The Effect of FOXA3 Overexpression on Hepatocyte Differentiation and Liver Regeneration in a Fah cKO Mouse ModelSummary by Shao Li, Chupeng Ou, Jiajun Zhang, Min Zeng, Kangyan Liang, Qing Peng, Yi Gao

“…However, the expression of cell cycle–related proteins, including p53 and p21, was decreased in vivo. Injection of an HNF4α antagonist revealed that inhibition of HNF4α effectively suppressed the regenerative capacity of the liver after RF3 spheroid transplantation, resulting in an increase in the number of p53- and p21-positive cells and a decrease in the expression levels of liver function–related genes. …”
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Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature by Vishwas Parekh, Thomas Winokur, Robert J. Cerfolio, Todd M. Stevens

“…The lesional cells expressed cytokeratin, calretinin, and nuclear WT1 but were negative for PAX8, TTF1, p53, chromogranin, CD31, and CD34, and Ki67 showed <2% proliferation rate, diagnostic of adenomatoid tumor. …”
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Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63 by Kathryn E. King, Linan Ha, Tura Camilli, Wendy C. Weinberg

“…Mouse models have informed us that p63 is critical for normal epidermal development and homeostasis. The p53/p63/p73 family is expressed as multiple protein isoforms due to a combination of alternative promoter usage and C-terminal alternative splicing. …”
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The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

“…We transfected Box A plasmid into lung cancer cell lines to overexpress Box A and evaluated the expression levels of γH2AX foci and other DNA damage response (DDR) signaling cascade markers, including ATM, ATR, and p53. Then, we demonstrated the downstream effects of DSBs on lung cancer, lowering cell proliferation, decreasing cell migration, and promoting apoptosis. …”
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Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation by Noor Marji, Jasrerman Dhillon, Gregory Y. Lauwers, Sebastian Feuerlein, Reza Nikfar, Monica Chatwal, Aram Vosoughi

“…Molecular studies identified BRAF V600E, SMAD4, and p53 mutations associated with aggressive colorectal adenocarcinoma with mucinous/signet ring cell features. …”
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ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells. by Xiaohui He, Yadong Sun, Hanhui Ma

“…A pair of genomic loci labeled by ParSite could be colocalized with p53-binding protein 1 (53BP1) in response to CRISPR/Cas9-mediated double-strand breaks (DSBs). …”
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The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients by Rehab M. Samaka, Hayam A. Aiad, Mona A. Kandil, Nancy Y. Asaad, Nanes S. Holah

“…SV40 induces malignant transformation by the large T-antigen (L-TAG) and promotes transformation by binding and inactivating p53 and pRb. L-TAG can bind pRb promoting the activation of the E2F1 transcription factor, thus inducing the expression of genes required for the entry to the S phase and leading to cell transformation. …”
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Medullary breast carcinoma: a pathogenic review and immunohistochemical study using tissue microarray by Ming Lee, Ana Richelia Jara-Lazaro, Poh Yian Cheok, Aye Aye Thike

“…Methods: This study aimed to review the clinicopathological features of MBCs diagnosed at the Department of Pathology, Singapore General Hospital and correlate them with immunohistochemical expression of hormonal markers and c-erbB-2, the basal markers p53, cytokeratin (CK) 14, epidermal growth factor receptor (EGFR) and 34BE12, and the follow-up outcome. …”
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Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B1-Induced Experimental Hepatocellular Carcinoma by Vijaya Ravinayagam, Ravindran Jaganathan, Sachdanandam Panchanadham, Shanthi Palanivelu

“…Significant exposure to Aflatoxin B1 (AFB1), a potent hepatotoxic and hepatocarcinogenic mycotoxin, plays a major role in liver carcinogenesis through oxidative tissue damage and p53 mutation. The present study emphasizes the anticarcinogenic effect of Tridham (TD), a polyherbal traditional medicine, on AFB1-induced HCC in male Wistar rats. …”
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(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Me... by Chella Perumal Palanisamy, Bo Cui, Hongxia Zhang, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan

