Western 印迹杂交分析 p53 蛋白在人鼻咽癌中的表达 by 郑美莲　区宝祥　龙江斌　邓满泉　陈丽珍　梁启万　李辉梅

“…目的: 探讨 p53 蛋白在人鼻咽癌中的表达及其临床意义。方法: 采用 Western 印迹法结合免疫沉淀技术, 检测鼻 咽活检组织 p53 蛋白表达。…”
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Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

“…The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. …”
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p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation by Na Li, Zhaoyu Du, Yunxiang Li, Wenjing Xu, Yumei Yang, Haodong Peng, Tianxiang Song, Qihua Qin, Huining Lei, Jinlian Hua

“…Further analysis showed that p57 could interact with and contribute to the activation of p53 in mESCs. In conclusion, the present study showed that p57 could antagonize the pluripotency state and the proliferation process of mESCs. …”
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重组野生型 p53 基因转染人骨肉瘤细胞株体外实验

“…目的: 将外源性野生型 p53 基因导入人骨肉瘤细胞株, 研究野生型 p53 蛋白在诱导瘤细胞凋亡中的作用。方法: 用 DNA 转染技术将 7 重组野生型 p53 基因 PM 47质粒导入人骨肉瘤细胞株 HOS-8603中, 用 PCR 技术监测外源性 p53 基因 在瘤细胞中存在的稳定性; 用免疫组化方法检测在地塞米松的诱导下瘤细胞中 p53 的表达情况; 用相差显微镜去观察凋亡瘤 细胞的形态特点; 用细胞凋亡原位检测技术标记并统计凋亡的瘤细胞数。…”
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PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck by Karin Nylander, Elsy‐Britt Schildt, Mikael Eriksson, Göran Roos

“…Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow‐up of 4–14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki‐67, p53, bcl‐2 and presence of mutations in the p53 gene. …”
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Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…We identified TP53 status as a critical determinant of transcriptional response to both RT and TMZ, which was also modulated by the differentiation state and treatment modality in wildtype (wt) p53 GBM cells. Both mutant and wt p53 models exhibited significant activation of the DNA-damage associated interferon (IFN) response in CSCs and differentiated cells, implicating this pathway in the GBM response to therapy. …”
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p53 蛋白及 c-erbB-2 蛋白在胆囊癌中的表达

Subjects: “…蛋白质 p53/生物合成/原癌基因蛋白质/c-erbB-2 类/生物合成…”
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Molecular Mechanisms of Synergistic Effect of PRIMA‐1met and Oxaliplatin in Colorectal Cancer With Different p53 Status by Xiao‐lan Li, Jianbiao Zhou, Nicole Xin‐Ning Tang, Yi Chai, Meng Zhou, Ai‐di Gao, Zhong‐kai Lu, Han Min

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p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment by Darya Yanushko, Beatriz German Falcon, Rana El Bizri, Despoina Pervizou, Robin Dolgos, Céline Keime, Tao Ye, Christelle Thibault-Carpentier, Clementine Le Magnen, Sandrine Henri, Gilles Laverny, Daniel Metzger

“…Thus, our study demonstrates that p53 loss induces a protumorigenic crosstalk between PECs and CAFs, and identifies new vulnerabilities that might be targeted to limit cancer progression.…”
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High Expression of UPK3A Promotes the Progression of Gastric Cancer Cells by Inactivating p53 Pathway by Deliang Xu, Jing Guo, Hongwei Xu

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that UPK3A was involved in the p53 signaling pathway. UPK3A suppressed the activation of p53 signaling pathway, and treatment with Pifithrin-α (an inhibitor of the p53 signaling pathway) or silencing of p53 significantly reversed the effect of UPK3A silencing on the expression of p53, KLF4, ZMAT3, MDM2, and SP1. …”
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Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma by Elena N. Voropaeva, Yuriy L. Orlov, Anastasia B. Loginova, Olga B. Seregina, Vladimir N. Maksimov, Tatiana I. Pospelova

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Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma by Odessa R Yabut, Jessica Arela, Hector G Gomez, Jesse Garcia Castillo, Thomas Ngo, Samuel J Pleasure

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Study of morphology with assessment of expression of proliferation marker Ki67 antigen and P53 protein in lesions of gall bladder by Ojasvi Ramesh, Mamta Gupta, Sanjay Kaushik, Seema Acharya, Brijesh Thakur, Aparna Bhardwaj

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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur by Xue Zheng, Yuhua Luo, Rui Huo, Yiwen Wang, Youbang Chen, Mianrong Chen, Qi Zhao, Kexin Li, Hanyi Zhang, Xiaotong Li, Xiang Li, Hui Zhang, Zaopeng He, Li Huang, Chun-tao Yang

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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment by Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest

“…In the absence of p53, the early expansion of murine gammaherpesvirus 68 latency greatly increases, especially in germinal center B cells, a cell type whose proliferation is conversely restricted by p53. …”
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SV40 Tag/p53 Complexes Actively Promote Malignant Cell Growth of Human Mesothelial Cells [1] by Maurizio Bocchetta, Michele Carbone

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RETRACTED ARTICLE: Effect of Oroxylum indicum on hepatocellular carcinoma via the P53 and VEGF pathways based on microfluidic chips by Xi Luo, Miao Zhao, Sicong Liu, Yi Zheng, Qiang Zhang, Yong-rui Bao, Shuai Wang, Tian-jiao Li, Xian-sheng Meng

“…Results The results showed that OI upregulated the expression of Bax, P53 and Caspase-3 and downregulated the expression of Bcl-2 and MDM2. …”
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p53 dosage can impede KrasG12D- and KrasQ61R-mediated tumorigenesis. by Özgün Le Roux, Jeffery I Everitt, Christopher M Counter

“…Conversley, an extra copy of Trp53 (Super p53) was recently shown to suppress Kras-induced tumorigenesis in a genetic model of this disease. …”
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p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation by Ines Höfig, Yashodhara Ingawale, Michael J. Atkinson, Heidi Hertlein, Peter J. Nelson, Michael Rosemann

“…Tri-potent bone marrow-derived MSCs from p53 wildtype and p53−/− mice were cultured under either 21% or 2% O2. …”
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