p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation by Ines Höfig, Yashodhara Ingawale, Michael J. Atkinson, Heidi Hertlein, Peter J. Nelson, Michael Rosemann

“…Tri-potent bone marrow-derived MSCs from p53 wildtype and p53−/− mice were cultured under either 21% or 2% O2. …”
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PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner by Ren Zhang, Weilin Liao, Xi Chen, Junyi Wang, Jiaqi Li, Geer Chen, Weiyu Wu, Xiaoxuan Wang, Yao Zhang, Ziyu Chen, Xiaoyu Zhu, Zicong Lin, Yizhun Zhu, Lijuan Ma, Haijie Yu

“…Furthermore, our study revealed that PKCα regulates PD-L1 expression and PD-L1 sEVs secretion by influencing STAT1 phosphorylation and nuclear translocation in a p53-dependent manner. Notably, p53 can regulate STAT1 phosphorylation and nuclear localization, but it does not affect PKCα expression. …”
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Aneuploidy Mechanisms in Human Colorectal Preneoplastic Lesions and Barrett’s Esophagus. Is There a Role for K-Ras and p53 Mutations? by Walter Giaretti

“…., of the tumour suppressor gene p53 in chronic ulcerative colitis and in Barrett’s esophagus, and of the protooncogene K‐ras in colorectal adenomas. …”
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Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition by Dian Pribadi Perkasa, Iin Kurnia, Taufik Muhammad Fakih, Teja Kisnanto, Dwi Ramadhani, Harry Nugroho Eko Surniyantoro, Boky Jeanne Tuasikal, Alfian Mahardika Forentin, Mukh Syaifudin

“…In this study, in silico docking simulations were conducted to systematically assess the ability of key phytochemicals from Sitahe to modulate p53 activity, a critical gene in DNA repair and cancer therapy. …”
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Retraction Note: Effect of Oroxylum indicum on hepatocellular carcinoma via the P53 and VEGF pathways based on microfluidic chips by Xi Luo, Miao Zhao, Sicong Liu, Yi Zheng, Qiang Zhang, Yong‑rui Bao, Shuai Wang, Tian‑jiao Li, Xian‑sheng Meng

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p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. by Karen S Kelly-Spratt, Kay E Gurley, Yutaka Yasui, Christopher J Kemp

“…Ectopic expression of oncogenes such as Ras induces expression of p19(Arf), which, in turn, activates p53 and growth arrest. Here, we used a multistage model of squamous cell carcinoma development to investigate the functional interactions between Ras, p19(Arf), and p53 during tumor progression in the mouse. …”
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The Oxidative Stress Response Gene P66SHC and the Tumor Suppressor Gene P53 Induce Mitochondrial Dna Damages by Mirella Trinei, Marco Giorgio, Sara Barozzi, Pier Giuseppe Pelicci

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Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53 by Yidan Wang, Todd G. Kroll, Linhui Hao, Zhi Wen

“…Here, we demonstrate that the full-length protein isoform of NR2E3 instead of its short isoform activates wild-type p53 and is capable of rescuing certain p53 mutations in various cancer cell lines. …”
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PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

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Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity by Naoya Harada, Ichiro Nobuhara, Noriko Haruta, Yumi Higashiura, Hideki Watanabe, Sumire Ohno

“…These tumors may have become malignant due to the presence of p53 mutations.…”
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BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway by Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

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Programmed Cell Death, Proliferating Cell Nuclear Antigen and p53 Expression in Mouse Colon Mucosa during Diet-Induced Tumorigenesis by Mauro Risio, Ivana Sarotto, Francesco Paolo Rossini, Harold Newmark, Kan Yang, Martin Lipkin

“…In order to evaluate the roles both of cell proliferation and programmed cell death (PCD) in WD‐induced tumorigenesis, immunohistochemical detection of proliferating nuclear antigen (PCNA), in situ end labeling (TUNEL) of DNA breaks, and p53 protein were carried out in mouse colonic mucosa during prolonged feeding of two WDs. …”
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Mutated p53 Promotes the Symmetric Self-Renewal of Cisplatin-Resistant Lung Cancer Stem-Like Cells and Inhibits the Recruitment of Macrophages by Yu Xu, Zhi Xu, Qi Li, Liang Guo, Yao Wang, Jianchun Zhou, Guansong Wang, Yuliang Liu

“…It has been proposed that mutant p53 is correlated with the recurrence of lung cancer. …”
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Korelasi antara Latent Membrane Protein-1 Virus Epstein-Barr dengan P53 pada Karsinoma Nasofaring (Penelitian Lanjutan) by Yenita ., Aswiyanti Asri

“…Kesimpulan: Terdapat korelasi yang lemah antara ekspresi LMP-1 dengan ekspresi p53 pada KNF. Kata kunci: LMP-1, Virus Epstein-Barr, p53, Karsinoma nasofaring.. …”
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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

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Key Roles of p53 Signaling Pathway-Related Factors GADD45B and SERPINE1 in the Occurrence and Development of Gastric Cancer by Yaoqing Li, Liyijing Shen, Kelong Tao, Guangen Xu, Kewei Ji

“…p53 can function as an independent and unfavorable prognosis biomarker in cancer patients. …”
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Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new ent... by Zeliha Çelik, Naile Kökbudak, Fahriye Kilinç, Pembe Oltulu

Subjects: “…p53…”
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Ginger polysaccharide UGP1 suppressed human colon cancer growth via p53, Bax/Bcl-2, caspase-3 pathways and immunomodulation by Yanfang Qian, Chenying Shi, Chen Cheng, Dengwei Liao, Junping Liu, Gui-tang Chen

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