“…The protein that is responsible for the death of cells (Bcl-2 and Bcl-xL) was reduced (p<0.05), while the protein expression of p53 and caspase-9 was increased (p<0.05) in compound 2-treated HO-8910 cells. …”
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The influence of follicular fluid on the regulation of apoptosis and related genes during IVM of camel oocytes by A.A. Ammari, AR. Alhimaidi, K.N. Yaseen, B.O. Almutairi, R.A. Amran, A. AL-juaimlan, A. Rady

“…Hypothetically, IVM medium was enhanced with 2.5% CFF, and we analyzed the expression of several genes including Bax, Bcl-2, P53, Acta2, TGFβ, Cx43, and Tagln. Consequently, the follicular fluid from camels had a substantial effect on the mRNA transcript level of the BCL2 gene, which is related to apoptosis. …”
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Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…In recent years, research on the MSI protein has advanced, and many novel viewpoints and drug resistance attempts have been derived; for example, tumor protein p53 mutations and MSI-binding proteins lead to resistance to protein arginine N-methyltransferase 5-targeted therapy in lymphoma patients. …”
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Neuroprotective effects of gastrodin in both in vivo and in vitro models of Parkinson's disease: Mechanisms from the perspective of oxidative stress, ferroptosis, and cellular sene... by Shanshan Li, Meng Wang, Buyun Jia, Baikun Li, Hui Cheng, Shasha Tian, Qinglin Li

“…The results of molecular docking and immunofluorescence showed that p53 may be an important target of GAS. After treatment with Pifithrin-α, the protective effect of GAS was enhanced. …”
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Image Analysis Based Grading of Bladder Carcinoma. Comparison of Object, Texture and Graph Based Methods and Their Reproducibility by Heung‐Kook Choi, Torsten Jarkrans, Ewert Bengtsson, Janos Vasko, Kenneth Wester, Per-Uno Malmström, Christer Busch

“…In addition, image analysis based grading showed almost identical correlation to mitotic density and expression of p53 protein as subjective grading. It should thus be possible to use this kind of image analysis as a prognostic tool for bladder carcinoma.…”
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Expression Pattern of a Homeotic Gene, HOXA5, in Normal Breast and in Breast Tumors by Gregory S. Henderson, Paul J. van Diest, Horst Burger, Jose Russo, Venu Raman

“…Recent evidence has indicated that HOXA5 regulates both p53 and progesterone receptor expression levels in breast cancer cells. …”
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Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Both ADSCs and the ADSC-secretome improved the IR-induced ultrastructural changes in hepatocytes and significantly decreased the proportion of TUNEL-positive apoptotic cells along with caspase activity. Consistent with this, P53, Bax, Fas, and Fasl mRNA and protein levels were markedly decreased, while Bcl-2 was significantly increased in the animals treated with ADSCs and ADSC-secretome. …”
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PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress by Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

“…These DEGs were significantly enriched in critical aging pathways, including the p53 signaling pathway, autophagy, and cellular senescence. …”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…Also other important signaling proteins, like NF-κB, p53, and retinoblastoma protein (RB), showed important activity modifications. …”
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Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury by Jipeng Ouyang, Rong Li, Haiqin Shi, Jianping Zhong

“…In addition, several cell death-related genes (p53, p21, Bax, and Bcl-2) were detected by PCR, and an apoptosis-related protein (caspase3) was evaluated by western blotting. …”
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Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine by Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zhou

“…In addition, berberine was found to interact with a mixture of biological pathways, such as Alzheimer’s disease-presenilin and -secretase pathways, angiogenesis, apoptosis signalling pathway, FAS signalling pathway, Hungtington disease, inflammation mediated by chemokine and cytokine signalling pathways, interleukin signalling pathway, and p53 pathways. We also explored the possible mechanism of action for the anti-diabetic effect of berberine. …”
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