, James J. Harding, William Jarnagin, Carlie Sigel, Efsevia Vakiani, Etay Ziv, Hooman Yarmohammadi

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A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer by Bohao Zhang, Haozhe Zhang, Yanru Qin

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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma by Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria

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Luteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation by Xiyan Dai, Bo Liang, Yaolin Sun

“…Moreover, troponin T, creatine kinase-myocardial band (CK-MB), inflammatory profile (IL-6, IL-1β, TNF-α), transforming growth factor-β1 (TGF-β1), oxidative stress, and matrix metalloproteinase-9 (MMP-9) were analyzed to determine the cardiac state. Cardiac NR4A2 and p53, as well as apoptotic (B-cell leukemia/lymphoma 2 [BCL-2], Caspase [CASP]-3, and CASP-9) and autophagic mediators (Sequestosome-1/p62, Microtubule-associated protein 1 A/1B-light chain 3 [LC3], and Beclin-1) were measured by RT-qPCR and ELISA. …”
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Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway by Chen Zhang, Zheming Li, Jie Wang, Xuelu Jiang, Mengting Xia, Jianfen Wang, Shenyi Lu, Shouye Li, Hanmei Wang

“…Moreover, DCFH-DA and western blot assays demonstrated that SLT enhanced ROS accumulation and subsequently activated the p53 signaling pathway. However, SLT-regulated ovarian cancer cell proliferation, apoptosis, migration, invasion, and EMT were significantly reversed by an ROS inhibitor (NAC, N-acetyl-L-cysteine). …”
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Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for therapeutic potential by Jiyauddin Khan, Priyanjana Ghosh, Urmi Bajpai, Kountay Dwivedi, Daman Saluja

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Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in different cell lines by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Abstract This study aimed to investigate the anticancer efficacy and underlying mechanism of novel platinum nanoclusters (Pt NCs) in osteosarcoma cell lines exhibiting distinct P53 expression profiles, namely MG-63 (P53−) and U2-OS (P53+). …”
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Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…At the protein level, myricitrin upregulated p53 and PUMA expression. The toxic effects of myricitrin were alleviated by the p38 inhibitor SB203580, the intracellular calcium chelator BAPTA-AM, and the NMDA receptor blocker MK-801, highlighting the significant role of the ROS/p53/p38 axis in cell death and the critical involvement of calcium ions in apoptosis induction. …”
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Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis by Adio J. Akamo, Adetutu O. Ojelabi, Oluwatobi T. Somade, Iyabode A. Kehinde, Adewale M. Taiwo, Boluwatife A. Olagunju, Mushafau A. Akinsanya, Adedayo A. Adebisi, Tobi S. Adekunbi, Abiola F. Adenowo, Florence Anifowose, Olufemi M. Ajagun-Ogunleye, Ofem E. Eteng, Jacob K. Akintunde, Regina N. Ugbaja

“…Conclusion: HESP chemotherapeutic interventions enhanced cerebral functions in DDVP-treated rats by abrogating oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspases-3 signaling.…”
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Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway by Jian-Hong Lin, Pei-Ching Ting, Wen-Sen Lee, Hung-Wen Chiu, Chun-An Chien, Chin-Hung Liu, Li-Yi Sun, Kun-Ta Yang

“…Moreover, the half-life of p53 protein was prolonged in the PAME-treated hBM-MSCs. …”
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Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

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Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development by Haijun Zhang, Lin Zhang, Ziqi Wu

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Biomarker panel for early detection of uterine cancer by Nemali Deepthi Deepthi Priya, NANDA KUMAR K V, DEVARAJAPPAGARI BINDU, KASIREDDY LIKHITHA, MEKALA SIVA CHARANI

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